Skip to main content

2024 | OriginalPaper | Buchkapitel

Masking Language Model Mechanism with Event-Driven Knowledge Graphs for Temporal Relations Extraction from Clinical Narratives

verfasst von : Kanimozhi Uma, Sumam Francis, Marie-Francine Moens

Erschienen in: Complex Networks & Their Applications XII

Verlag: Springer Nature Switzerland

Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.

search-config
loading …

Abstract

For many natural language processing systems, the extraction of temporal links and associations from clinical narratives has been a critical challenge. To understand such processes, we must be aware of the occurrences of events and their time or temporal aspect by constructing a chronology for the sequence of events. The primary objective of temporal relation extraction is to identify relationships and correlations between entities, events, and expressions. We propose a novel architecture leveraging Transformer based graph neural network by combining textual data with event graph embeddings for predicting temporal links across events, entities, document creation time and expressions. We demonstrate our preliminary findings on i2b2 temporal relations corpus for predicting BEFORE, AFTER and OVERLAP links with event graph for correct set of relations. Comparison with various Biomedical-BERT embedding types were benchmarked yielding best performance on PubMed BERT with language model masking (LMM) mechanism on our methodology. This illustrates the effectiveness of our proposed strategy.

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 390 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Maschinenbau + Werkstoffe




 

Jetzt Wissensvorsprung sichern!

Springer Professional "Wirtschaft"

Online-Abonnement

Mit Springer Professional "Wirtschaft" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 340 Zeitschriften

aus folgenden Fachgebieten:

  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Versicherung + Risiko




Jetzt Wissensvorsprung sichern!

Fußnoten
1
emilyalsentzer/Bio_ClinicalBERT.
 
2
microsoft/BiomedNLP-PubMedBERT-base-uncased-abstract-fulltext.
 
3
bionlp/bluebert_pubmed_uncased_L-24_H-1024_A-16.
 
4
allenai/scibert_scivocab_uncased.
 
Literatur
3.
Zurück zum Zitat Galvan, D., Okazaki, N., Matsuda, K., Inui, K.: Investigating the challenges of temporal relation extraction from clinical text. In: Lavelli, A., Minard, A.-L., Rinaldi, F. (eds.) Proceedings of the Ninth International Workshop on Health Text Mining and Information Analysis, Louhi@EMNLP 2018, Brussels, Belgium, 31 October 2018, pp. 55–64. Association for Computational Linguistics (2018). https://doi.org/10.18653/v1/w18-5607 Galvan, D., Okazaki, N., Matsuda, K., Inui, K.: Investigating the challenges of temporal relation extraction from clinical text. In: Lavelli, A., Minard, A.-L., Rinaldi, F. (eds.) Proceedings of the Ninth International Workshop on Health Text Mining and Information Analysis, Louhi@EMNLP 2018, Brussels, Belgium, 31 October 2018, pp. 55–64. Association for Computational Linguistics (2018). https://​doi.​org/​10.​18653/​v1/​w18-5607
4.
Zurück zum Zitat Guan, H., Li, J., Xu, H., Devarakonda, M.V.: Robustly pre-trained neural model for direct temporal relation extraction. In: 9th IEEE International Conference on Healthcare Informatics, ICHI 2021, Victoria, BC, Canada, 9–12 August 2021, pp. 501–502. IEEE (2021). https://doi.org/10.1109/ICHI52183.2021.00090 Guan, H., Li, J., Xu, H., Devarakonda, M.V.: Robustly pre-trained neural model for direct temporal relation extraction. In: 9th IEEE International Conference on Healthcare Informatics, ICHI 2021, Victoria, BC, Canada, 9–12 August 2021, pp. 501–502. IEEE (2021). https://​doi.​org/​10.​1109/​ICHI52183.​2021.​00090
6.
Zurück zum Zitat Han, R., Hsu, I.-H., Yang, M., Galstyan, A., Weischedel, R.M., Peng, N.: Deep structured neural network for event temporal relation extraction. In: Bansal, M., Villavicencio, A. (eds.) Proceedings of the 23rd Conference on Computational Natural Language Learning, CoNLL 2019, Hong Kong, China, 3–4 November 2019, pp. 666–106. Association for Computational Linguistics (2019). https://doi.org/10.18653/v1/K19-1062 Han, R., Hsu, I.-H., Yang, M., Galstyan, A., Weischedel, R.M., Peng, N.: Deep structured neural network for event temporal relation extraction. In: Bansal, M., Villavicencio, A. (eds.) Proceedings of the 23rd Conference on Computational Natural Language Learning, CoNLL 2019, Hong Kong, China, 3–4 November 2019, pp. 666–106. Association for Computational Linguistics (2019). https://​doi.​org/​10.​18653/​v1/​K19-1062
7.
Zurück zum Zitat Han, R., Ning, Q., Peng, N.: Joint event and temporal relation extraction with shared representations and structured prediction. In: Inui, K., Jiang, J., Ng, V., Wan, X. (eds.) Proceedings of the 2019 Conference on Empirical Methods in Natural Language Processing and the 9th International Joint Conference on Natural Language Processing, EMNLP-IJCNLP 2019, Hong Kong, China, 3–7 November 2019, pp. 434–444. Association for Computational Linguistics (2019). https://doi.org/10.18653/v1/D19-1041 Han, R., Ning, Q., Peng, N.: Joint event and temporal relation extraction with shared representations and structured prediction. In: Inui, K., Jiang, J., Ng, V., Wan, X. (eds.) Proceedings of the 2019 Conference on Empirical Methods in Natural Language Processing and the 9th International Joint Conference on Natural Language Processing, EMNLP-IJCNLP 2019, Hong Kong, China, 3–7 November 2019, pp. 434–444. Association for Computational Linguistics (2019). https://​doi.​org/​10.​18653/​v1/​D19-1041
8.
Zurück zum Zitat Ul Haq, H., Kocaman, V., Talby, D.: Deeper clinical document understanding using relation extraction. CoRR abs/2112.13259 (2021). arXiv:2112.13259 Ul Haq, H., Kocaman, V., Talby, D.: Deeper clinical document understanding using relation extraction. CoRR abs/2112.13259 (2021). arXiv:​2112.​13259
10.
Zurück zum Zitat Leeuwenberg, A., Moens, M.-F.: Structured learning for temporal relation extraction from clinical records. In: Lapata, M., Blunsom, P., Koller, A. (eds.) Proceedings of the 15th Conference of the European Chapter of the Association for Computational Linguistics, EACL 2017, Volume 1: Long Papers, Valencia, Spain, 3–7 April 2017, pp. 1150–1158. Association for Computational Linguistics (2017). https://doi.org/10.18653/v1/e17-1108 Leeuwenberg, A., Moens, M.-F.: Structured learning for temporal relation extraction from clinical records. In: Lapata, M., Blunsom, P., Koller, A. (eds.) Proceedings of the 15th Conference of the European Chapter of the Association for Computational Linguistics, EACL 2017, Volume 1: Long Papers, Valencia, Spain, 3–7 April 2017, pp. 1150–1158. Association for Computational Linguistics (2017). https://​doi.​org/​10.​18653/​v1/​e17-1108
11.
Zurück zum Zitat Leeuwenberg, A., Moens, M.-F.: Temporal information extraction by predicting relative time-lines. In: Riloff, E., Chiang, D., Hockenmaier, J., Tsujii, J. (eds.) Proceedings of the 2018 Conference on Empirical Methods in Natural Language Processing, Brussels, Belgium, 31 October–4 November 2018, pp. 1237–1246. Association for Computational Linguistics (2018). https://doi.org/10.18653/v1/d18-1155 Leeuwenberg, A., Moens, M.-F.: Temporal information extraction by predicting relative time-lines. In: Riloff, E., Chiang, D., Hockenmaier, J., Tsujii, J. (eds.) Proceedings of the 2018 Conference on Empirical Methods in Natural Language Processing, Brussels, Belgium, 31 October–4 November 2018, pp. 1237–1246. Association for Computational Linguistics (2018). https://​doi.​org/​10.​18653/​v1/​d18-1155
12.
Zurück zum Zitat Lin, C., Miller, T., Dligach, D., Bethard, S., Savova, G.: A BERT-based universal model for both within-and cross-sentence clinical temporal relation extraction. In: Proceedings of the 2nd Clinical Natural Language Processing Workshop, pp. 65–71 (2019) Lin, C., Miller, T., Dligach, D., Bethard, S., Savova, G.: A BERT-based universal model for both within-and cross-sentence clinical temporal relation extraction. In: Proceedings of the 2nd Clinical Natural Language Processing Workshop, pp. 65–71 (2019)
13.
Zurück zum Zitat Lin, C., Miller, T., Dligach, D., Sadeque, F., Bethard, S., Savova, G.: A BERT-based one-pass multi-task model for clinical temporal relation extraction (2020) Lin, C., Miller, T., Dligach, D., Sadeque, F., Bethard, S., Savova, G.: A BERT-based one-pass multi-task model for clinical temporal relation extraction (2020)
14.
Zurück zum Zitat Lin, C., Miller, T.A., Dligach, D., Amiri, H., Bethard, S., Savova, G.: Self-training improves recurrent neural networks performance for temporal relation extraction. In: Lavelli, A., Minard, A.-L., Rinaldi, F. (eds.) Proceedings of the Ninth International Workshop on Health Text Mining and Information Analysis, Louhi@EMNLP 2018, Brussels, Belgium, 31 October 2018, pp. 165–176. Association for Computational Linguistics (2018). https://doi.org/10.18653/v1/w18-5619 Lin, C., Miller, T.A., Dligach, D., Amiri, H., Bethard, S., Savova, G.: Self-training improves recurrent neural networks performance for temporal relation extraction. In: Lavelli, A., Minard, A.-L., Rinaldi, F. (eds.) Proceedings of the Ninth International Workshop on Health Text Mining and Information Analysis, Louhi@EMNLP 2018, Brussels, Belgium, 31 October 2018, pp. 165–176. Association for Computational Linguistics (2018). https://​doi.​org/​10.​18653/​v1/​w18-5619
15.
Zurück zum Zitat Lin, C., Miller, T.A., Dligach, D., Bethard, S., Savova, G.: Representations of time expressions for temporal relation extraction with convolutional neural networks. In: Cohen, K.B., Demner-Fushman, D., Ananiadou, S., Tsujii, J. (eds.) BioNLP 2017, Vancouver, Canada, 4 August 2017, pp. 322–327. Association for Computational Linguistics (2017). https://doi.org/10.18653/v1/W17-2341 Lin, C., Miller, T.A., Dligach, D., Bethard, S., Savova, G.: Representations of time expressions for temporal relation extraction with convolutional neural networks. In: Cohen, K.B., Demner-Fushman, D., Ananiadou, S., Tsujii, J. (eds.) BioNLP 2017, Vancouver, Canada, 4 August 2017, pp. 322–327. Association for Computational Linguistics (2017). https://​doi.​org/​10.​18653/​v1/​W17-2341
16.
Zurück zum Zitat Lin, C., Miller, T.A., Dligach, D., Bethard, S., Savova, G.: EntityBERT: entity-centric masking strategy for model pretraining for the clinical domain. In: Demner-Fushman, D., Cohen, K.B., Ananiadou, S., Tsujii, J. (eds.) Proceedings of the 20th Workshop on Biomedical Language Processing, BioNLP@NAACL-HLT 2021, Online, 11 June 2021, pp. 191–201. Association for Computational Linguistics (2021). https://doi.org/10.18653/v1/2021.bionlp-1.21 Lin, C., Miller, T.A., Dligach, D., Bethard, S., Savova, G.: EntityBERT: entity-centric masking strategy for model pretraining for the clinical domain. In: Demner-Fushman, D., Cohen, K.B., Ananiadou, S., Tsujii, J. (eds.) Proceedings of the 20th Workshop on Biomedical Language Processing, BioNLP@NAACL-HLT 2021, Online, 11 June 2021, pp. 191–201. Association for Computational Linguistics (2021). https://​doi.​org/​10.​18653/​v1/​2021.​bionlp-1.​21
17.
Zurück zum Zitat Man, H., Ngo, N.T., Van, L.N., Nguyen, T.H.: Selecting optimal context sentences for event-event relation extraction. In: Thirty-Sixth AAAI Conference on Artificial Intelligence, AAAI 2022, Thirty-Fourth Conference on Innovative Applications of Artificial Intelligence, IAAI 2022, The Twelveth Symposium on Educational Advances in Artificial Intelligence, EAAI 2022, Virtual Event, 22 February–1 March 2022, pp. 11058–11066. AAAI Press (2022). https://ojs.aaai.org/index.php/AAAI/article/view/21354 Man, H., Ngo, N.T., Van, L.N., Nguyen, T.H.: Selecting optimal context sentences for event-event relation extraction. In: Thirty-Sixth AAAI Conference on Artificial Intelligence, AAAI 2022, Thirty-Fourth Conference on Innovative Applications of Artificial Intelligence, IAAI 2022, The Twelveth Symposium on Educational Advances in Artificial Intelligence, EAAI 2022, Virtual Event, 22 February–1 March 2022, pp. 11058–11066. AAAI Press (2022). https://​ojs.​aaai.​org/​index.​php/​AAAI/​article/​view/​21354
18.
Zurück zum Zitat Mathur, P., Jain, R., Dernoncourt, F., Morariu, V.I., Tran, Q.H., Manocha, D.: TIMERS: document-level temporal relation extraction. In: Zong, C., Xia, F., Li, W., Navigli, R. (eds.) Proceedings of the 59th Annual Meeting of the Association for Computational Linguistics and the 11th International Joint Conference on Natural Language Processing, ACL/IJCNLP 2021, Volume 2: Short Papers, Virtual Event, 1–6 August 2021, pp. 524–533. Association for Computational Linguistics (2021). https://doi.org/10.18653/v1/2021.acl-short.67 Mathur, P., Jain, R., Dernoncourt, F., Morariu, V.I., Tran, Q.H., Manocha, D.: TIMERS: document-level temporal relation extraction. In: Zong, C., Xia, F., Li, W., Navigli, R. (eds.) Proceedings of the 59th Annual Meeting of the Association for Computational Linguistics and the 11th International Joint Conference on Natural Language Processing, ACL/IJCNLP 2021, Volume 2: Short Papers, Virtual Event, 1–6 August 2021, pp. 524–533. Association for Computational Linguistics (2021). https://​doi.​org/​10.​18653/​v1/​2021.​acl-short.​67
19.
Zurück zum Zitat Ning, Q., Feng, Z., Roth, D.: A structured learning approach to temporal relation extraction. In: Palmer, M., Hwa, R., Riedel, S. (eds.) Proceedings of the 2017 Conference on Empirical Methods in Natural Language Processing, EMNLP 2017, Copenhagen, Denmark, 9–11 September 2017, pp. 1027–1037. Association for Computational Linguistics (2017). https://doi.org/10.18653/v1/d17-1108 Ning, Q., Feng, Z., Roth, D.: A structured learning approach to temporal relation extraction. In: Palmer, M., Hwa, R., Riedel, S. (eds.) Proceedings of the 2017 Conference on Empirical Methods in Natural Language Processing, EMNLP 2017, Copenhagen, Denmark, 9–11 September 2017, pp. 1027–1037. Association for Computational Linguistics (2017). https://​doi.​org/​10.​18653/​v1/​d17-1108
20.
Zurück zum Zitat Peng, Y., Yan, S., Lu, Z.: Transfer learning in biomedical natural language processing: an evaluation of BERT and ELMo on ten benchmarking datasets. In: Demner-Fushman, D., Cohen, K.B., Ananiadou, S., Tsujii, J. (eds.) Proceedings of the 18th BioNLP Workshop and Shared Task, BioNLP@ACL 2019, Florence, Italy, 1 August 2019, pp. 58–65. Association for Computational Linguistics (2019). https://doi.org/10.18653/v1/w19-5006 Peng, Y., Yan, S., Lu, Z.: Transfer learning in biomedical natural language processing: an evaluation of BERT and ELMo on ten benchmarking datasets. In: Demner-Fushman, D., Cohen, K.B., Ananiadou, S., Tsujii, J. (eds.) Proceedings of the 18th BioNLP Workshop and Shared Task, BioNLP@ACL 2019, Florence, Italy, 1 August 2019, pp. 58–65. Association for Computational Linguistics (2019). https://​doi.​org/​10.​18653/​v1/​w19-5006
21.
Zurück zum Zitat Pennington, J., Socher, R., Manning, C.D.: GloVe: global vectors for word representation. In: Moschitti, A., Pang, B., Daelemans, W., (eds.) Proceedings of the 2014 Conference on Empirical Methods in Natural Language Processing, EMNLP 2014, A meeting of SIGDAT, a Special Interest Group of the ACL, 25–29 October 2014, Doha, Qatar, pp. 1532–1543. ACL (2014). https://doi.org/10.3115/v1/d14-1162 Pennington, J., Socher, R., Manning, C.D.: GloVe: global vectors for word representation. In: Moschitti, A., Pang, B., Daelemans, W., (eds.) Proceedings of the 2014 Conference on Empirical Methods in Natural Language Processing, EMNLP 2014, A meeting of SIGDAT, a Special Interest Group of the ACL, 25–29 October 2014, Doha, Qatar, pp. 1532–1543. ACL (2014). https://​doi.​org/​10.​3115/​v1/​d14-1162
24.
Zurück zum Zitat Tourille, J., Ferret, O., Névéol, A., Tannier, X.: Neural architecture for temporal relation extraction: a Bi-LSTM approach for detecting narrative containers. In: Barzilay, R., Kan, M.-Y. (eds.) Proceedings of the 55th Annual Meeting of the Association for Computational Linguistics, ACL 2017, Volume 2: Short Papers, Vancouver, Canada, 30 July–4 August, pp. 224–230. Association for Computational Linguistics (2017). https://doi.org/10.18653/v1/P17-2035 Tourille, J., Ferret, O., Névéol, A., Tannier, X.: Neural architecture for temporal relation extraction: a Bi-LSTM approach for detecting narrative containers. In: Barzilay, R., Kan, M.-Y. (eds.) Proceedings of the 55th Annual Meeting of the Association for Computational Linguistics, ACL 2017, Volume 2: Short Papers, Vancouver, Canada, 30 July–4 August, pp. 224–230. Association for Computational Linguistics (2017). https://​doi.​org/​10.​18653/​v1/​P17-2035
25.
Zurück zum Zitat Wang, L., Li, P., Xu, S.: DCT-centered temporal relation extraction. In: Calzolari, N., et al. (eds.) Proceedings of the 29th International Conference on Computational Linguistics, COLING 2022, Gyeongju, Republic of Korea, 12–17 October 2022, pp. 2087–2097. International Committee on Computational Linguistics (2022). https://aclanthology.org/2022.coling-1.182 Wang, L., Li, P., Xu, S.: DCT-centered temporal relation extraction. In: Calzolari, N., et al. (eds.) Proceedings of the 29th International Conference on Computational Linguistics, COLING 2022, Gyeongju, Republic of Korea, 12–17 October 2022, pp. 2087–2097. International Committee on Computational Linguistics (2022). https://​aclanthology.​org/​2022.​coling-1.​182
26.
Zurück zum Zitat Wang, M., et al.: Deep graph library: a graph-centric, highly-performant package for graph neural networks. arXiv preprint arXiv:1909.01315 (2019) Wang, M., et al.: Deep graph library: a graph-centric, highly-performant package for graph neural networks. arXiv preprint arXiv:​1909.​01315 (2019)
27.
Zurück zum Zitat Zhang, S., Ning, Q., Huang, L.: Extracting temporal event relation with syntax-guided graph transformer. In: Carpuat, M., de Marneffe, M.-C., Ruíz, I.V.M. (eds.) Findings of the Association for Computational Linguistics, NAACL 2022, Seattle, WA, United States, 10–15 July 2022, pp. 379–390. Association for Computational Linguistics (2022). https://doi.org/10.18653/v1/2022.findings-naacl.29 Zhang, S., Ning, Q., Huang, L.: Extracting temporal event relation with syntax-guided graph transformer. In: Carpuat, M., de Marneffe, M.-C., Ruíz, I.V.M. (eds.) Findings of the Association for Computational Linguistics, NAACL 2022, Seattle, WA, United States, 10–15 July 2022, pp. 379–390. Association for Computational Linguistics (2022). https://​doi.​org/​10.​18653/​v1/​2022.​findings-naacl.​29
28.
Zurück zum Zitat Zhao, X., Lin, S.-T., Durrett, G.: Effective distant supervision for temporal relation extraction. CoRR abs/2010.12755. arXiv arXiv:2010.12755 (2020) Zhao, X., Lin, S.-T., Durrett, G.: Effective distant supervision for temporal relation extraction. CoRR abs/2010.12755. arXiv arXiv:​2010.​12755 (2020)
29.
Zurück zum Zitat Zhou, Y., et al.: Clinical temporal relation extraction with probabilistic soft logic regularization and global inference. In: Thirty-Fifth AAAI Conference on Artificial Intelligence, AAAI 2021, Thirty-Third Conference on Innovative Applications of Artificial Intelligence, IAAI 2021, The Eleventh Symposium on Educational Advances in Artificial Intelligence, EAAI 2021, Virtual Event, 2–9 February 2021, pp. 14647–14655. AAAI Press (2021). https://ojs.aaai.org/index.php/AAAI/article/view/177212023-09-1109:46 Zhou, Y., et al.: Clinical temporal relation extraction with probabilistic soft logic regularization and global inference. In: Thirty-Fifth AAAI Conference on Artificial Intelligence, AAAI 2021, Thirty-Third Conference on Innovative Applications of Artificial Intelligence, IAAI 2021, The Eleventh Symposium on Educational Advances in Artificial Intelligence, EAAI 2021, Virtual Event, 2–9 February 2021, pp. 14647–14655. AAAI Press (2021). https://​ojs.​aaai.​org/​index.​php/​AAAI/​article/​view/​177212023-09-1109:​46
Metadaten
Titel
Masking Language Model Mechanism with Event-Driven Knowledge Graphs for Temporal Relations Extraction from Clinical Narratives
verfasst von
Kanimozhi Uma
Sumam Francis
Marie-Francine Moens
Copyright-Jahr
2024
DOI
https://doi.org/10.1007/978-3-031-53468-3_14

Premium Partner