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Journal of Nanoparticle Research

Erschienen in:

01.09.2018 | Research Paper

Hyaluronic acid-coated liposome for active targeting on CD44 expressing tumors

verfasst von: Zhenfen Tian, Jianwen Liu, Na Li, Vasil M. Garamus, Aihua Zou

Erschienen in: Journal of Nanoparticle Research | Ausgabe 9/2018

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Abstract

Liposome coated with hyaluronic acid (HA) was fabricated for targeted delivery of Doxorubicin hydrochloride (DOX) to CD44 expressing tumors. DOX was incorporated into liposome (DOX-L) via a transmembrane pH-gradient method, which contributed to high encapsulation efficiency (97%) and drug loading (19%). HA was modified on the surface of DOX-L by simple vortex (HA-DOX-L). The average diameter of optimized DOX-L and H-DOX-L was 109.7 ± 3.1 and 117.2 ± 5.0 nm, respectively, with good uniformity and stability during 6-month storage. SAXS and TEM evidenced the corona of HA on the surface of DOX-L, which convinced the prolonged circulation of DOX. The apoptosis study demonstrated the improved efficacy of HA-DOX-L with the human colon cancer cell line HCT-116 cells in comparison to the conventional reservoirs. This improved efficacy of HA-DOX-L with HCT-116 cells should be related with the interaction between HA and CD44 receptor of HCT-116 cells.

Vorheriger Artikel Solvothermal synthesis of hydrophobic carbon dots in reversed micelles

Nächster Artikel Behavior of hybrid thermosensitive nanosystem dextran-graft-PNIPAM/gold nanoparticles: characterization within LCTS

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Titel: Hyaluronic acid-coated liposome for active targeting on CD44 expressing tumors
verfasst von: Zhenfen Tian
Jianwen Liu
Na Li
Vasil M. Garamus
Aihua Zou
Publikationsdatum: 01.09.2018
Verlag: Springer Netherlands
Erschienen in: Journal of Nanoparticle Research / Ausgabe 9/2018
Print ISSN: 1388-0764
Elektronische ISSN: 1572-896X
DOI: https://doi.org/10.1007/s11051-018-4324-1

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