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Erschienen in:
2006 | OriginalPaper | Buchkapitel
Modelling the Influence of RKIP on the ERK Signalling Pathway Using the Stochastic Process Algebra PEPA
verfasst von : Muffy Calder, Stephen Gilmore, Jane Hillston
Erschienen in: Transactions on Computational Systems Biology VII
Verlag: Springer Berlin Heidelberg
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This paper examines the influence of the Raf Kinase Inhibitor Protein (RKIP) on the Extracellular signal Regulated Kinase (ERK) signalling pathway [5] through modelling in a Markovian process algebra, PEPA [11]. Two models of the system are presented, a reagent-centric view and a pathway-centric view. The models capture functionality at the level of subpathway, rather than at a molecular level. Each model affords a different perspective of the pathway and analysis. We demonstrate the two models to be formally equivalent using the timing-aware bisimulation defined over PEPA models and discuss the biological significance.