In response to DNA damage, the cell initiates a series of enzymatic reactions designed to repair its genetic structure and restore its normal function. In some cases, the metabolic consequences of these reactions can so drastically perturb cellular homeostasis that they lead to cell death. It is important to understand these biochemical processes in order to design rational approaches to alter their course.
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- Metabolic Protection Against Rapid Cell Death Induced by High Level DNA Damage
Nathan A. Berger
Sosamma J. Berger
Donna C. Sudar
- Springer US