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01.09.2021 | ORIGINAL PAPER

New complexes of metformin based on the copolymer of N-vinylpyrrolidone with triethylene glycol dimethacrylate and their activity in experimental type 2 diabetes mellitus

verfasst von: Svetlana V. Kurmaz, N. V. Fadeeva, Y. V. Soldatova, I. I. Faingold, D. A. Poletaeva, V. M. Ignat’ev, N. S. Emel’yanova, G. V. Shilov, R. A. Kotelnikova

Erschienen in: Journal of Polymer Research | Ausgabe 9/2021

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Abstract

The complexes of metformin (MET) and the copolymer of N-vinylpyrrolidone with triethylene glycol dimethacrylate with absolute molecular weight ca. 26 kDa and hydrodynamic radius of macromolecules about 4 nm have been prepared and studied in water buffer solution. Their sizes in neutral phosphate buffer solution depended on MET (10–40 wt%) per the copolymer content, temperature and the copolymer concentrations. Quantum chemical simulation has shown the most energetically favorable and stable structure is one with the coordination of neighboring NH₂ groups of MET via oxygen carbonyl of the VP fragment. The effective binding constant of MET with the copolymer estimated from the absorption spectroscopy was found to be ~ 1.8 × 10³ M⁻¹. The MET-copolymer compositions were analyzed by IR spectroscopy, thermogravimetry, differential scanning calorimetry, and X-ray diffraction. The copolymer complex with 20 wt% of MET affected blood glucose level in streptozotocin-induced diabetic mice like MET and decreased aldose reductase activity in contrast with the drug and MET-PVP complex.

Vorheriger Artikel Surface immobilization of PCL electrospun nanofibers with pexiganan for wound dressing

Nächster Artikel CO2 adsorption onto 1-butyl-3-vinylimidazolium based poly(ionic liquid)s: experimental and theoretical studies

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Titel: New complexes of metformin based on the copolymer of N-vinylpyrrolidone with triethylene glycol dimethacrylate and their activity in experimental type 2 diabetes mellitus
verfasst von: Svetlana V. Kurmaz
N. V. Fadeeva
Y. V. Soldatova
I. I. Faingold
D. A. Poletaeva
V. M. Ignat’ev
N. S. Emel’yanova
G. V. Shilov
R. A. Kotelnikova
Publikationsdatum: 01.09.2021
Verlag: Springer Netherlands
Erschienen in: Journal of Polymer Research / Ausgabe 9/2021
Print ISSN: 1022-9760
Elektronische ISSN: 1572-8935
DOI: https://doi.org/10.1007/s10965-021-02684-x

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