nach oben

Erschienen in:

2017 | OriginalPaper | Buchkapitel

4. Nanomolecular Diagnostics

verfasst von : Kewal K. Jain

Erschienen in: The Handbook of Nanomedicine

Verlag: Springer New York

Einloggen

Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.

search-config

KI-gestützte Suche

Aus

Abstract

Clinical application of molecular technologies to elucidate, diagnose and monitor human diseases is referred to as molecular diagnosis. It is a broader term than DNA (deoxyribonucleic acid) diagnostics and refers to the use of technologies that use DNA, RNA (ribonucleic acid), genes or proteins as bases for diagnostic tests. The scope of the subject is much wider and includes in vivo imaging and diagnosis at single molecule level. A more detailed description of molecular diagnostics is presented elsewhere (Jain 2017a).

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

über 102.000 Bücher
über 537 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Finance + Banking
Management + Führung
Marketing + Vertrieb
Maschinenbau + Werkstoffe
Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Jetzt informieren

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

über 67.000 Bücher
über 390 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Maschinenbau + Werkstoffe

Jetzt Wissensvorsprung sichern!

Jetzt informieren

Vorheriges Kapitel Nanotechnologies for Basic Research Relevant to Medicine

Nächstes Kapitel Nanopharmaceuticals

M AK, Jung S, Ji T. Protein biosensors based on polymer nanowires, carbon nanotubes and zinc oxide nanorods. Sensors (Basel). 2011;11:5087–111.CrossRef

Alam SR, Shah AS, Richards J, et al. Ultrasmall superparamagnetic particles of iron oxide in patients with acute myocardial infarction: early clinical experience. Circ Cardiovasc Imaging. 2012;5:559–65.CrossRef

Almutairi A, Rossin R, Shokeen M, et al. Biodegradable dendritic positron-emitting nanoprobes for the noninvasive imaging of angiogenesis. Proc Natl Acad Sci U S A. 2009;106:685–90.CrossRef

Avci O, Ünlü NL, Özkumur AY, Ünlü MS. Interferometric reflectance imaging sensor (IRIS) – a platform technology for multiplexed diagnostics and digital detection. Sensors (Basel). 2015;15:17649–65.CrossRef

Breitenstein M, Holzel R, Bier FF. Immobilization of different biomolecules by atomic force microscopy. J Nanobiotechnol. 2010;8:10.CrossRef

Butler TZ, Pavlenok M, Derrington IM, et al. Single-molecule DNA detection with an engineered MspA protein nanopore. Proc Natl Acad Sci U S A. 2008;105:20647–52.CrossRef

Byers RJ, Hitchman ER. Quantum dots brighten biological imaging. Prog Histochem Cytochem. 2011;45:201–37.CrossRef

Carbonaro A, Mohanty SK, Huang H, et al. Cell characterization using a protein-functionalized pore. Lab Chip. 2008;8:1478–85.CrossRef

Castaneda RT, Khurana A, Khan R, Daldrup-Link HE. Labeling stem cells with ferumoxytol, an FDA-approved iron oxide nanoparticle. J Vis Exp. 2011;57:e3482.

Chen J, Abell J, Huang YW, Zhao Y. On-chip ultra-thin layer chromatography and surface enhanced raman spectroscopy. Lab Chip. 2012;12:3096–102.CrossRef

Corstjens PL, de Dood CJ, van der Ploeg-van Schip JJ, et al. Lateral flow assay for simultaneous detection of cellular- and humoral immune responses. Clin Biochem. 2011;44:1241–6.CrossRef

Cunningham BT. Photonic crystal surfaces as a general purpose platform for label-free and fluorescent assays. JALA Charlottesv Va. 2010;15:120–35.

Dantham VR, Holler S, Barbre C, et al. Label-free detection of single protein using a nanoplasmonic-photonic hybrid microcavity. Nano Lett. 2013;13:3347–51.CrossRef

Debbage P, Jaschke W. Molecular imaging with nanoparticles: giant roles for dwarf actors. J Histochem Cell Biol. 2008;130:845–75.CrossRef

Delogu LG, Gemma L, Vidili G, et al. Functionalized multiwalled carbon nanotubes as ultrasound contrast agents. Proc Natl Acad Sci U S A. 2012;109:16612–7.CrossRef

Deng H, Xu Y, Liu Y, et al. Gold nanoparticles with asymmetric polymerase chain reaction for colorimetric detection of DNA sequence. Anal Chem. 2012;84:1253–8.CrossRef

Di Bucchianico S, Poma AM, Giardi MF, et al. Atomic force microscope nanolithography on chromosomes to generate single-cell genetic probes. J Nanobiotechnol. 2011;9:27.CrossRef

Du X, An H, Jin B, et al. Carbon nanotubes altering specificity of repeated PCR and DNA integrity properties. J Nanosci Nanotechnol. 2014;14:5547–51.CrossRef

Edwards KA, Wang Y, Baeumner AJ. Aptamer sandwich assays: human α-thrombin detection using liposome enhancement. Anal Bioanal Chem. 2010;398:2645–54.CrossRef

Esfandyarpour R, Yang L, Koochak Z, et al. Nanoelectronic three-dimensional (3D) nanotip sensing array for real-time, sensitive, label-free sequence specific detection of nucleic acids. Biomed Microdevices. 2016;18(1):7.CrossRef

Feng S, dos Santos MC, Carvalho BR, et al. Ultrasensitive molecular sensor using N-doped graphene through enhanced Raman scattering. Sci Adv. 2016;2(7):e1600322.CrossRef

Gaglia JL, Guimaraes AR, Harisinghani M, et al. Noninvasive imaging of pancreatic islet inflammation in type 1A diabetes patients. J Clin Invest. 2011;121:442–5.CrossRef

Gao N, Gao T, Yang X, et al. Specific detection of biomolecules in physiological solutions using graphene transistor biosensors. Proc Natl Acad Sci U S A. 2016;113:14633–8.CrossRef

Gaster RS, Hall DA, Nielsen CH, et al. Matrix-insensitive protein assays push the limits of biosensors in medicine. Nat Med. 2009;15:1327–32.CrossRef

Ghoroghchian PP, Therien MJ, Hammer DA. In vivo fluorescence imaging: a personal perspective. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2009;1:156–67.CrossRef

Golub E, Pelossof G, Freeman R, et al. Electrochemical, photoelectrochemical, and surface plasmon resonance detection of cocaine using supramolecular aptamer complexes and metallic or semiconductor nanoparticles. Anal Chem. 2009;81:9291–8.CrossRef

Goluch ED, Stoeva SI, Lee JS, et al. A microfluidic detection system based upon a surface immobilized biobarcode assay. Biosens Bioelectron. 2009;24:2397–403.CrossRef

Guzman R, Uchida N, Bliss TM, et al. Long-term monitoring of transplanted human neural stem cells in developmental and pathological contexts with MRI. Proc Natl Acad Sci U S A. 2007;104:10211–6.CrossRef

Han JH, Kim HJ, Sudheendra L, et al. Electrophoretic build-up of multi nanoparticle array for a highly sensitive immunoassay. Biosens Bioelectron. 2013;41:302–8.CrossRef

Haun JB, Yoon TJ, Lee H, Weissleder R. Magnetic nanoparticle biosensors. WIREs Nanomed Nanobiotechnol. 2010;2:291–304.CrossRef

He J, Evers DL, O’Leary TJ, Mason JT. Immunoliposome-PCR: a generic ultrasensitive quantitative antigen detection system. J Nanobiotechnol. 2012;10:26.CrossRef

Heath JR. Nanotechnologies for biomedical science and translational medicine. Proc Natl Acad Sci U S A. 2015;112:14436–43.CrossRef

Heller DA, Jin H, Martinez BM, et al. Multimodal optical sensing and analyte specificity using single-walled carbon nanotubes. Nat Nanotechnol. 2009;4:114–20.CrossRef

Jain KK. Nanodiagnostics: application of nanotechnology in molecular diagnostics. Expert Rev Mol Diagn. 2003;4:153–61.CrossRef

Jain KK. Applications of nanobiotechnology in clinical diagnostics. Clin Chem. 2007;53:2002–9.CrossRef

Jain KK. Handbook of biomarkers. New York: Springer; 2010.CrossRef

Jain KK. Molecular diagnostics: technologies, markets and companies. Basel: Jain PharmaBiotech Publications; 2017a.

Jain KK. Biochips & Microarrays. Technologies, markets and companies. Basel: Jain PharmaBiotech Publications; 2017b.

Jasmin, Torres AL, Nunes HM, et al. Optimized labeling of bone marrow mesenchymal cells with superparamagnetic iron oxide nanoparticles and in vivo visualization by magnetic resonance imaging. J Nanobiotechnology. 2011;9:4.CrossRef

Jo K, Dhingra DM, Odijk T, et al. A single-molecule barcoding system using nanoslits for DNA analysis. Proc Natl Acad Sci U S A. 2007;104:2673–8.CrossRef

John R, Rezaeipoor R, Adie SG, et al. In vivo magnetomotive optical molecular imaging using targeted magnetic nanoprobes. Proc Natl Acad Sci U S A. 2010;107:8085–90.CrossRef

Kaittanis C, Naser SA, Perez JM. One-step, nanoparticle-mediated bacterial detection with magnetic relaxation. Nano Lett. 2007;7:380–3.CrossRef

Kong J, Zhu J, Keyser UF. Single molecule based SNP detection using designed DNA carriers and solid-state nanopores. Chem Commun. 2017;53:436–9.CrossRef

Kosaka N, Mitsunaga M, Bhattacharyya S, et al. Self-illuminating in vivo lymphatic imaging using a bioluminescence resonance energy transfer quantum dot nano-particle. Contrast Media Mol Imaging. 2011;6:55–9.CrossRef

Kose AR, Koser H. Ferrofluid mediated nanocytometry. Lab Chip. 2012;12:190–6.CrossRef

Krishnamurthy V, Monfared SM, Cornell B. Ion-channel biosensors—part I: construction, operation, and clinical studies. IEEE Transactions Nanotechnol. 2010;9:303–12.CrossRef

le Masne de Chermont Q, Chaneac C, Seguin J, et al. Nanoprobes with near-infrared persistent luminescence for in vivo imaging. Proc Natl Acad Sci U S A. 2007;104:9266–71.CrossRef

Lee YE, Kopelman R. Nanoparticle PEBBLE sensors in live cells. Methods Enzymol. 2012;504:419–70.CrossRef

Loh OY, Ho AM, Rim JE, et al. Electric field-induced direct delivery of proteins by a nanofountain probe. Proc Natl Acad Sci U S A. 2008;105:16438–43.CrossRef

Lu N, Gao A, Dai P, et al. CMOS-compatible silicon nanowire field-effect transistors for ultrasensitive and label-free microRNAs sensing. Small. 2014;10:2022–8.CrossRef

Malashikhina N, Pavlov V. DNA-decorated nanoparticles as nanosensors for rapid detection of ascorbic acid. Biosens Bioelectron. 2012;33:241–6.CrossRef

McDonagh C, Stranik O, Nooney R, Maccraith BD. Nanoparticle strategies for enhancing the sensitivity of fluorescence-based biochips. Nanomedicine. 2009;4:645–56.CrossRef

Na HB, Lee JH, An K, et al. Development of a T1 contrast agent for magnetic resonance imaging using MnO nanoparticles. Angew Chem Int Ed Engl. 2007;46:5397–401.CrossRef

Nam JM, Stoeva SI, Mirkin CA. Bio-bar-code-based DNA detection with PCR-like sensitivity. J Am Chem Soc. 2004;126:5932–3.CrossRef

Nune SK, Gunda P, Thallapally PK, et al. Nanoparticles for biomedical imaging. Expert Opin Drug Deliv. 2009;6:1175–94.CrossRef

Partlow KC, Chen J, Brant JA, et al. 19F magnetic resonance imaging for stem/progenitor cell tracking with multiple unique perfluorocarbon nanobeacons. FASEB J. 2007;21:1647–54.CrossRef

Qu Q, Zhu Z, Wang Y, et al. Rapid and quantitative detection of Brucella by up-converting phosphor technology-based lateral-flow assay. J Microbiol Methods. 2009;79:121–3.CrossRef

Ravizzini G, Turkbey B, Barrett T, et al. Nanoparticles in sentinel lymph node mapping. WIREs Nanomed Nanobiotechnol. 2009;1:610–23.CrossRef

Shen MY, Li BR, Li YK. Silicon nanowire field-effect-transistor based biosensors: from sensitive to ultra-sensitive. Biosens Bioelectron. 2014;60:101–11.CrossRef

Shilo M, Reuveni T, Motiei M, Popovtzer R. Nanoparticles as computed tomography contrast agents: current status and future perspectives. Nanomedicine. 2012;7:257–69.CrossRef

Swanson SD, Kukowska-Latallo JF, Patri AK, et al. Targeted gadolinium-loaded dendrimer nanoparticles for tumor-specific magnetic resonance contrast enhancement. Int J Nanomedicine. 2008;3:201–10.CrossRef

Tisch U, Schlesinger I, Ionescu R, et al. Detection of Alzheimer’s and Parkinson’s disease from exhaled breath using nanomaterial-based sensors. Nanomedicine. 2013;8:43–56.CrossRef

Verellen N, Sonnefraud Y, Sobhani H, et al. Fano resonances in individual coherent plasmonic nanocavities. Nano Lett. 2009;9:1663–7.CrossRef

Vo-Dinh T, Zhang Y. Single-cell monitoring using fiberoptic nanosensors. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2011;3:79–85.CrossRef

Wang X, Hofmann O, Das R, et al. Integrated thin-film polymer/fullerene photodetectors for on-chip microfluidic chemiluminescence detection. Lab Chip. 2007;7:58–63.CrossRef

Wang X, Lou X, Wang Y, et al. QDs-DNA nanosensor for the detection of hepatitis B virus DNA and the single-base mutants. Biosens Bioelectron. 2010a;25:1934–40.CrossRef

Williams RM, Nayeem S, Dolash BD, Sooter LJ. The effect of DNA-dispersed single-walled carbon nanotubes on the polymerase chain reaction. PLoS One. 2014;9(4):e94117.CrossRef

Xing Y, Chaudry Q, Shen C, et al. Bioconjugated quantum dots for multiplexed and quantitative immunohistochemistry. Nat Protoc. 2007;2:1152–65.CrossRef

Yang B, Zhou G, Huang LL. PCR-free MDR1 polymorphism identification by gold nanoparticle probes. Anal Bioanal Chem. 2010;397:1937–45.CrossRef

Ymeti A, Greve J, Lambeck PV, et al. Fast, ultrasensitive virus detection using a young interferometer sensor. Nano Lett. 2007;7:394–7.CrossRef

Yu JS, Lim MC, Huynh DT, et al. Identifying the location of a single protein along the DNA strand using solid-state nanopores. ACS Nano. 2015;9:5289–98.CrossRef

Yun J, Sonabend AM, Ulasov IV, et al. A novel adenoviral vector labeled with superparamagnetic iron oxide nanoparticles for real-time tracking of viral delivery. J Clin Neurosci. 2012;19:875–80.CrossRef

Titel: Nanomolecular Diagnostics
verfasst von: Kewal K. Jain
Verlag: Springer New York
Buch: The Handbook of Nanomedicine
Print ISBN: 978-1-4939-6965-4

Electronic ISBN: 978-1-4939-6966-1

Copyright-Jahr: 2017
DOI: https://doi.org/10.1007/978-1-4939-6966-1_4

Premium Partner

Marktübersichten

Die im Laufe eines Jahres in der „adhäsion“ veröffentlichten Marktübersichten helfen Anwendern verschiedenster Branchen, sich einen gezielten Überblick über Lieferantenangebote zu verschaffen.

Zur Marktübersicht