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Journal of Materials Science
Erschienen in: Journal of Materials Science 6/2017

18.11.2016 | Original Paper

Polysaccharides/mesoporous silica nanoparticles hybrid composite hydrogel beads for sustained drug delivery

verfasst von: Yan Hu, Xiaoying Dong, Lei Ke, Shangwen Zhang, Dan Zhao, Han Chen, Xincai Xiao

Erschienen in: Journal of Materials Science | Ausgabe 6/2017

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Abstract

A simple and effective route was established to regulate the drug release kinetics of hydrogels through a combination method of the polysaccharides matrix which delivers the drug and the mesoporous silica nanoparticles (MSN) as a reservoir, making the system release the payload in a controlled manner. The composite MSN beads can construct one kind of novel sustained drug administration device maintaining 24 h activity. With the increase of the MSN ratio in the beads, the sustained-release profile can be increased. The drug release kinetics provide clear evidence that the composite MSN beads delivery systems can protect the model drug of bovine serum albumin from external denaturants and release them slowly in a predictable model. These composite MSN beads with higher drug-loading capacity and better retention ability may facilitate sustained/controlled drug delivery systems for pharmaceutical and biomedical applications.
Vorheriger Artikel Ultraviolet to far-infrared transmission properties of thin film multi-walled carbon nanotube random networks
Nächster Artikel Controlled hydrothermal synthesis and luminescent properties of Y2WO6:Eu3+ nanophosphors for light-emitting diodes

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Metadaten
Titel
Polysaccharides/mesoporous silica nanoparticles hybrid composite hydrogel beads for sustained drug delivery
verfasst von
Yan Hu
Xiaoying Dong
Lei Ke
Shangwen Zhang
Dan Zhao
Han Chen
Xincai Xiao
Publikationsdatum
18.11.2016
Verlag
Springer US
Erschienen in
Journal of Materials Science / Ausgabe 6/2017
Print ISSN: 0022-2461
Elektronische ISSN: 1573-4803
DOI
https://doi.org/10.1007/s10853-016-0597-x

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