Skip to main content

2017 | OriginalPaper | Buchkapitel

Nanoparticles: Applications, Toxicology and Safety Aspects

verfasst von : Anupam Dhasmana, Sumbul Firdaus, Krishna Pal Singh, Sana Raza, Qazi Mohammad Sajid Jamal, Kavindra Kumar Kesari, Qamar Rahman, Mohtashim Lohani

Erschienen in: Perspectives in Environmental Toxicology

Verlag: Springer International Publishing

Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.

search-config
loading …

Abstract

Nanotechnology has a global socioeconomic significance. On the brighter side, Nanoparticles (NPs) offer extraordinary technical competencies which allow them to perform enormously novel developments in science and industries. Whereas, on the darker side, just the same novel qualities of nanoparticles can concurrently evoke undesired features, which sometimes lead to adverse and harmful interactions with exposed organisms. Workers involved in manufacturing and handling of NPs in all countries face new hazards from these nanomaterials. The occupational safety and health associations have taken schemes to spot the gaps between awareness and practices. These international agencies formulate the guidelines for handling nano materials and fix their occupational exposure limits. In this chapter authors discussed the source and role of NPs in different areas, NPs induced toxicity, their interaction with different biomolecules, as well as the safety and handling guidelines of NPs in occupational and laboratory areas.

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 390 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Maschinenbau + Werkstoffe




 

Jetzt Wissensvorsprung sichern!

Literatur
Zurück zum Zitat Aguilera-Granja F, Dorantes-Dávila J, Morán-López JL (1993) Electronic structure of some semiconductor fullerenes. Nanostrc Mat 3:469–477 CrossRef Aguilera-Granja F, Dorantes-Dávila J, Morán-López JL (1993) Electronic structure of some semiconductor fullerenes. Nanostrc Mat 3:469–477 CrossRef
Zurück zum Zitat Aitken RJ, Creely KS, Tran CL (2004) Nanoparticles: An Occupational Hygiene Review. Research Report 274. Prepared by the Institute of Occupational Medicine for the Health and Safety Executive, North Riccarton, Edinburgh, England Aitken RJ, Creely KS, Tran CL (2004) Nanoparticles: An Occupational Hygiene Review. Research Report 274. Prepared by the Institute of Occupational Medicine for the Health and Safety Executive, North Riccarton, Edinburgh, England
Zurück zum Zitat Alexandra G, Juliane F, Bhattacharya K (2010) Nanoparticles induce changes of the electrical activity of neuronal networks on microelectrode array neurochips. Environ Health Perspect 118:1363–1369CrossRef Alexandra G, Juliane F, Bhattacharya K (2010) Nanoparticles induce changes of the electrical activity of neuronal networks on microelectrode array neurochips. Environ Health Perspect 118:1363–1369CrossRef
Zurück zum Zitat Alivisatos AP, Gu WW, Larabell C (2005) Quantum dots as cellular probes. Annu Rev Biomed Eng 7:55–76CrossRef Alivisatos AP, Gu WW, Larabell C (2005) Quantum dots as cellular probes. Annu Rev Biomed Eng 7:55–76CrossRef
Zurück zum Zitat Barlow PG, Donaldson K, MacCallum J (2005) Serum exposed to nanoparticle carbon black displays increased potential to induce macrophage migration. Toxicol Lett 155:397–401CrossRef Barlow PG, Donaldson K, MacCallum J (2005) Serum exposed to nanoparticle carbon black displays increased potential to induce macrophage migration. Toxicol Lett 155:397–401CrossRef
Zurück zum Zitat Barth JV, Costantini G, Kern K (2005) Engineering atomic and molecular nanostructures at surfaces. Nature 437:671–679CrossRef Barth JV, Costantini G, Kern K (2005) Engineering atomic and molecular nanostructures at surfaces. Nature 437:671–679CrossRef
Zurück zum Zitat Belgorodsky B, Fadeev L, Kolsenik J, Gozin M (2006) Formation of a soluble stable complex between pristine C60-fullerene and a native blood protein. ChemBioChem 7:1783–1789CrossRef Belgorodsky B, Fadeev L, Kolsenik J, Gozin M (2006) Formation of a soluble stable complex between pristine C60-fullerene and a native blood protein. ChemBioChem 7:1783–1789CrossRef
Zurück zum Zitat Benyamini H, Shulman Peleg A, Wolfson HJ (2006) Interaction of C60-fullerene and carboxyfullerene with proteins: docking and binding site alignment. Bioconjug Chem 17:378–386 Benyamini H, Shulman Peleg A, Wolfson HJ (2006) Interaction of C60-fullerene and carboxyfullerene with proteins: docking and binding site alignment. Bioconjug Chem 17:378–386
Zurück zum Zitat Bernholc J, Brenner D, Buongiorno NM (2002) Mechanical and electrical properties of nanotubes. Annu Rev Mater Res 32:347–375CrossRef Bernholc J, Brenner D, Buongiorno NM (2002) Mechanical and electrical properties of nanotubes. Annu Rev Mater Res 32:347–375CrossRef
Zurück zum Zitat Bosi S, Feruglio L, DaRos T (2004) Hemolytic effects of water-soluble fullerene derivatives. J Med Chem 47:6711–6715CrossRef Bosi S, Feruglio L, DaRos T (2004) Hemolytic effects of water-soluble fullerene derivatives. J Med Chem 47:6711–6715CrossRef
Zurück zum Zitat Brown DM, Wilson MR, MacNee W (2001) Size-dependent proinflammatory effects of ultrafine polystyrene particles: a role for surface area and oxidative stress in the enhanced activity of ultrafines. Toxicol App Pharmacol 175:191–199 Brown DM, Wilson MR, MacNee W (2001) Size-dependent proinflammatory effects of ultrafine polystyrene particles: a role for surface area and oxidative stress in the enhanced activity of ultrafines. Toxicol App Pharmacol 175:191–199
Zurück zum Zitat Brunner TJ, Wick P, Manser P (2006) In vitro cytotoxicity of oxide nanoparticles: comparison to asbestos, silica, and the effect of particle solubility. Environ Sci Technol 40:4374–4381CrossRef Brunner TJ, Wick P, Manser P (2006) In vitro cytotoxicity of oxide nanoparticles: comparison to asbestos, silica, and the effect of particle solubility. Environ Sci Technol 40:4374–4381CrossRef
Zurück zum Zitat Burcham P (2010) Nanotoxicology: a primer for chemists chemistry in Australia. R Aust Chem Inst Inc, Australia, pp 18–22 Burcham P (2010) Nanotoxicology: a primer for chemists chemistry in Australia. R Aust Chem Inst Inc, Australia, pp 18–22
Zurück zum Zitat Buxton DB, Lee SC, Wickline SA, Ferrari M (2003) Recommendations of the National Heart, Lung, and Blood Institute Nanotechnology Working Group. Circulation 108:2737–2742 CrossRef Buxton DB, Lee SC, Wickline SA, Ferrari M (2003) Recommendations of the National Heart, Lung, and Blood Institute Nanotechnology Working Group. Circulation 108:2737–2742 CrossRef
Zurück zum Zitat CDC / NIOSH (2009) Approaches to Safe Nanotechnology Managing the Health and Safety Concerns Associated with Engineered Nanomaterials, Department of Health & Human Service CDC / NIOSH (2009) Approaches to Safe Nanotechnology Managing the Health and Safety Concerns Associated with Engineered Nanomaterials,  Department of Health & Human Service
Zurück zum Zitat Chen HH, Yu C, Ueng TH (1998) Acute and subacute toxicity study of water-soluble polyalkylsulfonated C60 in rats. Toxicol Pathol 26:143–151CrossRef Chen HH, Yu C, Ueng TH (1998) Acute and subacute toxicity study of water-soluble polyalkylsulfonated C60 in rats. Toxicol Pathol 26:143–151CrossRef
Zurück zum Zitat Christof M, Niemeyer P (2001) Nanoparticles, proteins, and nucleic acids: biotechnology meets materials science. Angewandte Chemie-Int Ed 40:4128–4158CrossRef Christof M, Niemeyer P (2001) Nanoparticles, proteins, and nucleic acids: biotechnology meets materials science. Angewandte Chemie-Int Ed 40:4128–4158CrossRef
Zurück zum Zitat Curtis A, Wilkinson C (2001) Nanotechniques and approaches in biotechnology. Trends Biotechnol 19:97–101CrossRef Curtis A, Wilkinson C (2001) Nanotechniques and approaches in biotechnology. Trends Biotechnol 19:97–101CrossRef
Zurück zum Zitat Donaldson K, Stone V, Tran W (2004) Nanotoxicology. Occup Environ Med 61:727–728CrossRef Donaldson K, Stone V, Tran W (2004) Nanotoxicology. Occup Environ Med 61:727–728CrossRef
Zurück zum Zitat Donaldson K, Aitken R, Tran L (2006) Carbon nanotubes: a review of their properties in relation to pulmonary toxicology and workplace safety. Toxicol Sci 92:5–22CrossRef Donaldson K, Aitken R, Tran L (2006) Carbon nanotubes: a review of their properties in relation to pulmonary toxicology and workplace safety. Toxicol Sci 92:5–22CrossRef
Zurück zum Zitat Dreher LK (2005) Health and environmental impact of nanotechnology: toxicological assessment of manufactured nanoparticles. Toxicol Sci 77:3–5CrossRef Dreher LK (2005) Health and environmental impact of nanotechnology: toxicological assessment of manufactured nanoparticles. Toxicol Sci 77:3–5CrossRef
Zurück zum Zitat Duffin R, Tran CL, Clouter A (2002) The importance of surface area and specific reactivity in the acute pulmonary inflammatory response to particles. Ann Occup Hyg 46:242–245 Duffin R, Tran CL, Clouter A (2002) The importance of surface area and specific reactivity in the acute pulmonary inflammatory response to particles. Ann Occup Hyg 46:242–245
Zurück zum Zitat Duffin R, Tran L, Brown D (2007) Proinflammogenic effects of low-toxicity and metal nanoparticles in vivo and in vitro: highlighting the role of particle surface area and surface reactivity. Inhal Toxicol 19:849–856CrossRef Duffin R, Tran L, Brown D (2007) Proinflammogenic effects of low-toxicity and metal nanoparticles in vivo and in vitro: highlighting the role of particle surface area and surface reactivity. Inhal Toxicol 19:849–856CrossRef
Zurück zum Zitat Feder JB (2004) Health concerns in nanotechnology. The New York Times Feder JB (2004) Health concerns in nanotechnology. The New York Times
Zurück zum Zitat Feris K, Otto C, Tinker J (2010) Electrostatic interactions affect nanoparticle-mediated toxicity to gram-negative bacterium Pseudomonas aeruginosa PAO1. Langmuir 26:4429–4436 Feris K, Otto C, Tinker J (2010) Electrostatic interactions affect nanoparticle-mediated toxicity to gram-negative bacterium Pseudomonas aeruginosa PAO1. Langmuir 26:4429–4436
Zurück zum Zitat Fischer HC, Chan WCW (2007) Nanotoxicity: the growing need for in vivo study. Curr Opin Biotechnol 18:565–571CrossRef Fischer HC, Chan WCW (2007) Nanotoxicity: the growing need for in vivo study. Curr Opin Biotechnol 18:565–571CrossRef
Zurück zum Zitat Gao H, Kong Y (2004) Simulation of DNA-nanotube interactions. Ann Rev Mater Res 34:123–150CrossRef Gao H, Kong Y (2004) Simulation of DNA-nanotube interactions. Ann Rev Mater Res 34:123–150CrossRef
Zurück zum Zitat Gharbi N, Pressac M, Hadchouel M, Szware H, Wilson SR, Mousa F (2005) Fullerene is a powerful antioxident in vivo with no acute or subacute toxicity. Nano Lett, pp 2578–2585 Gharbi N, Pressac M, Hadchouel M, Szware H, Wilson SR, Mousa F (2005) Fullerene is a powerful antioxident in vivo with no acute or subacute toxicity. Nano Lett, pp 2578–2585
Zurück zum Zitat Gehrke I, Andreas G, Somborn-Schulz A (2015) Innovations in nanotechnology for water treatment. Nanotechnol Sci Appl 8:1–17CrossRef Gehrke I, Andreas G, Somborn-Schulz A (2015) Innovations in nanotechnology for water treatment. Nanotechnol Sci Appl 8:1–17CrossRef
Zurück zum Zitat Gu FX, Karnik R, Wang AZ (2007) Targeted nanoparticles for cancer therapy. Nano Today 2:14–21CrossRef Gu FX, Karnik R, Wang AZ (2007) Targeted nanoparticles for cancer therapy. Nano Today 2:14–21CrossRef
Zurück zum Zitat Gunasekera UA, Pankhurst QA, Douek M (2009) Imaging applications of nanotechnology in cancer. Target Oncol 4:169–181CrossRef Gunasekera UA, Pankhurst QA, Douek M (2009) Imaging applications of nanotechnology in cancer. Target Oncol 4:169–181CrossRef
Zurück zum Zitat Hanley C, Layne J, Punnoose A (2008) Preferential killing of cancer cells and activated human T cells using ZnO nanoparticles. Nanotechnology 19:295103CrossRef Hanley C, Layne J, Punnoose A (2008) Preferential killing of cancer cells and activated human T cells using ZnO nanoparticles. Nanotechnology 19:295103CrossRef
Zurück zum Zitat Hett A (2004) Nanotechnology: Small matter, many unknowns. Risk Perception. Zurich, Switzerland: Swiss Re. Hett A (2004) Nanotechnology: Small matter, many unknowns. Risk Perception. Zurich, Switzerland: Swiss Re.
Zurück zum Zitat Houili H, Tutis E, Izquierdo R (2010) Modeling nanoparticle embedde organic memory devices. Org Electron 11:514–520CrossRef  Houili H, Tutis E, Izquierdo R (2010) Modeling nanoparticle embedde organic memory devices. Org Electron 11:514–520CrossRef
Zurück zum Zitat Iijima S (1991) Helical microtubules of graphitic carbon. Nature 354:56–58CrossRef Iijima S (1991) Helical microtubules of graphitic carbon. Nature 354:56–58CrossRef
Zurück zum Zitat Jensen AW, Wilson SR, Schuster DI (1996) Biological applications of fullerenes. Bioorg Med Chem 4:767–779CrossRef Jensen AW, Wilson SR, Schuster DI (1996) Biological applications of fullerenes. Bioorg Med Chem 4:767–779CrossRef
Zurück zum Zitat Jia G, Wang HF, Yan L (2004) Cytotoxicity of carbon nanomaterials: single-wall nanotube, multi-wall nanotube, and fullerene. Environ Sci Technol 39:1378–1383CrossRef Jia G, Wang HF, Yan L (2004) Cytotoxicity of carbon nanomaterials: single-wall nanotube, multi-wall nanotube, and fullerene. Environ Sci Technol 39:1378–1383CrossRef
Zurück zum Zitat Jin P, Chen Y, Zhang SB, Chen Z (2005) Interations between Al12X nanoparticles & DNA nucleobases/base pairs: implications for nanotoxicity. J Mol Model, pp 559–568 Jin P, Chen Y, Zhang SB, Chen Z (2005) Interations between Al12X nanoparticles & DNA nucleobases/base pairs: implications for nanotoxicity. J Mol Model, pp 559–568
Zurück zum Zitat Krusic PJ, Waserman E, Keizer PN (1991) Radical reaction of C60. Science 254:1183–1185CrossRef Krusic PJ, Waserman E, Keizer PN (1991) Radical reaction of C60. Science 254:1183–1185CrossRef
Zurück zum Zitat Kuzmany H, Winter J, Burger B (1997) Polymeric fullerenes. Synth Met 85:1173–1177 CrossRef Kuzmany H, Winter J, Burger B (1997) Polymeric fullerenes. Synth Met 85:1173–1177 CrossRef
Zurück zum Zitat Lam CW, James JT, McCluskey R, Hunter RL (2004) Plumonary toxicity of Single Walled Carbon Nanotubes in mice 7 & 90 days after intratrachial instillation. Toxicol Sci, pp 126–134 Lam CW, James JT, McCluskey R, Hunter RL (2004) Plumonary toxicity of Single Walled Carbon Nanotubes in mice 7 & 90 days after intratrachial instillation. Toxicol Sci, pp 126–134
Zurück zum Zitat Lin YW, Liu CW, Chang HT (2009) DNA functionalized gold nanoparticles for bioanalysis. Anal Methods 1:14–24CrossRef Lin YW, Liu CW, Chang HT (2009) DNA functionalized gold nanoparticles for bioanalysis. Anal Methods 1:14–24CrossRef
Zurück zum Zitat Luther W (2004) Technological analysis: industrial application of nanomaterials chances and risks. Future Technologies Division of VDI Technologiezentrum GmbH, Germany, pp 1–119 Luther W (2004) Technological analysis: industrial application of nanomaterials chances and risks. Future Technologies Division of VDI Technologiezentrum GmbH, Germany, pp 1–119
Zurück zum Zitat McBain SC, Yiu HHP, Dobson J (2008) Magnetic nanoparticles for gene and drug delivery. Int J Nanomedicine 3:169–180 McBain SC, Yiu HHP, Dobson J (2008) Magnetic nanoparticles for gene and drug delivery. Int J Nanomedicine 3:169–180
Zurück zum Zitat Medina C, Santos-Martinez MJ, Radomski A (2007) Nanoparticles: pharmacological and toxicological significance. Br J Pharmacol 150:552–558CrossRef Medina C, Santos-Martinez MJ, Radomski A (2007) Nanoparticles: pharmacological and toxicological significance. Br J Pharmacol 150:552–558CrossRef
Zurück zum Zitat Mori T, Takada H, Ito S (2006) Preclinical studies on safety of fullerene upon acute oral administration and evaluation for no mutagenesis. Toxicology 225:48–54CrossRef Mori T, Takada H, Ito S (2006) Preclinical studies on safety of fullerene upon acute oral administration and evaluation for no mutagenesis. Toxicology 225:48–54CrossRef
Zurück zum Zitat Nacsa J, Segesdi J, Gyiiris A (1997) Antiretroviral effects of nonderivatized C60 in vitro, fullerenes. Nanotub Carbon Nanostr 5:969–976 Nacsa J, Segesdi J, Gyiiris A (1997) Antiretroviral effects of nonderivatized C60 in vitro, fullerenes. Nanotub Carbon Nanostr 5:969–976
Zurück zum Zitat Nel A, Xia T, Madler L, Li N (2006) Toxic potential of materials at the nanolevel. Science 311:622–627CrossRef Nel A, Xia T, Madler L, Li N (2006) Toxic potential of materials at the nanolevel. Science 311:622–627CrossRef
Zurück zum Zitat Nelson MA, Domann F, Bowden GT (1993) Acute and subchronic exposure of topically applied fullerene extracts on the mouse skin. Toxicol Ind Health 9:623–630 Nelson MA, Domann F, Bowden GT (1993) Acute and subchronic exposure of topically applied fullerene extracts on the mouse skin. Toxicol Ind Health 9:623–630
Zurück zum Zitat Noon WH, Kong Y, Ma J (2002) Molecular dynamics analysis of a buckyball–antibody complex. Proc Natl Acad Sci USA 2:6466–6470CrossRef Noon WH, Kong Y, Ma J (2002) Molecular dynamics analysis of a buckyball–antibody complex. Proc Natl Acad Sci USA 2:6466–6470CrossRef
Zurück zum Zitat Oberdörster G, Ferin J, Gelein R (1992) Role of the alveolar macrophage in lung injury studies with ultrafine particles. Environ Health Perspect 97:193–199CrossRef Oberdörster G, Ferin J, Gelein R (1992) Role of the alveolar macrophage in lung injury studies with ultrafine particles. Environ Health Perspect 97:193–199CrossRef
Zurück zum Zitat Oberdörster G, Ferin J, Lehnert BE (1994a) Cor-relation between particle-size, in-vivo particle per-sistence, and lung injury. Environ Health Perspect 102:173–179CrossRef Oberdörster G, Ferin J, Lehnert BE (1994a) Cor-relation between particle-size, in-vivo particle per-sistence, and lung injury. Environ Health Perspect 102:173–179CrossRef
Zurück zum Zitat Oberdörster G, Ferin J, Soderholm S (1994b) Increased pul-monary toxicity of inhaled ultrafine particles: due to lung overload alone. Ann OccupHyg 38:295–302 Oberdörster G, Ferin J, Soderholm S (1994b) Increased pul-monary toxicity of inhaled ultrafine particles: due to lung overload alone. Ann OccupHyg 38:295–302
Zurück zum Zitat Oberdörster G, Sharp Z, Atudorei V (2002) Extrapulmonary translocation of ultrafine carbon particles following whole-body inhalation exposure of rats. J Toxicol Environ Health 65:1531–1543CrossRef Oberdörster G, Sharp Z, Atudorei V (2002) Extrapulmonary translocation of ultrafine carbon particles following whole-body inhalation exposure of rats. J Toxicol Environ Health 65:1531–1543CrossRef
Zurück zum Zitat Oberdörster G, Oberdörster E, Oberdörster J (2005) Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect 113:823–839CrossRef Oberdörster G, Oberdörster E, Oberdörster J (2005) Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect 113:823–839CrossRef
Zurück zum Zitat Osawa E (1970) Super-aromatic compounds. Kagaku 25:854–863 Osawa E (1970) Super-aromatic compounds. Kagaku 25:854–863
Zurück zum Zitat Panessa-Warren B, Warren J, Wong SS, Misewich JA (2006) Biological cellular response to carbon nanoparticle toxicity. J Phy: Condensed Matter 18:2185–2201 Panessa-Warren B, Warren J, Wong SS, Misewich JA (2006) Biological cellular response to carbon nanoparticle toxicity. J Phy: Condensed Matter 18:2185–2201
Zurück zum Zitat Papp T, Schiffmann D, Weiss D (2008) Human health implications of nanomaterial exposure. Nanotoxicology 2:9–27CrossRef Papp T, Schiffmann D, Weiss D (2008) Human health implications of nanomaterial exposure. Nanotoxicology 2:9–27CrossRef
Zurück zum Zitat Peters A, Pope A (2002) Cardiopulmonary mortality and air pollution. Lancet 360:1184–1185CrossRef Peters A, Pope A (2002) Cardiopulmonary mortality and air pollution. Lancet 360:1184–1185CrossRef
Zurück zum Zitat Pope CA (2001) Particulate air pollution, C-reactive protein and cardiac risk. Eur Heart J 22:1149–1150CrossRef Pope CA (2001) Particulate air pollution, C-reactive protein and cardiac risk. Eur Heart J 22:1149–1150CrossRef
Zurück zum Zitat Poulsen SS, Saber AT, Williams A (2015) MWCNTs of different physicochemical properties cause similar inflammatory responses, but differences in transcriptional and histological markers of fibrosis in mouse lungs. Toxicol Appl Pharmacol 284:16–32CrossRef Poulsen SS, Saber AT, Williams A (2015) MWCNTs of different physicochemical properties cause similar inflammatory responses, but differences in transcriptional and histological markers of fibrosis in mouse lungs. Toxicol Appl Pharmacol 284:16–32CrossRef
Zurück zum Zitat Powell CM, Kanarek SM (2006) Nanomaterial health effects—part one, background and current knowledge. Wisconsin Med J 105:16–20 Powell CM, Kanarek SM (2006) Nanomaterial health effects—part one, background and current knowledge. Wisconsin Med J 105:16–20
Zurück zum Zitat Qiao R, Roberts AP, Mount AS (2007) Translocation of C60 and its derivatives across a lipid bilayer. Nano Lett 7:614–619CrossRef Qiao R, Roberts AP, Mount AS (2007) Translocation of C60 and its derivatives across a lipid bilayer. Nano Lett 7:614–619CrossRef
Zurück zum Zitat Ramón-Azcón J, Ahadian S, Obregón R (2014) Applications of carbon nanotubes in stem cell research. J Biomed Nanotechnol 10:2539–2561CrossRef Ramón-Azcón J, Ahadian S, Obregón R (2014) Applications of carbon nanotubes in stem cell research. J Biomed Nanotechnol 10:2539–2561CrossRef
Zurück zum Zitat Ryu JH, Colby TV, Hartman TE, Vassallo R (2001) Smoking-related interstitial lung diseases: a concise review. Eur Respir J 17:122–132CrossRef Ryu JH, Colby TV, Hartman TE, Vassallo R (2001) Smoking-related interstitial lung diseases: a concise review. Eur Respir J 17:122–132CrossRef
Zurück zum Zitat Sachlos E, Gotora D, Czernuszka JT (2006) Collagen scaffolds reinforced with biomimetic composite nano-sized carbonate-substituted hydroxyapatite crystals and shaped by rapid prototyping to contain internal microchannels. Tissue Eng 12:2479–2487CrossRef Sachlos E, Gotora D, Czernuszka JT (2006) Collagen scaffolds reinforced with biomimetic composite nano-sized carbonate-substituted hydroxyapatite crystals and shaped by rapid prototyping to contain internal microchannels. Tissue Eng 12:2479–2487CrossRef
Zurück zum Zitat Salata OV (2004) Applications of nanoparticles in biology and medicine. J Nanobiotechnol 2:2–6CrossRef Salata OV (2004) Applications of nanoparticles in biology and medicine. J Nanobiotechnol 2:2–6CrossRef
Zurück zum Zitat Schulte PA, Salamanca BF (2007) Ethical and scientific issues of Nanotechnology in the workplace. Environ Health Perspect 115:5–12CrossRef Schulte PA, Salamanca BF (2007) Ethical and scientific issues of Nanotechnology in the workplace. Environ Health Perspect 115:5–12CrossRef
Zurück zum Zitat Shen JW, Wu T, Wang Q, Kang Y (2008) Induced stepwise conformational change of human serum albumin on carbon nanotube surfaces. Biomaterials 29(28):3847–3855 Shen JW, Wu T, Wang Q, Kang Y (2008) Induced stepwise conformational change of human serum albumin on carbon nanotube surfaces. Biomaterials 29(28):3847–3855
Zurück zum Zitat Shipelin VA, Smirnova TA, Gmoshinskii IV, Tutelyan VA (2015) Analysis of toxicity biomarkers of fullerene C60 nanoparticles by confocal fluorescent microscopy. Bull Exp Biol Med 158:443–449CrossRef Shipelin VA, Smirnova TA, Gmoshinskii IV, Tutelyan VA (2015) Analysis of toxicity biomarkers of fullerene C60 nanoparticles by confocal fluorescent microscopy. Bull Exp Biol Med 158:443–449CrossRef
Zurück zum Zitat Smalley RE, Yakobson BI (1998) The future of the fullerenes. Solid State Commun 107:597–606CrossRef Smalley RE, Yakobson BI (1998) The future of the fullerenes. Solid State Commun 107:597–606CrossRef
Zurück zum Zitat Spence JCH (1999) The future of atomic resolution electron microscopy for materials science. Mater Sci Eng 26:1–49CrossRef Spence JCH (1999) The future of atomic resolution electron microscopy for materials science. Mater Sci Eng 26:1–49CrossRef
Zurück zum Zitat Terzano C, Di Stefano F, Conti V (2010) Air pollution ultrafine particles: toxicity beyond the lung. Eur Rev Med Pharmacol Sci 14:809–821 Terzano C, Di Stefano F, Conti V (2010) Air pollution ultrafine particles: toxicity beyond the lung. Eur Rev Med Pharmacol Sci 14:809–821
Zurück zum Zitat Tomalia AD (2004) Birth of new macromolecular architecture: dendrimers as quantized building blocks for nanoscale synthetic organic chemistry. Aldrichimica Acta 37:39–57 Tomalia AD (2004) Birth of new macromolecular architecture: dendrimers as quantized building blocks for nanoscale synthetic organic chemistry. Aldrichimica Acta 37:39–57
Zurück zum Zitat Tran C, Buchanan LD, Cullen RT (2000) Inhalation of poorly soluble particles. II. Influence of particle surface area on inflammation and clearance. Inhal Toxicol 12:1113–1126CrossRef Tran C, Buchanan LD, Cullen RT (2000) Inhalation of poorly soluble particles. II. Influence of particle surface area on inflammation and clearance. Inhal Toxicol 12:1113–1126CrossRef
Zurück zum Zitat Tsao N, Kanakamma P, Luh TY (1999) Inhibition of escherichia coli-induced meningites by carboxyfullerene. Antimicrob Agents Chemother 43:2273–2277 Tsao N, Kanakamma P, Luh TY (1999) Inhibition of escherichia coli-induced meningites by carboxyfullerene. Antimicrob Agents Chemother 43:2273–2277
Zurück zum Zitat Vaseashta A, Dimova-Malinovska D (2005) Nanostructured and nanoscale devices, sensors and detectors. Sci Technol Adv Mater 6:312–318CrossRef Vaseashta A, Dimova-Malinovska D (2005) Nanostructured and nanoscale devices, sensors and detectors. Sci Technol Adv Mater 6:312–318CrossRef
Zurück zum Zitat Waren CWC, Nie SM (1998) Quantum dot bioconjugatesfor ultrasensitive nonisotopicdetection. Science 281:2016–2018CrossRef Waren CWC, Nie SM (1998) Quantum dot bioconjugatesfor ultrasensitive nonisotopicdetection. Science 281:2016–2018CrossRef
Zurück zum Zitat Warheit DB, Laurence BR, Reed KL (2004) Comparative pulmonary toxicity assessment of single-wall carbonnanotubes in rats. Toxicol Sci 77:117–125CrossRef Warheit DB, Laurence BR, Reed KL (2004) Comparative pulmonary toxicity assessment of single-wall carbonnanotubes in rats. Toxicol Sci 77:117–125CrossRef
Zurück zum Zitat Wilson LJ, Cagle DW, Thrash TP (1999) Metallofullerene drug design. Coord Chem Rev 190:199–207CrossRef Wilson LJ, Cagle DW, Thrash TP (1999) Metallofullerene drug design. Coord Chem Rev 190:199–207CrossRef
Zurück zum Zitat Yamago S, Tokuyama H, Nakamura E (1995) In vivo biological behaviour of a water-miscible fullerene: 14C labelling, absorption, distribution, excretion and acute toxicity. Chem Biol 2:385–389CrossRef Yamago S, Tokuyama H, Nakamura E (1995) In vivo biological behaviour of a water-miscible fullerene: 14C labelling, absorption, distribution, excretion and acute toxicity. Chem Biol 2:385–389CrossRef
Zurück zum Zitat Yezhelyev VM, Gao X, Xing Y (2006) Emerging use of nanoparticles in diagnosis and treatment of breast cancer. Lancet 7:657–667CrossRef Yezhelyev VM, Gao X, Xing Y (2006) Emerging use of nanoparticles in diagnosis and treatment of breast cancer. Lancet 7:657–667CrossRef
Zurück zum Zitat Zhang Z, Shen C, Wang M (2008) An aqueous suspension of carbon nanopowder enhances the efficiency of a polymerase chain reaction. Nanotechnology 44:537–542 Zhang Z, Shen C, Wang M (2008) An aqueous suspension of carbon nanopowder enhances the efficiency of a polymerase chain reaction. Nanotechnology 44:537–542
Zurück zum Zitat Zhao X, Striolo AA, Cummings PT (2005) C60 binds to and deforms nucleotides. Biophys J 89:3856–3862CrossRef Zhao X, Striolo AA, Cummings PT (2005) C60 binds to and deforms nucleotides. Biophys J 89:3856–3862CrossRef
Zurück zum Zitat Zhao YL, Xing GM, Chai ZF (2008) Nanotoxicology: are carbontubes safe? Nat Nanotoxicol 3:191–192CrossRef Zhao YL, Xing GM, Chai ZF (2008) Nanotoxicology: are carbontubes safe? Nat Nanotoxicol 3:191–192CrossRef
Metadaten
Titel
Nanoparticles: Applications, Toxicology and Safety Aspects
verfasst von
Anupam Dhasmana
Sumbul Firdaus
Krishna Pal Singh
Sana Raza
Qazi Mohammad Sajid Jamal
Kavindra Kumar Kesari
Qamar Rahman
Mohtashim Lohani
Copyright-Jahr
2017
DOI
https://doi.org/10.1007/978-3-319-46248-6_3