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Journal of Materials Science
Erschienen in: Journal of Materials Science 23/2020

14.05.2020 | Materials for life sciences

Poly (ε-caprolactone)/poly (N-vinyl-2-pyrrolidone) core–shell nanofibers loaded by multi-walled carbon nanotubes and 5-fluorouracil: an anticancer drug delivery system

verfasst von: Mina Nasari, Dariush Semnani, Mehdi Hadjianfar, Saeid Amanpour

Erschienen in: Journal of Materials Science | Ausgabe 23/2020

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Abstract

Cancer is one of the most fatal diseases in the world. Chemotherapy and radiation therapy are conventional cancer treatments affecting healthy tissues and also have many side effects. Drug delivery systems based on nanofibers can be used as cancer drug carrier with the least side effects. 5FU is one of the most common medicines for many types of cancer. In this study, PCL/PVP core–shell nanofibers containing MWCNTs were performed as 5FU carrier, which was loaded in core of these nanofibers. FESEM images showed all these core–shell nanofibers are uniform and the average diameter was 300–400 nm. There was no interaction between components of nanofibers, and the presence of 5FU in nanofibers was confirmed. The presence of MWCNTs loaded in shell improved the tensile properties. The degradability of nanofibers was investigated, and it was improved by increasing PVP in nanofibers. The morphology change in nanofibers was investigated by FESEM images after degradation. The release behavior of nanofibers was studied. These nanofibers had sustained and prolonged release, and the optimum sample in which 85% of drug released after 528 h was used for cytotoxicity test. The drug release mechanism was modeled by various mathematical models and followed Fick's law. MTT assay on HeLa cell line showed that cell cytotoxicity of 5FU loaded nanofibers was 50.35% after 72 h. The non-toxicity of carrier and efficacy of the drug loaded nanofibers mat on cervical cancer cell line were confirmed. This drug delivery system has the potential to perform as post-surgical anticancer drug delivery system.
Vorheriger Artikel Dual-emission fluorescent probe templated by spherical polyelectrolyte brush for ratiometric detection of copper ions
Nächster Artikel In vitro wear characteristics of a nano-hydroxyapatite filled dental resin composite under two-body wear condition

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Literatur
1.
Siegel RL, Miller KD, Jemal A (2020) Cancer statistics. CA Cancer J Clin 70(1):7–30CrossRef
2.
Lewandowska U, Gorlach S, Owczarek K, Hrabec E, Szewczyk K (2014) Synergistic interactions between anticancer chemotherapeutics and phenolic compounds and anticancer synergy between polyphenols. Adv Hyg Exp Med 68
3.
Zhang N, Yin Y, Xu SJ, Chen WS (2008) 5-Fluorouracil: mechanisms of resistance and reversal strategies. Molecules 13(8):1551–1569CrossRef
4.
Steichen SD, Caldorera-Moore M, Peppas NA (2013) A review of current nanoparticle and targeting moieties for the delivery of cancer therapeutics. Eur J Pharmaceut Sci 48(3):416–427CrossRef
5.
Prabaharan M (2015) Chitosan-based nanoparticles for tumor-targeted drug delivery. Int J Biol Macromol 72:1313–1322CrossRef
6.
Hu X, Liu S, Zhou G, Huang Y, Xie Z, Jing X (2014) Electrospinning of polymeric nanofibers for drug delivery applications. J Control Release 185:12–21CrossRef
7.
Grem JL (2000) 5-Fluorouracil: forty-plus and still ticking. A review of its preclinical and clinical development. Investig New Drugs 18(4):299–313CrossRef
8.
Rejinold NS, Muthunarayanan M, Chennazhi KP, Nair SV, Jayakumar R (2011) 5-Fluorouracil loaded fibrinogen nanoparticles for cancer drug delivery applications. Int J Biol Macromol 48(1):98–105CrossRef
9.
Okuda T, Tominaga K, Kidoaki S (2010) Time-programmed dual release formulation by multilayered drug-loaded nanofiber meshes. J Control Release 143(2):258–264CrossRef
10.
Ajnai G, Chiu A, Kan T, Cheng CC, Tsai TH, Chang J (2014) Trends of gold nanoparticle-based drug delivery system in cancer therapy. J Exp Clin Med 6(6):172–178CrossRef
11.
Hadjianfar M, Semnani D, Varshosaz J (2018) Polycaprolactone/chitosan blend nanofibers loaded by 5-fluorouracil: An approach to anticancer drug delivery system. Polym Adv Technol 29(12):2972–2981CrossRef
12.
Gao Y, Bai Y, Zhao D, Chang MW, Ahmad Z, Li JS (2015) Tuning microparticle porosity during single needle electrospraying synthesis via a non-solvent-based physicochemical approach. Polymers 7(12):2701–2710CrossRef
13.
Zamani M, Prabhakaran MP, Ramakrishna S (2013) Advances in drug delivery via electrospun and electrosprayed nanomaterials. Int J Nanomed 8:2997
14.
Torres-Martínez EJ, Cornejo Bravo JM, Serrano Medina A, Pérez González GL, Villarreal Gómez LJ (2018) A summary of electrospun nanofibers as drug delivery system: Drugs loaded and biopolymers used as matrices. Curr Drug Deliv 15(10):1360–1374CrossRef
15.
Zeng J, Yang L, Liang Q, Zhang X, Guan H, Xu X, Jing X (2005) Influence of the drug compatibility with polymer solution on the release kinetics of electrospun fiber formulation. J Control Release 105(1–2):43–51CrossRef
16.
Absar S, Khan M, Edwards K, Neumann J (2015) Investigation of synthesis and processing of cellulose, cellulose acetate and poly (ethylene oxide) nanofibers incorporating anti-cancer/tumor drug cis-diammineplatinum (II) dichloride using electrospinning techniques. J Polym Eng 35(9):867–878CrossRef
17.
Absar S, Khan M, Edwards K, Calamas D (2014) Electrospinning of cisplatin-loaded cellulose nanofibers for cancer drug delivery. In: ASME 2014 international mechanical engineering congress and exposition. American Society of Mechanical Engineers Digital Collection
18.
Martins AF, Vlcek J, Wigmosta T, Hedayati M, Reynolds MM, Popat KC, Kipper MJ (2020) Chitosan/iota-carrageenan and chitosan/pectin polyelectrolyte multilayer scaffolds with antiadhesive and bactericidal properties. Appl Surf Sci 502:144282CrossRef
19.
Baker SR, Banerjee S, Bonin K, Guthold M (2016) Determining the mechanical properties of electrospun poly-ε-caprolactone (PCL) nanofibers using AFM and a novel fiber anchoring technique. Mater Sci Eng C 59:203–212CrossRef
20.
Niiyama E, Uto K, Ebara M (2019) Electrospun PCL-PCL polyblend nanofibers with high-and low-molecular weight for controlled degradation. Chem Lett 48(7):623–626CrossRef
21.
Cheng Z, Teoh SH (2004) Surface modification of ultra thin poly (ε-caprolactone) films using acrylic acid and collagen. Biomaterials 25(11):1991–2001CrossRef
22.
Chong EJ, Phan TT, Lim IJ, Zhang YZ, Bay BH, Ramakrishna S, Lim CT (2007) Evaluation of electrospun PCL/gelatin nanofibrous scaffold for wound healing and layered dermal reconstitution. Acta Biomater 3(3):321–330CrossRef
23.
Vernosfaderani FR, Semnani D (2018) Manufacturing and optimization the nanofibres tissue of poly (N-vinyl-2-pyrrolidone)-poly (e-caprolactone) shell/poly (N-vinyl-2-pyrrolidone)-amphotericin b core for controlled drug release system. Fibers Polym 19(3):620–626CrossRef
24.
Kim GM, Le KHT, Giannitelli SM, Lee YJ, Rainer A, Trombetta M (2013) Electrospinning of PCL/PVP blends for tissue engineering scaffolds. J Mater Sci Mater Med 24(6):1425–1442CrossRef
25.
Cruz DMG, Coutinho DF, Mano JF, Ribelles JLG, Sanchez MS (2009) Physical interactions in macroporous scaffolds based on poly (ɛ-caprolactone)/chitosan semi-interpenetrating polymer networks. Polymer 50(9):2058–2064CrossRef
26.
Qian W, Yu DG, Li Y, Liao YZ, Wang X, Wang L (2014) Dual drug release electrospun core-shell nanofibers with tunable dose in the second phase. Int J Mol Sci 15(1):774–786CrossRef
27.
Saraf A, Baggett LS, Raphael RM, Kasper FK, Mikos AG (2010) Regulated non-viral gene delivery from coaxial electrospun fiber mesh scaffolds. J Controll Release 143(1):95–103CrossRef
28.
Lee CH, Hung KC, Hsieh MJ, Chang SH, Juang JH, Hsieh IC, Liu SJ (2020) Core-shell insulin-loaded nanofibrous scaffolds for repairing diabetic wounds. Nanomed Nanotechnol Biol Med 24:102123CrossRef
29.
Liao IC, Chen S, Liu JB, Leong KW (2009) Sustained viral gene delivery through core-shell fibers. J Controll Release 139(1):48–55CrossRef
30.
Sill TJ, von Recum HA (2008) Electrospinning: applications in drug delivery and tissue engineering. Biomaterials 29(13):1989–2006CrossRef
31.
Iqbal S, Rashid MH, Arbab AS, Khan M (2017) Encapsulation of anticancer drugs (5-fluorouracil and paclitaxel) into polycaprolactone (PCL) nanofibers and in vitro testing for sustained and targeted therapy. J Biomed Nanotechnol 13(4):355–366CrossRef
32.
Yu H, Yang P, Jia Y, Zhang Y, Ye Q, Zeng S (2016) Regulation of biphasic drug release behavior by graphene oxide in polyvinyl pyrrolidone/poly (ε-caprolactone) core/sheath nanofiber mats. Coll Surf B Biointerfaces 146:63–69CrossRef
33.
Zhu LF, Zheng Y, Fan J, Yao Y, Ahmad Z, Chang MW (2019) A novel core-shell nanofiber drug delivery system intended for the synergistic treatment of melanoma. European Journal of Pharmaceutical Sciences 137:105002CrossRef
34.
Kaviannasab E, Semnani D, Khorasani SN, Varshosaz J, Khalili S, Ghahreman F (2019) Core-shell nanofibers of poly (ε–caprolactone) and Polyvinylpyrrolidone for drug delivery system. Mater Res Exp 6(11):115015CrossRef
35.
Wang B, Chen X, Ahmad Z, Huang J, Chang MW (2019) 3D electrohydrodynamic printing of highly aligned dual-core graphene composite matrices. Carbon 153:285–297CrossRef
36.
Songsurang K, Praphairaksit N, Siraleartmukul K, Muangsin N (2011) Electrospray fabrication of doxorubicin-chitosan-tripolyphosphate nanoparticles for delivery of doxorubicin. Arch Pharm Res 34(4):583CrossRef
37.
Gao Y, Zhao D, Chang MW, Ahmad Z, Li X, Suo H, Li JS (2015) Morphology control of electrosprayed core–shell particles via collection media variation. Mater Lett 146:59–64CrossRef
38.
Moon SI, Jin F, Lee CJ, Tsutsumi S, Hyon SH (2005) Novel carbon nanotube/poly (l-lactic acid) nanocomposites; their modulus, thermal stability, and electrical conductivity. Macromol Symp Wiley, Weinheim 224(1):287–296CrossRef
39.
40.
Lamastra FR, Puglia D, Monti M, Vella A, Peponi L, Kenny JM, Nanni F (2012) Poly (ε-caprolactone) reinforced with fibres of poly (methyl methacrylate) loaded with multiwall carbon nanotubes or graphene nanoplatelets. Chem Eng J 195:140–148CrossRef
41.
Meng ZX, Zheng W, Li L, Zheng YF (2010) Fabrication and characterization of three-dimensional nanofiber membrance of PCL–MWCNTs by electrospinning. Mater Sci Eng C 30(7):1014–1021CrossRef
42.
Hadjianfar M, Semnani D, Varshosaz J (2019) An investigation on polycaprolactone/chitosan/Fe3O4 nanofibrous composite used for hyperthermia. Polym Adv Technol 30(11):2729–2741CrossRef
43.
ASTM F (2004) 1635–04–standart test method for in vitro degradation testing of hydrolytically degradable polymer resins and fabricated forms for surgical implants. American Society for Testing and Materials International, West Conshohocken, PA
44.
Arifin DY, Lee LY, Wang CH (2006) Mathematical modeling and simulation of drug release from microspheres: Implications to drug delivery systems. Adv Drug Deliv Rev 58(12–13):1274–1325CrossRef
45.
Dash S, Murthy PN, Nath L, Chowdhury P (2010) Kinetic modeling on drug release from controlled drug delivery systems. Acta Poloniae Pharmaceutica 67(3):217–23
46.
Hu J, Zeng F, Wei J, Chen Y, Chen Y (2014) Novel controlled drug delivery system for multiple drugs based on electrospun nanofibers containing nanomicelles. J Biomater Sci Polym Ed 25(3):257–268CrossRef
47.
Chiu LCM, Ho TS, Wong EYL, Ooi VE (2006) Ethyl acetate extract of Patrinia scabiosaefolia downregulates anti-apoptotic Bcl-2/Bcl-XL expression, and induces apoptosis in human breast carcinoma MCF-7 cells independent of caspase-9 activation. J Ethnopharmacol 105(1–2):263–268CrossRef
48.
Berridge MV, Herst PM, Tan AS (2005) Tetrazolium dyes as tools in cell biology: new insights into their cellular reduction. Biotechnol Annu Rev 11:127–152CrossRef
49.
Huang ZM, Zhang YZ, Ramakrishna S, Lim CT (2004) Electrospinning and mechanical characterization of gelatin nanofibers. Polymer 45(15):5361–5368CrossRef
50.
Liu LQ, Tasis D, Prato M, Wagner HD (2007) Tensile mechanics of electrospun multiwalled nanotube/poly (methyl methacrylate) nanofibers. Adv Mater 19(9):1228–1233CrossRef
51.
Jeong JS, Moon JS, Jeon SY, Park JH, Alegaonkar PS, Yoo JB (2007) Mechanical properties of electrospun PVA/MWNTs composite nanofibers. Thin Solid Films 515(12):5136–5141CrossRef
52.
Moniruzzaman M, Chattopadhyay J, Billups WE, Winey KI (2007) Tuning the mechanical properties of SWNT/nylon 6, 10 composites with flexible spacers at the interface. Nano Lett 7(5):1178–1185CrossRef
53.
Yao ZC, Jin LJ, Ahmad Z, Huang J, Chang MW, Li JS (2017) Ganoderma lucidum polysaccharide loaded sodium alginate micro-particles prepared via electrospraying in controlled deposition environments. Int J Pharmaceut 524(1–2):148–158CrossRef
54.
Zhou W, Lu P, Sun L, Ji C, Dong J (2012) Diffusion and binding of 5-fluorouracil in non-ionic hydrogels with interpolymer complexation. Int J Pharmaceut 431(1–2):53–60CrossRef
Metadaten
Titel
Poly (ε-caprolactone)/poly (N-vinyl-2-pyrrolidone) core–shell nanofibers loaded by multi-walled carbon nanotubes and 5-fluorouracil: an anticancer drug delivery system
verfasst von
Mina Nasari
Dariush Semnani
Mehdi Hadjianfar
Saeid Amanpour
Publikationsdatum
14.05.2020
Verlag
Springer US
Erschienen in
Journal of Materials Science / Ausgabe 23/2020
Print ISSN: 0022-2461
Elektronische ISSN: 1573-4803
DOI
https://doi.org/10.1007/s10853-020-04784-3

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