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2019 | OriginalPaper | Buchkapitel

Multi-scale Coarse-to-Fine Segmentation for Screening Pancreatic Ductal Adenocarcinoma

verfasst von : Zhuotun Zhu, Yingda Xia, Lingxi Xie, Elliot K. Fishman, Alan L. Yuille

Erschienen in: Medical Image Computing and Computer Assisted Intervention – MICCAI 2019

Verlag: Springer International Publishing

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Abstract

We propose an intuitive approach of detecting pancreatic ductal adenocarcinoma (PDAC), the most common type of pancreatic cancer, by checking abdominal CT scans. Our idea is named multi-scale segmentation-for-classification, which classifies volumes by checking if at least a sufficient number of voxels is segmented as tumors, by which we can provide radiologists with tumor locations. In order to deal with tumors with different scales, we train and test our volumetric segmentation networks with multi-scale inputs in a coarse-to-fine flowchart. A post-processing module is used to filter out outliers and reduce false alarms. We collect a new dataset containing 439 CT scans, in which 136 cases were diagnosed with PDAC and 303 cases are normal, which is the largest set for PDAC tumors to the best of our knowledge. To offer the best trade-off between sensitivity and specificity, our proposed framework reports a sensitivity of \(94.1\%\) at a specificity of \(98.5\%\), which demonstrates the potential to make a clinical impact.

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Literatur
1.
Zurück zum Zitat Chen, L.C., Papandreou, G., Kokkinos, I., Murphy, K., Yuille, A.L.: Deeplab: semantic image segmentation with deep convolutional nets, atrous convolution, and fully connected CRFs. In: ICLR (2016) Chen, L.C., Papandreou, G., Kokkinos, I., Murphy, K., Yuille, A.L.: Deeplab: semantic image segmentation with deep convolutional nets, atrous convolution, and fully connected CRFs. In: ICLR (2016)
2.
Zurück zum Zitat Çiçek, Ö., Abdulkadir, A., Lienkamp, S.S., Brox, T., Ronneberger, O.: 3D U-net: learning dense volumetric segmentation from sparse annotation. In: Ourselin, S., Joskowicz, L., Sabuncu, M.R., Unal, G., Wells, W. (eds.) MICCAI 2016. LNCS, vol. 9901, pp. 424–432. Springer, Cham (2016). https://doi.org/10.1007/978-3-319-46723-8_49CrossRef Çiçek, Ö., Abdulkadir, A., Lienkamp, S.S., Brox, T., Ronneberger, O.: 3D U-net: learning dense volumetric segmentation from sparse annotation. In: Ourselin, S., Joskowicz, L., Sabuncu, M.R., Unal, G., Wells, W. (eds.) MICCAI 2016. LNCS, vol. 9901, pp. 424–432. Springer, Cham (2016). https://​doi.​org/​10.​1007/​978-3-319-46723-8_​49CrossRef
3.
Zurück zum Zitat Dou, Q., Chen, H., Yu, L., Qin, J., Heng, P.A.: Multilevel contextual 3-D CNNs for false positive reduction in pulmonary nodule detection. IEEE TBE 64, 1558–1567 (2017)CrossRef Dou, Q., Chen, H., Yu, L., Qin, J., Heng, P.A.: Multilevel contextual 3-D CNNs for false positive reduction in pulmonary nodule detection. IEEE TBE 64, 1558–1567 (2017)CrossRef
4.
Zurück zum Zitat Hussein, S., Chuquicusma, M.M., Kandel, P., Bolan, C.W., Wallace, M.B., Bagci, U.: Supervised and unsupervised tumor characterization in the deep learning era. arXiv:1801.03230 (2018) Hussein, S., Chuquicusma, M.M., Kandel, P., Bolan, C.W., Wallace, M.B., Bagci, U.: Supervised and unsupervised tumor characterization in the deep learning era. arXiv:​1801.​03230 (2018)
5.
Zurück zum Zitat Krizhevsky, A., Sutskever, I., Hinton, G.E.: Imagenet classification with deep convolutional neural networks. In: NIPS (2012) Krizhevsky, A., Sutskever, I., Hinton, G.E.: Imagenet classification with deep convolutional neural networks. In: NIPS (2012)
6.
Zurück zum Zitat Milletari, F., Navab, N., Ahmadi, S.A.: V-net: fully convolutional neural networks for volumetric medical image segmentation. In: 3DV (2016) Milletari, F., Navab, N., Ahmadi, S.A.: V-net: fully convolutional neural networks for volumetric medical image segmentation. In: 3DV (2016)
7.
Zurück zum Zitat PDQ Adult Treatment Editorial Board: Pancreatic cancer treatment (PDQ®) PDQ Adult Treatment Editorial Board: Pancreatic cancer treatment (PDQ®)
10.
Zurück zum Zitat Roth, H.R., Lu, L., Farag, A., Sohn, A., Summers, R.M.: Spatial aggregation of holistically-nested networks for automated pancreas segmentation. In: Ourselin, S., Joskowicz, L., Sabuncu, M.R., Unal, G., Wells, W. (eds.) MICCAI 2016. LNCS, vol. 9901, pp. 451–459. Springer, Cham (2016). https://doi.org/10.1007/978-3-319-46723-8_52CrossRef Roth, H.R., Lu, L., Farag, A., Sohn, A., Summers, R.M.: Spatial aggregation of holistically-nested networks for automated pancreas segmentation. In: Ourselin, S., Joskowicz, L., Sabuncu, M.R., Unal, G., Wells, W. (eds.) MICCAI 2016. LNCS, vol. 9901, pp. 451–459. Springer, Cham (2016). https://​doi.​org/​10.​1007/​978-3-319-46723-8_​52CrossRef
11.
Zurück zum Zitat Stewart, B.W.K.P., Wild, C.P., et al.: World cancer report 2014. Health (2017) Stewart, B.W.K.P., Wild, C.P., et al.: World cancer report 2014. Health (2017)
12.
Zurück zum Zitat Xia, Y., Xie, L., Liu, F., Zhu, Z., Fishman, E.K., Yuille, A.L.: Bridging the gap between 2D and 3D organ segmentation with volumetric fusion net. In: Frangi, A.F., Schnabel, J.A., Davatzikos, C., Alberola-López, C., Fichtinger, G. (eds.) MICCAI 2018. LNCS, vol. 11073, pp. 445–453. Springer, Cham (2018). https://doi.org/10.1007/978-3-030-00937-3_51CrossRef Xia, Y., Xie, L., Liu, F., Zhu, Z., Fishman, E.K., Yuille, A.L.: Bridging the gap between 2D and 3D organ segmentation with volumetric fusion net. In: Frangi, A.F., Schnabel, J.A., Davatzikos, C., Alberola-López, C., Fichtinger, G. (eds.) MICCAI 2018. LNCS, vol. 11073, pp. 445–453. Springer, Cham (2018). https://​doi.​org/​10.​1007/​978-3-030-00937-3_​51CrossRef
13.
Zurück zum Zitat Zhang, L., Lu, L., Summers, R.M., Kebebew, E., Yao, J.: Personalized pancreatic tumor growth prediction via group learning. In: Descoteaux, M., Maier-Hein, L., Franz, A., Jannin, P., Collins, D.L., Duchesne, S. (eds.) MICCAI 2017. LNCS, vol. 10434, pp. 424–432. Springer, Cham (2017). https://doi.org/10.1007/978-3-319-66185-8_48CrossRef Zhang, L., Lu, L., Summers, R.M., Kebebew, E., Yao, J.: Personalized pancreatic tumor growth prediction via group learning. In: Descoteaux, M., Maier-Hein, L., Franz, A., Jannin, P., Collins, D.L., Duchesne, S. (eds.) MICCAI 2017. LNCS, vol. 10434, pp. 424–432. Springer, Cham (2017). https://​doi.​org/​10.​1007/​978-3-319-66185-8_​48CrossRef
14.
Zurück zum Zitat Zhou, Y., Xie, L., Fishman, E.K., Yuille, A.L.: Deep supervision for pancreatic cyst segmentation in abdominal CT scans. In: Descoteaux, M., Maier-Hein, L., Franz, A., Jannin, P., Collins, D.L., Duchesne, S. (eds.) MICCAI 2017. LNCS, vol. 10435, pp. 222–230. Springer, Cham (2017). https://doi.org/10.1007/978-3-319-66179-7_26CrossRef Zhou, Y., Xie, L., Fishman, E.K., Yuille, A.L.: Deep supervision for pancreatic cyst segmentation in abdominal CT scans. In: Descoteaux, M., Maier-Hein, L., Franz, A., Jannin, P., Collins, D.L., Duchesne, S. (eds.) MICCAI 2017. LNCS, vol. 10435, pp. 222–230. Springer, Cham (2017). https://​doi.​org/​10.​1007/​978-3-319-66179-7_​26CrossRef
15.
Zurück zum Zitat Zhu, Z., Xia, Y., Shen, W., Fishman, E.K., Yuille, A.L.: A 3D coarse-to-fine framework for volumetric medical image segmentation. In: 3DV (2018) Zhu, Z., Xia, Y., Shen, W., Fishman, E.K., Yuille, A.L.: A 3D coarse-to-fine framework for volumetric medical image segmentation. In: 3DV (2018)
Metadaten
Titel
Multi-scale Coarse-to-Fine Segmentation for Screening Pancreatic Ductal Adenocarcinoma
verfasst von
Zhuotun Zhu
Yingda Xia
Lingxi Xie
Elliot K. Fishman
Alan L. Yuille
Copyright-Jahr
2019
DOI
https://doi.org/10.1007/978-3-030-32226-7_1

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