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Erschienen in:
A Brief Introduction to Microfluidics Kapitel lesen Erstes Kapitel lesen

2016 | OriginalPaper | Buchkapitel

11. Organ on Chip

verfasst von : N. Beißner, T. Lorenz, S. Reichl

Erschienen in: Microsystems for Pharmatechnology

Verlag: Springer International Publishing

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Abstract

The process of new drug development is both time and cost intensive. Therefore, all test systems, in particular during the pre-clinical phase, have to provide reliable results to minimize the risk of failure at a later stage of drug development. However, current pre-clinical studies are mainly performed using experimental animals and in vitro cell culture models, which both are not able to reliably emulate human physiology. As a consequence, the common test procedures may be one reason for late-stage drug failures. Hence, improved test systems are needed, which mimic the diverse and dynamic human physiology and are well controllable and suitable for high-throughput screening.
High expectations have been raised by the development of organ on chip (OOC) systems. These novel microdevices combine the benefits of an engineered, physiological-like microenvironment with the advantages of well-characterized human cells. Furthermore, due to the small dimensions of OOCs, it is possible to work with small amounts of drugs, so OOCs are suitable for high-throughput screening. Moreover, OOCs can include biosensors that allow online measurements of the viability and functionality of the cells in real time. Additionally, OOCs containing tissues from different origins can be connected by microfluidic techniques to form multiple OOCs.
This chapter takes a closer look at the technical as well as the cellular aspects of OOC technology. Subsequently, the presentation of various already developed OOCs and promising future applications in pharmaceutical research and development shall underline the enormous potential of OOCs in the reduction of animal experiments and the precise emulation of human physiology.

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Vorheriges Kapitel Drug Delivery Through Microneedles
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Metadaten
Titel
Organ on Chip
verfasst von
N. Beißner
T. Lorenz
S. Reichl
Copyright-Jahr
2016
Buch
Microsystems for Pharmatechnology

Print ISBN: 978-3-319-26918-4

Electronic ISBN: 978-3-319-26920-7

Copyright-Jahr: 2016

DOI
https://doi.org/10.1007/978-3-319-26920-7_11

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