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Journal of Polymer Research

Erschienen in:

01.07.2014 | Original Paper

Mixed micellar nanoparticles based on PCL-PEG-PPO-PEG-PCL pentablocks

verfasst von: Salman Hassanzadeh, Sepideh Khoee, Vahid Farrokhi, Mohamad Mahdavi, Alireza Foroumadi

Erschienen in: Journal of Polymer Research | Ausgabe 7/2014

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Abstract

In an attempt to assess the limitations of pure F-68 pluronic nanoparticles and make use of their benefits, the mixed micelles of F-68 with polycaprolactone (PCL) homopolymer, mono-methoxy poly (ethylene glycol)-block-PCL-block -mono-methoxy poly(ethylene glycol) triblock (mPEG-PCL-mPEG) and PCL-block–PEG-block-poly (propylene oxide)-block-PEG-block-PCL pentablock (PCL-PEG-PPO-PEG-PCL) copolymers were prepared separately. DSC studies of the mixed formulations together with loadings (using newly introduced parameters such as micelle encapsulation efficiency [MEE]), sizings, and release mechanism evaluations confirmed that the introduction of the synthesized pentablock copolymers, as a core-compatibilizer, in both pure and mixed micelles results to the multicomponent blend-like core with minimum order of chains. The compatibilized core using pentablocks can boost drug encapsulations, particle sizes, PDIs, and, finally, zero-order mono-mechanism release of loaded drug.

Vorheriger Artikel Photo-cured organic–inorganic hybrid composites of methacrylate-terminated 4-arm star-shaped ε-caprolactone oligomer and methacrylate- or thiol-substituted polysilsesquioxane

Nächster Artikel Comb-like crosslinked alkyl acrylates-vinyl acetate terpolymers for oil sorption

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Titel: Mixed micellar nanoparticles based on PCL-PEG-PPO-PEG-PCL pentablocks
verfasst von: Salman Hassanzadeh
Sepideh Khoee
Vahid Farrokhi
Mohamad Mahdavi
Alireza Foroumadi
Publikationsdatum: 01.07.2014
Verlag: Springer Netherlands
Erschienen in: Journal of Polymer Research / Ausgabe 7/2014
Print ISSN: 1022-9760
Elektronische ISSN: 1572-8935
DOI: https://doi.org/10.1007/s10965-014-0508-2

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