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Journal of Nanoparticle Research
Erschienen in: Journal of Nanoparticle Research 5/2013

01.05.2013 | Brief Communication

Nanodumbbells as multi-functional diagnosis probes

verfasst von: Hui Wang, Sakandar Rauf, Harish Padmanabhan, Krassen Dimitrov

Erschienen in: Journal of Nanoparticle Research | Ausgabe 5/2013

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Abstract

In this study, we present a method to generate multi-functional nanometre dumbbell structure, which comprises a cobalt magnetic and a gold nanoparticle bridged by target biomarker. Both cobalt magnetic and gold nanoparticles were successfully modified with two different monoclonal antibodies, which will specifically bind to target antigen. ELISA results confirmed that the activities of those antibodies were not lost due to the conjugation to nanoparticles. The formation of dumbbell structure with the presence of target biomarker molecule was demonstrated via scanning electron microscope. The success of this study allows us to apply this featured dumbbell structure into a nanoelectrode device for digital detection of diagnostic biomarker in the next step.
Vorheriger Artikel Preparation of carbon-coated copper nanoparticles by detonation decomposition of copper ion doped sol–gel explosive precursors
Nächster Artikel Catalytic growth of carbon nanofibers on Cr nanoparticles on a carbon substrate: adsorbents for organic dyes in water

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Metadaten
Titel
Nanodumbbells as multi-functional diagnosis probes
verfasst von
Hui Wang
Sakandar Rauf
Harish Padmanabhan
Krassen Dimitrov
Publikationsdatum
01.05.2013
Verlag
Springer Netherlands
Erschienen in
Journal of Nanoparticle Research / Ausgabe 5/2013
Print ISSN: 1388-0764
Elektronische ISSN: 1572-896X
DOI
https://doi.org/10.1007/s11051-013-1633-2

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