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Journal of Polymer Research
Erschienen in: Journal of Polymer Research 6/2011

01.11.2011 | Original Paper

Synthesis and characterisation of thermo-sensitive terpolymer hydrogels for drug delivery applications

verfasst von: Jude I. Ngadaonye, Martin O. Cloonan, Luke M. Geever, Clement L. Higginbotham

Erschienen in: Journal of Polymer Research | Ausgabe 6/2011

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Abstract

In this study, thermo-sensitive terpolymer hydrogels based on N-tert-butylacrylamide (NtBAAm), N-isopropylacrylamide (NIPAAm) and N-vinyl pyrrolidone (NVP) were successfully photopolymerised and characterised. 1-hydroxy-cyclohexylphenylketone (Irgacure 184) and 2-hydroxy-2-methyl-1-phenyl-propanone (Irgacure 2959) were used as light-sensitive initiators to initiate the reactions. Chemical structures of the hydrogels were confirmed using Fourier transform infrared (FTIR) and nuclear magnetic resonance (NMR) spectroscopy. The hydrogels were also characterised using modulated differential scanning calorimetry (MDSC) for their glass transition and phase transition temperatures. A single glass transition temperature (T g ) was observed, further confirming successful formation of a terpolymer. The hydrogels were thermo-responsive, exhibiting a decrease in lower critical solution temperature (LCST) as the NtBAAm weight ratio was increased. Pulsatile swelling studies indicated that the hydrogels had thermo-reversible properties and the swelling properties were dependent on test temperature, monomer feed ratios and crosslinker content. The proposed hydrogel system could find applications in a broader field of gel/drug interaction, for the development of controlled release and targeted delivery devices.
Vorheriger Artikel RFL coated aramid short fiber reinforced thermoplastic elastomer: Mechanical, rheological and morphological characteristics
Nächster Artikel Synthesis and properties of thermoreversible crosslinking supramolecular polymer with weak multiple-hydrogen bonds and small chemical network sites from dimer acid, diamine and sulfonyl isocyanate

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Metadaten
Titel
Synthesis and characterisation of thermo-sensitive terpolymer hydrogels for drug delivery applications
verfasst von
Jude I. Ngadaonye
Martin O. Cloonan
Luke M. Geever
Clement L. Higginbotham
Publikationsdatum
01.11.2011
Verlag
Springer Netherlands
Erschienen in
Journal of Polymer Research / Ausgabe 6/2011
Print ISSN: 1022-9760
Elektronische ISSN: 1572-8935
DOI
https://doi.org/10.1007/s10965-011-9644-0

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