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Acta Mechanica Sinica
Erschienen in: Acta Mechanica Sinica 6/2016

14.10.2016 | Research Paper

On the gating of mechanosensitive channels by fluid shear stress

verfasst von: Zhangli Peng, On Shun Pak, Zhe Feng, Allen P. Liu, Yuan-Nan Young

Erschienen in: Acta Mechanica Sinica | Ausgabe 6/2016

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Abstract

Mechanosensation is an important process in biological fluid–structure interaction. To understand the biophysics underlying mechanosensation, it is essential to quantify the correlation between membrane deformation, membrane tension, external fluid shear stress, and conformation of mechanosensitive (MS) channels. Smoothed dissipative particle dynamics (SDPD) simulations of vesicle/cell in three types of flow configurations are conducted to calculate the tension in lipid membrane due to fluid shear stress from the surrounding viscous flow. In combination with a simple continuum model for an MS channel, SDPD simulation results suggest that shearing adhered vesicles/cells is more effective to induce membrane tension sufficient to stretch MS channels open than a free shear flow or a constrictive channel flow. In addition, we incorporate the bilayer–cytoskeletal interaction in a two-component model to probe the effects of a cytoskeletal network on the gating of MS channels.
Vorheriger Artikel Biomimetic flexible plate actuators are faster and more efficient with a passive attachment
Nächster Artikel An IB-LBM study of continuous cell sorting in deterministic lateral displacement arrays

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Metadaten
Titel
On the gating of mechanosensitive channels by fluid shear stress
verfasst von
Zhangli Peng
On Shun Pak
Zhe Feng
Allen P. Liu
Yuan-Nan Young
Publikationsdatum
14.10.2016
Verlag
The Chinese Society of Theoretical and Applied Mechanics; Institute of Mechanics, Chinese Academy of Sciences
Erschienen in
Acta Mechanica Sinica / Ausgabe 6/2016
Print ISSN: 0567-7718
Elektronische ISSN: 1614-3116
DOI
https://doi.org/10.1007/s10409-016-0606-y

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