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Erschienen in:
2007 | OriginalPaper | Buchkapitel
Nanotechnology and the Detection of Biomolecular Recognition Using Magnetoresistive Transducers
verfasst von : Paulo P. Freitas, Hugo A. Ferreira, Filipe Cardoso, Susana Cardoso, Ricardo Ferreira, Jose Almeida, Andre Guedes, Virginia Chu, João P. Conde, Verónica Martins, Luis Fonseca, Joaquim S. Cabral, José Germano, Leonel Sousa, Moisés Piedade, Bertinho Silva, José M. Lemos, Luka A. Clarke, Margarida D. Amaral
Erschienen in: A Portrait of State-of-the-Art Research at the Technical University of Lisbon
Verlag: Springer Netherlands
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An integrated electronic biochip platform for the detection of biomolecular recognition is described. It includes the detection module, where labeled target DNA/antibody molecules are magnetically arrayed towards immobilized probes (cDNA/antigen) and where DNA-cDNA hybridization or antibody-antigen interaction is detected. Magnetic nanobeads are used as labels for targets, and magnetic field sensors are used to detect beads presence. The present device holds 256 probe sites in a matrix containing one magnetic tunnel junction and one thin film PIN diode at each node. A microfluidics chamber and a credit card sized electronics board complete the microsystem. Diagnostic applications include the detection of cystic fibrosis relate gene mutations (DNA chip) and the detection of Salmonella and Es-cherichia coli presence in water (immunoassay).