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Journal of Nanoparticle Research

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01.06.2013 | Research Paper

DPPC/poly(2-methyl-2-oxazoline)-grad-poly(2-phenyl-2-oxazoline) chimeric nanostructures as potential drug nanocarriers

verfasst von: Natassa Pippa, Eleni Kaditi, Stergios Pispas, Costas Demetzos

Erschienen in: Journal of Nanoparticle Research | Ausgabe 6/2013

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Abstract

In this study, we report on the self assembly behavior and on stability studies of mixed (chimeric) nanosystems consisting of dipalmitoylphosphatidylcholine (DPPC) and poly(2-methyl-2-oxazoline)-grad-poly(2-phenyl-2-oxazoline) (MPOx) gradient copolymer in aqueous media and in fetal bovine serum (FBS). A gamut of light scattering techniques and fluorescence spectroscopy were used in order to extract information on the size and morphological characteristics of the nanoassemblies formed, as a function of gradient block copolymer content, as well as temperature. The hydrodynamic radii (R _h) of nanoassemblies decreased in the process of heating up to 50 °C, while the fractal dimension (d _f) values, also increased. Indomethacin was successfully incorporated into these chimeric nanocarriers. Drug release was depended on the components ratio. The present studies show that there are a number of parameters that can be used in order to alter the properties of chimeric nanosystems, and this is advantageous to the development of “smart” nanocarriers for drug delivery.

Vorheriger Artikel Agglomeration and sedimentation of titanium dioxide nanoparticles (n-TiO2) in synthetic and real waters

Nächster Artikel Effects of alcohol solvents on anatase TiO2 nanocrystals prepared by microwave-assisted solvothermal method

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Titel: DPPC/poly(2-methyl-2-oxazoline)-grad-poly(2-phenyl-2-oxazoline) chimeric nanostructures as potential drug nanocarriers
verfasst von: Natassa Pippa
Eleni Kaditi
Stergios Pispas
Costas Demetzos
Publikationsdatum: 01.06.2013
Verlag: Springer Netherlands
Erschienen in: Journal of Nanoparticle Research / Ausgabe 6/2013
Print ISSN: 1388-0764
Elektronische ISSN: 1572-896X
DOI: https://doi.org/10.1007/s11051-013-1685-3

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