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Cognitive Neurodynamics
Erschienen in: Cognitive Neurodynamics 4/2018

26.02.2018 | Research Article

Maintenance of postsynaptic neuronal excitability by a positive feedback loop of postsynaptic BDNF expression

verfasst von: Lijie Hao, Zhuoqin Yang, Pulin Gong, Jinzhi Lei

Erschienen in: Cognitive Neurodynamics | Ausgabe 4/2018

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Abstract

Experiments have demonstrated that in mice, the PVT strongly projects to the CeL and participates in the formation of fear memories by synaptic potentiation in the amygdala. Herein, we propose a mathematical model based on a positive feedback loop of BDNF expression and signaling to investigate PVT manipulation of synaptic potentiation. The model is validated by comparisons with experimental observations. We find that a high postsynaptic firing frequency after stimulation is induced by presynaptic \({\rm {Ca}^{2+}}\) when the rates of BDNF secretion from PVT and LA neurons to the CeL are above a threshold value. Moreover, the positive feedback of postsynaptic BDNF production is important for the maintenance of the high excitability of the \({\rm SOM^+}\) CeL neuron after stimulation. The model brings insight into the underlying mechanisms of PVT modulation of synaptic potentiation at LA-CeL synapses and provides a framework of understanding other similar processes associated with synaptic plasticity.
Vorheriger Artikel Influence of active synaptic pools on the single synaptic event
Nächster Artikel PCA based population generation for genetic network optimization

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Metadaten
Titel
Maintenance of postsynaptic neuronal excitability by a positive feedback loop of postsynaptic BDNF expression
verfasst von
Lijie Hao
Zhuoqin Yang
Pulin Gong
Jinzhi Lei
Publikationsdatum
26.02.2018
Verlag
Springer Netherlands
Erschienen in
Cognitive Neurodynamics / Ausgabe 4/2018
Print ISSN: 1871-4080
Elektronische ISSN: 1871-4099
DOI
https://doi.org/10.1007/s11571-018-9479-z

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