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Erschienen in:
Computational Modelling of Wound Healing Insights to Develop New Treatments Kapitel lesen Erstes Kapitel lesen

2019 | OriginalPaper | Buchkapitel

Low Temperature 3D Printing of Drug Loaded Bioceramic Scaffolds and Implants

verfasst von : Susanne Meininger, Elke Vorndran, Miguel Castilho, Paulo Rui Fernandes, Uwe Gbureck

Erschienen in: New Developments in Tissue Engineering and Regeneration

Verlag: Springer International Publishing

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Abstract

3D powder printing (3DP) enables the fabrication of porous scaffolds with anisotropic aligned pores for bone tissue engineering and for the fabrication of custom made implants for cranio-maxillofacial surgery. By combining 3D printing and self-setting biocement matrices, a low temperature processing chain can be established for a simultaneous spatial control over both structure geometry and composition by using multi-colour printers. This contribution aims to highlight bioceramic material approaches in order to fabricate scaffolds and implants by 3DP with a special emphasis on the drug modification of such structures.

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Vorheriges Kapitel Adaptive Multi-resolution Volumetric Modeling of Bone Micro-structure
Nächstes Kapitel A Biomechanical Approach for Bone Regeneration Inside Scaffolds Embedded with BMP-2
Literatur
1.
Vorndran E, Moseke C, Gbureck U (2015) 3D printing of ceramic implants. MRS Bull 40:127–136
2.
Garrett B (2014) 3D printing: new economic paradigms and strategic shifts. Glob Policy 5:70–75CrossRef
3.
Melchels FPW, Feijen J, Grijpma DW (2010) A review on stereolithography and its applications in biomedical engineering. Biomaterials 31:6121–6130CrossRef
4.
Teo EY, Ong SY, Chong MSK, Zhang ZY, Lu J, Moochhala S et al (2011) Polycaprolactone-based fused deposition modeled mesh for delivery of antibacterial agents to infected wounds. Biomaterials 32:279–287CrossRef
5.
Butscher A, Bohner M, Doebelin N, Galea L, Loeffel O, Muller R (2013) Moisture based three-dimensional printing of calcium phosphate structures for scaffold engineering. Acta Biomater 9:5369–5378CrossRef
6.
Butscher A, Bohner M, Hofmann S, Gauckler L, Muller R (2011) Structural and material approaches to bone tissue engineering in powder-based three-dimensional printing. Acta Biomater 7:907–920CrossRef
7.
Butscher A, Bohner M, Roth C, Ernstberger A, Heuberger R, Doebelin N et al (2012) Printability of calcium phosphate powders for three-dimensional printing of tissue engineering scaffolds. Acta Biomater 8:373–385CrossRef
8.
Suwanprateeb J, Suvannapruk W, Wasoontararat K (2010) Low temperature preparation of calcium phosphate structure via phosphorization of 3D-printed calcium sulfate hemihydrate based material. J Mater Sci Mater Med 21:419–429CrossRef
9.
Gbureck U, Hozel T, Klammert U, Wurzler K, Muller FA, Barralet JE (2007) Resorbable dicalcium phosphate bone substitutes prepared by 3D powder printing. Adv Func Mater 17:3940–3945CrossRef
10.
Leukers B, Gulkan H, Irsen SH, Milz S, Tille C, Schieker M et al (2005) Hydroxyapatite scaffolds for bone tissue engineering made by 3D printing. J Mater Sci Mater Med 16:1121–1124CrossRef
11.
Luo YX, Lode A, Akkineni AR, Gelinsky M (2015) Concentrated gelatin/alginate composites for fabrication of predesigned scaffolds with a favorable cell response by 3D plotting. RSC Adv 5:43480–43488CrossRef
12.
Luo YX, Lode A, Sonntag F, Nies B, Gelinsky M (2013) Well-ordered biphasic calcium phosphate-alginate scaffolds fabricated by multi-channel 3D plotting under mild conditions. J Mater Chem B 1:4088–4098CrossRef
13.
Brown TD, Edin F, Detta N, Skelton AD, Hutmacher DW, Dalton PD (2014) Melt electrospinning of poly(epsilon-caprolactone) scaffolds: phenomenological observations associated with collection and direct writing. Mater Sci Eng C Mater Biol Appl 45:698–708CrossRef
14.
Mota C, Puppi D, Gazzarri M, Bartolo P, Chiellini F (2013) Melt electrospinning writing of three-dimensional star poly(E-caprolactone) scaffolds. Polym Int 62:893–900CrossRef
15.
Sadeghian Z, Heinrich JG, Moztaradeh F (2004) Direct laser sintering of hydroxyapatite implants by layer-wise slurry deposition (LSD). CFI-Ceramic Forum Int 81:E39–E43
16.
Ryan GE, Pandit AS, Apatsidis DP (2008) Porous titanium scaffolds fabricated using a rapid prototyping and powder metallurgy technique. Biomaterials 29:3625–3635CrossRef
17.
Hutmacher DW (2001) Scaffold design and fabrication technologies for engineering tissues—state of the art and future perspectives. J Biomater Sci Polym Ed 12:107–124CrossRef
18.
Legeros RZ, Lin S, Rohanizadeh R, Mijares D, Legeros JP (2003) Biphasic calcium phosphate bioceramics: preparation, properties and applications. J Mater Sci Mater Med 14:201–209CrossRef
19.
Bakarich SE, Gorkin R, Panhuis MIH, Spinks GM (2014) Three-dimensional printing fiber reinforced hydrogel composites. ACS Appl Mater Interfaces 6:15998–16006CrossRef
20.
Inzana JA, Olvera D, Fuller SM, Kelly JP, Graeve OA, Schwarz EM et al (2014) 3D printing of composite calcium phosphate and collagen scaffolds for bone regeneration. Biomaterials 35:4026–4034CrossRef
21.
Klammert U, Gbureck U, Vorndran E, Rodiger J, Meyer-Marcotty P, Kubler AC (2010) 3D powder printed calcium phosphate implants for reconstruction of cranial and maxillofacial defects. J Cranio Maxillofac Surg 38:565–570CrossRef
22.
Aaboe M, Pinholt EM, Hjortinghansen E (1995) Healing of experimentally created defects—a review. Br J Oral Maxillofac Surg 33:312–318CrossRef
23.
Karageorgiou V, Kaplan D (2005) Porosity of 3D biomaterial scaffolds and osteogenesis. Biomaterials 26:5474–5491CrossRef
24.
Vorndran E, Klammert U, Ewald A, Barralet JE, Gbureck U (2010) Simultaneous immobilization of bioactives during 3D powder printing of bioceramic drug-release matrices. Adv Func Mater 20:1585–1591CrossRef
25.
Lode A, Krujatz F, Bruggemeier S, Quade M, Schutz K, Knaack S et al (2015) Green bioprinting: fabrication of photosynthetic algae-laden hydrogel scaffolds for biotechnological and medical applications. Eng Life Sci 15:177–183CrossRef
26.
Vorndran E, Wunder K, Moseke C, Biermann I, Muller FA, Zorn K et al (2011) Hydraulic setting Mg3(PO4)2 powders for 3D printing technology. Adv Appl Ceram 110:476–481CrossRef
27.
Seitz H, Rieder W, Irsen S, Leukers B, Tille C (2005) Three-dimensional printing of porous ceramic scaffolds for bone tissue engineering. J Biomed Mater Res Part B Appl Biomater 74B:782–788CrossRef
28.
Leukers B, Gulkan H, Irsen SH, Milz S, Tille C, Seitz H et al (2005) Biocompatibility of ceramic scaffolds for bone replacement made by 3D printing. Materialwiss Werkstofftech 36:781–787CrossRef
29.
Gbureck U, Holzel T, Doillon CJ, Muller FA, Barralet JE (2007) Direct printing of bioceramic implants with spatially localized angiogenic factors. Adv Mater 19:795–+
30.
Gbureck U, Holzel T, Thull R, Muller FA, Barralet JE (2006) Preparation of nanocrystalline hydroxyapatite scaffolds by 3D powder printing. Cytotherapy 8:14
31.
Bergmann C, Lindner M, Zhang W, Koczur K, Kirsten A, Telle R et al (2010) 3D printing of bone substitute implants using calcium phosphate and bioactive glasses. J Eur Ceram Soc 30:2563–2567CrossRef
32.
Bose S, Vahabzadeh S, Bandyopadhyay A (2013) Bone tissue engineering using 3D printing. Mater Today 16:496–504CrossRef
33.
Hwa LC, Rajoo S, Noor AM, Ahmad N, Uday MB (2017) Recent advances in 3D printing of porous ceramics: a review. Curr Opin Solid State Mater Sci 21:323–347CrossRef
34.
Kumar A, Mandal S, Barui S, Vasireddi R, Gbureck U, Gelinsky M et al (2016) Low temperature additive manufacturing of three dimensional scaffolds for bone-tissue engineering applications: processing related challenges and property assessment. Mater Sci Eng R Rep 103:III-39
35.
Sachs EM CM, Bredt JF (1996) Process for removing loose powder particles from interior passages of a body. United States: U.S. Patent and Trademark Office. Massachusetts Institute of Technology, pp 5, 490, 882
36.
Butscher A, Bohner M, Doebelin N, Hofmann S, Muller R (2013) New depowdering-friendly designs for three-dimensional printing of calcium phosphate bone substitutes. Acta Biomater 9:9149–9158CrossRef
37.
Suwanprateeb J, Sanngam R, Suwanpreuk W (2008) Fabrication of bioactive hydroxyapatite/bis-GMA based composite via three dimensional printing. J Mater Sci Mater Med 19:2637–2645CrossRef
38.
Winkel A, Meszaros R, Reinsch S, Muller R, Travitzky N, Fey T et al (2012) Sintering of 3D-printed glass/HAp composites. J Am Ceram Soc 95:3387–3393CrossRef
39.
Castilho M, Dias M, Gbureck U, Groll J, Fernandes P, Pires I et al (2013) Fabrication of computationally designed scaffolds by low temperature 3D printing. Biofabrication 5
40.
Meininger S, Mandal S, Kumar A, Groll J, Basu B, Gbureck U (2016) Strength reliability and in vitro degradation of three-dimensional powder printed strontium-substituted magnesium phosphate scaffolds. Acta Biomater 31:401–411CrossRef
41.
Creagh LT, McDonald M (2003) Design and performance of inkjet print heads for non-graphic-arts applications. MRS Bull 28:807–811CrossRef
42.
de Gans BJ, Duineveld PC, Schubert US (2004) Inkjet printing of polymers: state of the art and future developments. Adv Mater 16:203–213CrossRef
43.
Lu K, Reynolds WT (2008) 3DP process for fine mesh structure printing. Powder Technol 187:11–18CrossRef
44.
Boyan BD, Hummert TW, Dean DD, Schwartz Z (1996) Role of material surfaces in regulating bone and cartilage cell response. Biomaterials 17:137–146CrossRef
45.
Will J, Melcher R, Treul C, Travitzky N, Kneser U, Polykandriotis E et al (2008) Porous ceramic bone scaffolds for vascularized bone tissue regeneration. J Mater Sci Mater Med 19:2781–2790CrossRef
46.
Suwanprateeb J, Sanngam R, Panyathanmaporn T (2010) Influence of raw powder preparation routes on properties of hydroxyapatite fabricated by 3D printing technique. Mater Sci Eng C Mater Biol Appl 30:610–617CrossRef
47.
Fielding GA, Bandyopadhyay A, Bose S (2012) Effects of silica and zinc oxide doping on mechanical and biological properties of 3D printed tricalcium phosphate tissue engineering scaffolds. Dent Mater 28:113–122CrossRef
48.
Vorndran E, Klarner M, Klammert U, Grover LM, Patel S, Barralet JE et al (2008) 3D powder printing of beta-tricalcium phosphate ceramics using different strategies. Adv Eng Mater 10:B67–B71CrossRef
49.
Castilho M, Moseke C, Ewald A, Gbureck U, Groll J, Pires I et al (2014) Direct 3D powder printing of biphasic calcium phosphate scaffolds for substitution of complex bone defects. Biofabrication 6
50.
Seitz H, Deisinger U, Leukers B, Detsch R, Ziegler G (2009) Different calcium phosphate granules for 3-D printing of bone tissue engineering scaffolds. Adv Eng Mater 11:B41–B46CrossRef
51.
Gbureck U, Hoelzel T, Biermann I, Barralet JE, Grover LM (2008) Preparation of tricalcium phosphate/calcium pyrophosphate structures via rapid prototyping. J Mater Sci Mater Med 19:1559–1563CrossRef
52.
Shanjani Y, De Croos JNA, Pilliar RM, Kandel RA, Toyserkani E (2010) Solid freeform fabrication and characterization of porous calcium polyphosphate structures for tissue engineering purposes. J Biomed Mater Res Part B Appl Biomater 93B:510–519CrossRef
53.
Detsch R, Schaefer S, Deisinger U, Ziegler G, Seitz H, Leukers B (2011) In vitro-osteoclastic activity studies on surfaces of 3D printed calcium phosphate scaffolds. J Biomater Appl 26:359–380CrossRef
54.
Tay BY, Evans JRG, Edirisinghe MJ (2003) Solid freeform fabrication of ceramics. Int Mater Rev 48:341–370CrossRef
55.
Mandal S, Meininger S, Gbureck U, Basu B (2018) 3D powder printed tetracalcium phosphate scaffold with phytic acid binder: fabrication, microstructure and in situ X-ray tomography analysis of compressive failure. J Mater Sci Mater Med 29
56.
Vella JB, Trombetta RP, Hoffman MD, Inzana J, Awad H, Benoit DSW (2018) Three dimensional printed calcium phosphate and poly(caprolactone) composites with improved mechanical properties and preserved microstructure. J Biomed Mater Res Part A 106:663–672CrossRef
57.
Klammert U, Reuther T, Jahn C, Kraski B, Kubler AC, Gbureck U (2009) Cytocompatibility of brushite and monetite cell culture scaffolds made by three-dimensional powder printing. Acta Biomater 5:727–734CrossRef
58.
Habibovic P, Gbureck U, Doillon CJ, Bassett DC, van Blitterswijk CA, Barralet JE (2008) Osteoconduction and osteoinduction of low-temperature 3D printed bioceramic implants. Biomaterials 29:944–953CrossRef
59.
Fielding G, Bose S (2013) SiO2 and ZnO dopants in three-dimensionally printed tricalcium phosphate bone tissue engineering scaffolds enhance osteogenesis and angiogenesis in vivo. Acta Biomater 9:9137–9148CrossRef
60.
Bose S, Banerjee D, Robertson S, Vahabzadeh S (2018) Enhanced in vivo bone and blood vessel formation by iron oxide and silica doped 3D printed tricalcium phosphate scaffolds. Ann Biomed Eng 46:1241–1253CrossRef
61.
Nandi SK, Fielding G, Banerjee D, Bandyopadhyay A, Bose S (2018) 3D-printed beta-TCP bone tissue engineering scaffolds: effects of chemistry on in vivo biological properties in a rabbit tibia model. J Mater Res 33:1939–1947CrossRef
62.
Torres J, Tamimi F, Alkhraisat MH, Prados-Frutos JC, Rastikerdar E, Gbureck U et al (2011) Vertical bone augmentation with 3D-synthetic monetite blocks in the rabbit calvaria. J Clin Periodontol 38:1147–1153CrossRef
63.
Castilho M, Dias M, Vorndran E, Gbureck U, Fernandes P, Pires I et al (2014) Application of a 3D printed customized implant for canine cruciate ligament treatment by tibial tuberosity advancement. Biofabrication 6
64.
Arcos D, Vallet-Regi M (2013) Bioceramics for drug delivery. Acta Mater 61:890–911CrossRef
65.
Barralet J, Gbureck U, Habibovic P, Vorndran E, Gerard C, Doillon CJ (2009) Angiogenesis in calcium phosphate scaffolds by inorganic copper ion release. Tissue Eng Part A 15:1601–1609CrossRef
66.
Uchida A, Shinto Y, Araki N, Ono K (1992) Slow release of anticancer drugs from porous calcium hydroxyapatite ceramic. J Orthop Res 10:440–445CrossRef
67.
Sudo A, Hasegawa M, Fukuda A, Uchida A (2008) Treatment of infected hip arthroplasty with antibiotic-impregnated calcium hydroxyapatite. J Arthroplasty 23:145–150CrossRef
68.
Gbureck U, Vorndran E, Muller FA, Barralet JE (2007) Low temperature direct 3D printed bioceramics and biocomposites as drug release matrices. J Control Release 122:173–180CrossRef
69.
Cornelsen M, Petersen S, Dietsch K, Rudolph A, Schmitz K, Sternberg K et al (2013) Infiltration of 3D printed tricalciumphosphate scaffolds with biodegradable polymers and biomolecules for local drug delivery. Biomed Eng Biomedizinische Technik 58
70.
Becker ST, Bolte H, Schuenemann K, Seitz H, Bara JJ, Beck-Broichsitter BE et al (2012) Endocultivation: the influence of delayed vs. simultaneous application of BMP-2 onto individually formed hydroxyapatite matrices for heterotopic bone induction. Int J Oral Maxillofac Surg 41:1153–1160
71.
Strobel LA, Rath SN, Maier AK, Beier JP, Arkudas A, Greil P et al (2014) Induction of bone formation in biphasic calcium phosphate scaffolds by bone morphogenetic protein-2 and primary osteoblasts. J Tissue Eng Regen Med 8:176–185CrossRef
72.
Shende P, Agrawal S (2018) Integration of 3D printing with dosage forms: a new perspective for modern healthcare. Biomed Pharmacother 107:146–154CrossRef
73.
Sandler N, Maattanen A, Ihalainen P, Kronberg L, Meierjohann A, Viitala T et al (2011) Inkjet printing of drug substances and use of porous substrates-towards individualized dosing. J Pharm Sci 100:3386–3395CrossRef
74.
Wu BM, Borland SW, Giordano RA, Cima LG, Sachs EM, Cima MJ (1996) Solid free-form fabrication of drug delivery devices. J Control Release 40:77–87CrossRef
75.
Yu DG, Yang XL, Huang WD, Liu J, Wang YG, Xu H (2007) Tablets with material gradients fabricated by three-dimensional printing. J Pharm Sci 96:2446–2456CrossRef
76.
Wu W, Zheng Q, Guo X, Sun J, Liu Y (2009) A programmed release multi-drug implant fabricated by three-dimensional printing technology for bone tuberculosis therapy. Biomed Mater 4
77.
Fuchs A (2013) MD thesis, University of Würzburg
78.
Kanter B, Geffers M, Ignatius A, Gbureck U (2014) Control of in vivo mineral bone cement degradation. Acta Biomater 10:3279–3287CrossRef
Metadaten
Titel
Low Temperature 3D Printing of Drug Loaded Bioceramic Scaffolds and Implants
verfasst von
Susanne Meininger
Elke Vorndran
Miguel Castilho
Paulo Rui Fernandes
Uwe Gbureck
Copyright-Jahr
2019
Buch
New Developments in Tissue Engineering and Regeneration

Print ISBN: 978-3-030-15370-0

Electronic ISBN: 978-3-030-15372-4

Copyright-Jahr: 2019

DOI
https://doi.org/10.1007/978-3-030-15372-4_4

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