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Erschienen in:
2019 | OriginalPaper | Buchkapitel
Mathematical Modelling of HIV Within-Host Evolution
verfasst von : Anna Maria Riera-Escandell, Andrei Korobeinikov
Erschienen in: Extended Abstracts Spring 2018
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Abstract
The majority of hypotheses suggested to explain the human immunodeficiency virus (HIV) progression explains the particularities of the disease by a very high mutability and evolvability of the virus. For HIV, several mechanisms of mutation are possible, and it is reasonable to assume that a mechanistic mathematical model of HIV evolution reflect these mechanisms. In this contribution, we formulate three different mathematical models of within-host HIV evolution that corresponds to three different virus mutation mechanisms. Simulations demonstrate that, for realistic rates of evolution, either of the three models leads to a very similar (and for some models to identical) outcome and, hence, only one of the mechanisms (presumably, the simplest one) can be used in simulations.