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Erschienen in: Quality of Life Research 4/2018

22.01.2018

Longitudinal study of quality of life among children with acute respiratory infection and cough

verfasst von: Yolanda G. Lovie-Toon, Anne B. Chang, Peter A. Newcombe, Dimitrios Vagenas, Sophie Anderson-James, Benjamin J. Drescher, Michael E. Otim, Kerry-Ann F. O’Grady

Erschienen in: Quality of Life Research | Ausgabe 4/2018

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Abstract

Purpose

Acute respiratory infections (ARIs), and associated symptoms such as cough, are frequently experienced among children and impose a burden on families (e.g., use of medical resources and time off work/school). However, there are little data on changes in, and predictors of, quality of life (QoL) over the duration of an ARI with cough (ARIwC) episode. We therefore aimed to determine cough-specific QoL and identify its influencing factors among children with ARIwC, at the time of presentation to a pediatric emergency department (ED), and over the following 4 weeks.

Methods

Data from 283 children aged < 15 years were included in our analyses. We used the validated parent-proxy children’s acute cough-specific QoL questionnaire (PAC-QoL) at each time-point. Linear regression and mixed effect modeling were used to identify factors influencing QoL at baseline and over the follow-up period.

Results

Median PAC-QoL at baseline was 2.7 (IQR 2.1–3.6) and significantly improved by Day-7 (4.9, IQR 3.8–6.1) and Day-14 (6.59, IQR 5.1–7.0), both p < 0.001. The improvements in median PAC-QoL between Days-14, -21, and -28 were not significant. Regression modeling identified that day-cough severity, night-cough severity, and financial concerns had the highest impact on both baseline, and follow-up, PAC-QoL scores. There were five additional independent significant factors at baseline and six at follow-up.

Conclusions

Quality of life is considerably impaired at presentation to ED, but improves significantly by Days-7 and -14. As cough severity and financial concerns had the highest impact on QoL, effectively managing cough to reduce the clinical and financial burden on children and families is important.

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Metadaten
Titel
Longitudinal study of quality of life among children with acute respiratory infection and cough
verfasst von
Yolanda G. Lovie-Toon
Anne B. Chang
Peter A. Newcombe
Dimitrios Vagenas
Sophie Anderson-James
Benjamin J. Drescher
Michael E. Otim
Kerry-Ann F. O’Grady
Publikationsdatum
22.01.2018
Verlag
Springer International Publishing
Erschienen in
Quality of Life Research / Ausgabe 4/2018
Print ISSN: 0962-9343
Elektronische ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-017-1779-y

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