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Erschienen in:
2009 | OriginalPaper | Buchkapitel
Multivariate Tensor-Based Brain Anatomical Surface Morphometry via Holomorphic One-Forms
verfasst von : Yalin Wang, Tony F. Chan, Arthur W. Toga, Paul M. Thompson
Erschienen in: Medical Image Computing and Computer-Assisted Intervention – MICCAI 2009
Verlag: Springer Berlin Heidelberg
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Here we introduce multivariate tensor-based surface morphometry using holomorphic one-forms to study brain anatomy. We computed new statistics from the Riemannian metric tensors that retain the full information in the deformation tensor fields. We introduce two different holomorphic one-forms that induce different surface conformal parameterizations. We applied this framework to 3D MRI data to analyze hippocampal surface morphometry in Alzheimer’s Disease (AD; 26 subjects), lateral ventricular surface morphometry in HIV/AIDS (19 subjects) and cortical surface morphometry in Williams Syndrome (WS; 80 subjects). Experimental results demonstrated that our method powerfully detected brain surface abnormalities. Multivariate statistics on the local tensors outperformed other TBM methods including analysis of the Jacobian determinant, the largest eigenvalue, or the pair of eigenvalues, of the surface Jacobian matrix.