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Journal of Nanoparticle Research

Erschienen in:

01.02.2010 | Research Paper

Antibacterial effect of composite resins containing quaternary ammonium polyethyleneimine nanoparticles

verfasst von: Ira Yudovin-Farber, Nurit Beyth, Ervin I. Weiss, Abraham J. Domb

Erschienen in: Journal of Nanoparticle Research | Ausgabe 2/2010

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Abstract

Quaternary ammonium polyethyleneimine (QA-PEI)-based nanoparticles were synthesized by crosslinking with dibromopentane followed by N-alkylation with various alkyl halides and further N-methylation with methyl iodide. Insoluble pyridinium-type particles were prepared by suspension polymerization of 4-vinyl pyridine followed by N-alkylation with alkyl halides. Polyamine-based nanoparticles embedded in restorative composite resin at 1% w/w were tested for antibacterial activity against Streptococcus mutans using direct contact test. Activity analysis revealed that the alkyl chain length of the QA-PEI nanoparticles plays a significant role in antibacterial activity of the reagent. The most potent compound was octyl-alkylated QA-PEI embedded in restorative composite resin at 1% w/w that totally inhibited S. mutans growth in 3-month-aged samples. This data indicates that restorative composite resin with antibacterial properties can be produced by the incorporation of QA-PEI nanoparticles.

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Titel: Antibacterial effect of composite resins containing quaternary ammonium polyethyleneimine nanoparticles
verfasst von: Ira Yudovin-Farber
Nurit Beyth
Ervin I. Weiss
Abraham J. Domb
Publikationsdatum: 01.02.2010
Verlag: Springer Netherlands
Erschienen in: Journal of Nanoparticle Research / Ausgabe 2/2010
Print ISSN: 1388-0764
Elektronische ISSN: 1572-896X
DOI: https://doi.org/10.1007/s11051-009-9628-8

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