2015 | OriginalPaper | Buchkapitel
Microscopic Tubular Cell Organization for Artificial Vascularization
verfasst von : Darong Oh, Suwon Lee, Kyo-In Koo, Jong-Mo Seo
Erschienen in: 6th European Conference of the International Federation for Medical and Biological Engineering
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We propose a simple method for forming fibroblast (NIH/3T3)-laden alginate lumen gels using a coaxial laminar flow for artificial vascularization, and was evaluated using confocal microscope As increasing the sodium alginate flow rates, the average outer diameters of the composed micro-tubes determined by the thickness of the injecting material, decreased. We mixed NIH/3T3 to gels and were alive during 4 days of cell culture, and this showed fibroblast cells to be well-organized and cultured maintaining the blood-vessel shape. The proposed technique could further be applied to an endothelial co-culturing system for mimicking the real blood vessel.