Skip to main content
Erschienen in:
Buchtitelbild

2016 | OriginalPaper | Buchkapitel

Potential and Challenges of Graphene in Medicine

verfasst von : Marta Skoda, Ilona Dudek, Dariusz Szukiewicz

Erschienen in: Graphene-based Materials in Health and Environment

Verlag: Springer International Publishing

Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.

search-config
loading …

Abstract

Graphene due to its excellent properties has attracted the great attention in the area of nanomedicine. Due to the high surface area and capability of biofunctionalization graphene provides an efficient platform for drug and gene delivery. Many studies indicate that graphene is an attractive tool for cancer diagnosis and therapy, allowing the improvement of already existing techniques by providing more precision and effectiveness in cancer treatment and also by reducing secondary side effects. Furthermore, graphene is able to induce tissue-specific inductive capabilities which are desirable in tissue engineering and its high biocompatiblity makes it very suitable for the growth and maintenence of adherent cells. In vitro studies show that graphene promotes stem cell growth and differentiation which makes it a valuable nanomaterial in regenerative medicine. However, because of the variety of different forms of graphene and different methods of synthesis, the existing findings regarding graphene toxicity and biological interactions are ambiguous and sometimes even contradictory. The inconsistency of available data and the lack of sufficient information make it hard to fully assess the suitability of graphene as a biomaterial or nanocarrier. Indeed, more systematic and standarized research procedures in graphene production are required. In this chapter we will focus on the possible applications of graphene-based materials in numerous areas of medicine such as cancer therapy, drug and gene delivery, tissue engineering and bioimaging.

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 390 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Maschinenbau + Werkstoffe




 

Jetzt Wissensvorsprung sichern!

Literatur
1.
Zurück zum Zitat Singh Z (2016) Applications and toxicity of graphene family nanomaterials and their composites. Nanotechnol Sci Appl 16(9):15–28CrossRef Singh Z (2016) Applications and toxicity of graphene family nanomaterials and their composites. Nanotechnol Sci Appl 16(9):15–28CrossRef
2.
Zurück zum Zitat Bolotin K, Sikes K, Jiang Z (2008) Ultrahigh electron mobility in suspended graphen. State Commun 146:351–355CrossRef Bolotin K, Sikes K, Jiang Z (2008) Ultrahigh electron mobility in suspended graphen. State Commun 146:351–355CrossRef
3.
Zurück zum Zitat Wei Y, Wang B, Wu J, Yang R, Dunn ML (2013) Bending rigidity and Gaussian bending stiffness of single-layered graphene. Nano Lett 13(1):26–30CrossRef Wei Y, Wang B, Wu J, Yang R, Dunn ML (2013) Bending rigidity and Gaussian bending stiffness of single-layered graphene. Nano Lett 13(1):26–30CrossRef
4.
Zurück zum Zitat Seabra AB, Paula AJ, De Lima R, Alves OL, Duran N (2014) Nanotoxicity of graphene and graphene oxide. Chem Res Toxicol 27(2):159–168CrossRef Seabra AB, Paula AJ, De Lima R, Alves OL, Duran N (2014) Nanotoxicity of graphene and graphene oxide. Chem Res Toxicol 27(2):159–168CrossRef
5.
Zurück zum Zitat Russier J, Treossi E, Scarsi A, Perrozzi F, Dumortier H, Ottaviano L, Meneghetti M, Palermo V, Bianco A (2013) Evidencing the mask effect of graphene oxide: a comparative study on primary human and murine phagocytic cells. Nanoscale 5(22):11234–11247CrossRef Russier J, Treossi E, Scarsi A, Perrozzi F, Dumortier H, Ottaviano L, Meneghetti M, Palermo V, Bianco A (2013) Evidencing the mask effect of graphene oxide: a comparative study on primary human and murine phagocytic cells. Nanoscale 5(22):11234–11247CrossRef
6.
Zurück zum Zitat Li S, Stein AJ, Kruger A, Leblanc RM (2013) Head groups of lipids govern the interaction and orientation between graphene oxide and lipids. J Phys Chem C 117:16150–16158CrossRef Li S, Stein AJ, Kruger A, Leblanc RM (2013) Head groups of lipids govern the interaction and orientation between graphene oxide and lipids. J Phys Chem C 117:16150–16158CrossRef
7.
Zurück zum Zitat Jaworski S, Sawosz E, Grodzik M, Winnicka A, Prasek M, Wierzbicki M, Chwalibog A (2013) In vitro evaluation of the effects of graphene platelets on glioblastoma multiforme cells. Int J Nanomed 8:413–420 Jaworski S, Sawosz E, Grodzik M, Winnicka A, Prasek M, Wierzbicki M, Chwalibog A (2013) In vitro evaluation of the effects of graphene platelets on glioblastoma multiforme cells. Int J Nanomed 8:413–420
8.
Zurück zum Zitat De Marzi L et al (2014) Flake sizedependent cyto and genotoxic evaluation of graphene oxide on in vitro A549, CaCo2 and vero cell lines. J Biol Regul Homeost Agents 28(2):281–289 De Marzi L et al (2014) Flake sizedependent cyto and genotoxic evaluation of graphene oxide on in vitro A549, CaCo2 and vero cell lines. J Biol Regul Homeost Agents 28(2):281–289
9.
Zurück zum Zitat Liu Y et al (2013) Graphene oxide can induce in vitro and in vivo mutagenesis. Sci Rep 3, article 3469 Liu Y et al (2013) Graphene oxide can induce in vitro and in vivo mutagenesis. Sci Rep 3, article 3469
10.
Zurück zum Zitat Hinzmann M et al (2014) Nanoparticles containing allotropes of carbon have genotoxic effects on glioblastoma multiforme cells. Int J Nanomed 15(9):2409–2417 Hinzmann M et al (2014) Nanoparticles containing allotropes of carbon have genotoxic effects on glioblastoma multiforme cells. Int J Nanomed 15(9):2409–2417
11.
Zurück zum Zitat Goenka S, Sant V, Sant S (2014) Graphene-based nanomaterials for drug delivery and tissue engineering. J Control Release 10(173):75–88CrossRef Goenka S, Sant V, Sant S (2014) Graphene-based nanomaterials for drug delivery and tissue engineering. J Control Release 10(173):75–88CrossRef
12.
Zurück zum Zitat Kiew SF, Kiew LV, Lee HB, Imae T, Chung LY (2016) Assessing biocompatibility of graphene oxide-based nanocarriers: a review. J Control Release 28(226):217–228CrossRef Kiew SF, Kiew LV, Lee HB, Imae T, Chung LY (2016) Assessing biocompatibility of graphene oxide-based nanocarriers: a review. J Control Release 28(226):217–228CrossRef
13.
Zurück zum Zitat Luo N, Ni D, Yue H, Wei W, Ma G (2015) Surface-engineered graphene navigate divergent biological outcomes toward macrophages. ACS Appl Mater Interfaces 7:5239–5247CrossRef Luo N, Ni D, Yue H, Wei W, Ma G (2015) Surface-engineered graphene navigate divergent biological outcomes toward macrophages. ACS Appl Mater Interfaces 7:5239–5247CrossRef
14.
Zurück zum Zitat Miao W, Shim G, Lee S, Lee S, Choe YS, Oh YK (2013) Safety and tumor tissue accumulation of pegylated graphene oxide nanosheets for co-delivery of anticancer drug and photosensitizer. Biomaterials 34(13):3402–3410CrossRef Miao W, Shim G, Lee S, Lee S, Choe YS, Oh YK (2013) Safety and tumor tissue accumulation of pegylated graphene oxide nanosheets for co-delivery of anticancer drug and photosensitizer. Biomaterials 34(13):3402–3410CrossRef
15.
Zurück zum Zitat Ding Z, Zhang Z, Ma H, Chen Y (2014) In vitro hemocompatibility and toxic mechanism of graphene oxide on human peripheral blood T lymphocytes and serum albumin. ACS Appl Mater Interfaces 6(22):19797–19807CrossRef Ding Z, Zhang Z, Ma H, Chen Y (2014) In vitro hemocompatibility and toxic mechanism of graphene oxide on human peripheral blood T lymphocytes and serum albumin. ACS Appl Mater Interfaces 6(22):19797–19807CrossRef
16.
Zurück zum Zitat Sasidharan et al (2012) Hemocompatibility and macrophage response of pristine and functionalized graphene. Small 8(8):1251–1263CrossRef Sasidharan et al (2012) Hemocompatibility and macrophage response of pristine and functionalized graphene. Small 8(8):1251–1263CrossRef
17.
Zurück zum Zitat Dudek I, Skoda M, Jarosz A, Szukiewicz D (2015) The molecular influence of graphene and graphene oxide on the immune system under in vitro and in vivo conditions. Arch Immunol Ther Exp (Warsz) 2015:1–21 Dudek I, Skoda M, Jarosz A, Szukiewicz D (2015) The molecular influence of graphene and graphene oxide on the immune system under in vitro and in vivo conditions. Arch Immunol Ther Exp (Warsz) 2015:1–21
18.
Zurück zum Zitat Li Y, Liu Y, Fu Y et al (2012) The triggering of apoptosis in macrophages by pristine graphene through the MAPK and TGF-beta signaling pathways. Biomaterials 33(2):402–411CrossRef Li Y, Liu Y, Fu Y et al (2012) The triggering of apoptosis in macrophages by pristine graphene through the MAPK and TGF-beta signaling pathways. Biomaterials 33(2):402–411CrossRef
19.
Zurück zum Zitat Zhou H et al (2014) The inhibition of migration and invasion of cancer cells by graphene via the impairment of mitochondrial respiration. Biomaterials 35(5):1597–1607CrossRef Zhou H et al (2014) The inhibition of migration and invasion of cancer cells by graphene via the impairment of mitochondrial respiration. Biomaterials 35(5):1597–1607CrossRef
20.
Zurück zum Zitat Hinzmann V et al (2014) Nanoparticles containing allotropes of carbon have genotoxic effects on glioblastoma multiforme cells. Int J Nanomed 15(9):2409–2417 Hinzmann V et al (2014) Nanoparticles containing allotropes of carbon have genotoxic effects on glioblastoma multiforme cells. Int J Nanomed 15(9):2409–2417
21.
Zurück zum Zitat Zhou H, Zhao K, Wei L et al (2012) The interactions between pristine graphene and macrophages and the production of cytokines/chemokines via TLR- and NF-kB-related signaling pathways. Biomaterials 33:6933–6942CrossRef Zhou H, Zhao K, Wei L et al (2012) The interactions between pristine graphene and macrophages and the production of cytokines/chemokines via TLR- and NF-kB-related signaling pathways. Biomaterials 33:6933–6942CrossRef
22.
Zurück zum Zitat Zhi X, Fang H, Bao C, Shen G, Zhang J, Wang K, Guo S, Wan T, Cui D (2013) The immunotoxicity of graphene oxides and the effect of PVP-coating. Biomaterials 34(21):5254–5261CrossRef Zhi X, Fang H, Bao C, Shen G, Zhang J, Wang K, Guo S, Wan T, Cui D (2013) The immunotoxicity of graphene oxides and the effect of PVP-coating. Biomaterials 34(21):5254–5261CrossRef
23.
Zurück zum Zitat Liu J, Cui L, Losic D (2013) Graphene and graphene oxide as new nanocarriers for drug delivery applications. Acta Biomater 9(12):9243–9257CrossRef Liu J, Cui L, Losic D (2013) Graphene and graphene oxide as new nanocarriers for drug delivery applications. Acta Biomater 9(12):9243–9257CrossRef
24.
Zurück zum Zitat Orecchioni M, Cabizza R, Bianco A, Delogu LG (2015) Graphene as cancer theranostic tool: progress and future challenges. Theranostics 5(7):710–723CrossRef Orecchioni M, Cabizza R, Bianco A, Delogu LG (2015) Graphene as cancer theranostic tool: progress and future challenges. Theranostics 5(7):710–723CrossRef
26.
Zurück zum Zitat Zhang G, Zeng X, Ping L (2013) Nanomaterials in cancer-therapy drug delivery system. J Biomed Nanotechnol 9:741–750CrossRef Zhang G, Zeng X, Ping L (2013) Nanomaterials in cancer-therapy drug delivery system. J Biomed Nanotechnol 9:741–750CrossRef
27.
Zurück zum Zitat Zeng S, Baillargeat D, Ho H, Yong K (2014) Nanomaterials enhanced surface plasmon resonance for biological and chemical sensing applications. Chem Soc Rev 43:3426–3452CrossRef Zeng S, Baillargeat D, Ho H, Yong K (2014) Nanomaterials enhanced surface plasmon resonance for biological and chemical sensing applications. Chem Soc Rev 43:3426–3452CrossRef
28.
Zurück zum Zitat Depan D, Shah J, Misra RDK (2011) Controlled release of drug from folate-decorated and graphene mediated drug delivery system: synthesis, loading efficiency, and drug release response. Mater Sci Eng C 31:1305–1312CrossRef Depan D, Shah J, Misra RDK (2011) Controlled release of drug from folate-decorated and graphene mediated drug delivery system: synthesis, loading efficiency, and drug release response. Mater Sci Eng C 31:1305–1312CrossRef
29.
Zurück zum Zitat Yang XY, Zhang XY, Liu ZF, Ma YF, Huang Y, Chen Y (2008) High-efficiency loading and controlled release of doxorubicin hydrochloride on graphene oxide. J Phys Chem C 112:17554–17558CrossRef Yang XY, Zhang XY, Liu ZF, Ma YF, Huang Y, Chen Y (2008) High-efficiency loading and controlled release of doxorubicin hydrochloride on graphene oxide. J Phys Chem C 112:17554–17558CrossRef
30.
Zurück zum Zitat Bao H, Pan Y, Ping Y, Sahoo NG, Wu T, Li L, Li J, Gan LH (2011) Chitosan-functionalized graphene oxide as a nanocarrier for drug and gene delivery. Small 7(11):1569–1578CrossRef Bao H, Pan Y, Ping Y, Sahoo NG, Wu T, Li L, Li J, Gan LH (2011) Chitosan-functionalized graphene oxide as a nanocarrier for drug and gene delivery. Small 7(11):1569–1578CrossRef
31.
Zurück zum Zitat Liu Z, Robinson JT, Sun X, Dai H (2008) PEGylated nanographene oxide for delivery of water-insoluble cancer drugs. J Am Chem Soc 130(33):10876–10877CrossRef Liu Z, Robinson JT, Sun X, Dai H (2008) PEGylated nanographene oxide for delivery of water-insoluble cancer drugs. J Am Chem Soc 130(33):10876–10877CrossRef
32.
Zurück zum Zitat Zhang L, Lu Z, Zhao Q, Huang J, Shen H, Zhang Z (2011) Enhanced chemotherapy efficacy by sequential delivery of siRNA and anticancer drugs using PEI-grafted graphene oxide. Small 7(4):417–545CrossRef Zhang L, Lu Z, Zhao Q, Huang J, Shen H, Zhang Z (2011) Enhanced chemotherapy efficacy by sequential delivery of siRNA and anticancer drugs using PEI-grafted graphene oxide. Small 7(4):417–545CrossRef
33.
Zurück zum Zitat Luo N, Ni D, Yue H, Wei W, Ma G (2015) Surface-engineered graphene navigate divergent biological outcomes toward macrophages. ACS Appl Mater Interfaces 7(9):5239–5247CrossRef Luo N, Ni D, Yue H, Wei W, Ma G (2015) Surface-engineered graphene navigate divergent biological outcomes toward macrophages. ACS Appl Mater Interfaces 7(9):5239–5247CrossRef
34.
Zurück zum Zitat Kim H, Lee D, Kim J, Kim TI, Kim WJ (2013) Photothermally triggered cytosolic drug delivery via endosome disruption using a functionalized reduced graphene oxide. ACS Nano 7:6735–6746CrossRef Kim H, Lee D, Kim J, Kim TI, Kim WJ (2013) Photothermally triggered cytosolic drug delivery via endosome disruption using a functionalized reduced graphene oxide. ACS Nano 7:6735–6746CrossRef
35.
Zurück zum Zitat Yang X, Zhang X, Ma Y, Huang Y, Wang Y, Chen Y (2009) Superparamagnetic graphene oxide-Fe(3) O(4) nanoparticles hybrid for controlled targeted drug carriers. J Mater Chem 19(18):2710–2714CrossRef Yang X, Zhang X, Ma Y, Huang Y, Wang Y, Chen Y (2009) Superparamagnetic graphene oxide-Fe(3) O(4) nanoparticles hybrid for controlled targeted drug carriers. J Mater Chem 19(18):2710–2714CrossRef
36.
Zurück zum Zitat Yang X, Wang Y, Huang X, Ma Y, Huang Y, Yang R, Duan H, Chen Y (2011) Multi-functionalized graphene oxide based anticancer drug-carrier with dualtargeting function and pH-sensitivity. J Mater Chem 21(10):3448–3454CrossRef Yang X, Wang Y, Huang X, Ma Y, Huang Y, Yang R, Duan H, Chen Y (2011) Multi-functionalized graphene oxide based anticancer drug-carrier with dualtargeting function and pH-sensitivity. J Mater Chem 21(10):3448–3454CrossRef
37.
Zurück zum Zitat Wang C, Li J, Amatore C, Chen Y, Jiang H, Wang XM (2011) Gold nanoclusters and graphene nanocomposites for drug delivery and imaging of cancer cells. Angew Chem Int Ed Engl 50(49):11644–11648CrossRef Wang C, Li J, Amatore C, Chen Y, Jiang H, Wang XM (2011) Gold nanoclusters and graphene nanocomposites for drug delivery and imaging of cancer cells. Angew Chem Int Ed Engl 50(49):11644–11648CrossRef
38.
Zurück zum Zitat Bai J, Liu Y, Jiang X (2014) Multifunctional PEG-GO/CuS nanocomposites for near-infrared chemo-photothermal therapy. Biomaterials 35(22):5805–5813CrossRef Bai J, Liu Y, Jiang X (2014) Multifunctional PEG-GO/CuS nanocomposites for near-infrared chemo-photothermal therapy. Biomaterials 35(22):5805–5813CrossRef
39.
Zurück zum Zitat Jin L, Zeng X, Liu M, Deng Y, He N (2014) Current progress in gene delivery technology based on chemical methods and nano-carriers. Theranostics 4(3):240–255CrossRef Jin L, Zeng X, Liu M, Deng Y, He N (2014) Current progress in gene delivery technology based on chemical methods and nano-carriers. Theranostics 4(3):240–255CrossRef
40.
Zurück zum Zitat Chen B, Liu M, Zhang LM, Huang J, Yao J, Zhang Z (2011) Polyethylenimine-functionalized graphene oxide as an efficient gene delivery vector. J Mater Chem 21:7736–7741CrossRef Chen B, Liu M, Zhang LM, Huang J, Yao J, Zhang Z (2011) Polyethylenimine-functionalized graphene oxide as an efficient gene delivery vector. J Mater Chem 21:7736–7741CrossRef
41.
Zurück zum Zitat Lu CH, Yang HH, Zhu CL, Chen X, Chen GN (2009) A graphene platform for sensing biomolecules. Angew Chem Int Ed Engl 48(26):4785–4787CrossRef Lu CH, Yang HH, Zhu CL, Chen X, Chen GN (2009) A graphene platform for sensing biomolecules. Angew Chem Int Ed Engl 48(26):4785–4787CrossRef
42.
Zurück zum Zitat Zhi F, Dong H, Jia X, Guo W, Lu H, Yang Y, Ju H, Zhang X, Hu Y (2013) Functionalized graphene oxide mediated adriamycin delivery and miR-21 gene silencing to overcome tumor multidrug resistance in vitro. PLoS ONE 8(3):e60034CrossRef Zhi F, Dong H, Jia X, Guo W, Lu H, Yang Y, Ju H, Zhang X, Hu Y (2013) Functionalized graphene oxide mediated adriamycin delivery and miR-21 gene silencing to overcome tumor multidrug resistance in vitro. PLoS ONE 8(3):e60034CrossRef
43.
Zurück zum Zitat Yin D, Li Y, Lin H, Guo B, Du Y, Li X, Jia H, Zhao X, Tang J, Zhang L (2013) Functional graphene oxide as a plasmid-based Stat3 siRNA carrier inhibits mouse malignant melanoma growth in vivo. Nanotechnology 24(10):105102CrossRef Yin D, Li Y, Lin H, Guo B, Du Y, Li X, Jia H, Zhao X, Tang J, Zhang L (2013) Functional graphene oxide as a plasmid-based Stat3 siRNA carrier inhibits mouse malignant melanoma growth in vivo. Nanotechnology 24(10):105102CrossRef
44.
Zurück zum Zitat Tao Y, Ju E, Ren J, Qu X (2014) Immunostimulatory oligonucleotides-loaded cationic graphene oxide with photothermally enhanced immunogenicity for photothermal/immune cancer therapy. Biomaterials 35(37):9963–9971CrossRef Tao Y, Ju E, Ren J, Qu X (2014) Immunostimulatory oligonucleotides-loaded cationic graphene oxide with photothermally enhanced immunogenicity for photothermal/immune cancer therapy. Biomaterials 35(37):9963–9971CrossRef
45.
Zurück zum Zitat Yang K, Feng L, Shi X, Liu Z (2013) Nano-graphene in biomedicine: theranostic applications. Chem Soc Rev 42(2):530–547CrossRef Yang K, Feng L, Shi X, Liu Z (2013) Nano-graphene in biomedicine: theranostic applications. Chem Soc Rev 42(2):530–547CrossRef
46.
Zurück zum Zitat Robinson JT, Tabakman SM, Liang Y, Wang H, Casalongue HS, Vinh D, Dai H (2011) Ultrasmall reduced graphene oxide with high near-infrared absorbance for photothermal therapy. J Am Chem Soc 133(17):6825–6831CrossRef Robinson JT, Tabakman SM, Liang Y, Wang H, Casalongue HS, Vinh D, Dai H (2011) Ultrasmall reduced graphene oxide with high near-infrared absorbance for photothermal therapy. J Am Chem Soc 133(17):6825–6831CrossRef
47.
Zurück zum Zitat Yang K, Zhang S, Zhang G, Sun X, Lee ST, Liu Z (2010) Graphene in mice: ultrahigh in vivo tumor uptake and efficient photothermal therapy. Nano Lett 10:3318–3323CrossRef Yang K, Zhang S, Zhang G, Sun X, Lee ST, Liu Z (2010) Graphene in mice: ultrahigh in vivo tumor uptake and efficient photothermal therapy. Nano Lett 10:3318–3323CrossRef
48.
Zurück zum Zitat Sheng Z et al (2013) Protein-assisted fabrication of nano-reduced graphene oxide for combined in vivo photoacoustic imaging and photothermal therapy. Biomaterials 34(21):5236–5243CrossRef Sheng Z et al (2013) Protein-assisted fabrication of nano-reduced graphene oxide for combined in vivo photoacoustic imaging and photothermal therapy. Biomaterials 34(21):5236–5243CrossRef
49.
Zurück zum Zitat Cheon YA, Bae JH, Chung BG (2016) Reduced graphene oxide nanosheet for chemo-photothermal therapy. Langmuir 32(11):2731–2736CrossRef Cheon YA, Bae JH, Chung BG (2016) Reduced graphene oxide nanosheet for chemo-photothermal therapy. Langmuir 32(11):2731–2736CrossRef
50.
Zurück zum Zitat Feng L, Yang X, Shi X, Tan X, Peng R, Wang J, Liu Z (2013) Polyethylene glycol and polyethylenimine dual-functionalized nano-graphene oxide for photothermally enhanced gene delivery. Small 9:1989–1997CrossRef Feng L, Yang X, Shi X, Tan X, Peng R, Wang J, Liu Z (2013) Polyethylene glycol and polyethylenimine dual-functionalized nano-graphene oxide for photothermally enhanced gene delivery. Small 9:1989–1997CrossRef
51.
Zurück zum Zitat Gao S, Zhang L, Wang G, Yang K, Chen M, Tian R, Ma Q, Zhu L (2016) Hybrid graphene/Au activatable theranostic agent for multimodalities imaging guided enhanced photothermal therapy. Biomaterials 79:36–45CrossRef Gao S, Zhang L, Wang G, Yang K, Chen M, Tian R, Ma Q, Zhu L (2016) Hybrid graphene/Au activatable theranostic agent for multimodalities imaging guided enhanced photothermal therapy. Biomaterials 79:36–45CrossRef
52.
Zurück zum Zitat Huang P, Xu C, Lin J, Wang C, Wang X, Zhang C, Zhou X, Guo S, Cui D (2011) Folic acid-conjugated graphene oxide loaded with photosensitizers for targeting photodynamic therapy. Theranostics 13(1):240–250CrossRef Huang P, Xu C, Lin J, Wang C, Wang X, Zhang C, Zhou X, Guo S, Cui D (2011) Folic acid-conjugated graphene oxide loaded with photosensitizers for targeting photodynamic therapy. Theranostics 13(1):240–250CrossRef
53.
Zurück zum Zitat Sahu A, Choi WI, Lee JH, Tae G (2013) Graphene oxide mediated delivery of methylene blue for combined photodynamic and photothermal therapy. Biomaterials 34:6239–6248CrossRef Sahu A, Choi WI, Lee JH, Tae G (2013) Graphene oxide mediated delivery of methylene blue for combined photodynamic and photothermal therapy. Biomaterials 34:6239–6248CrossRef
54.
Zurück zum Zitat Zhou L, Zhou L, Wei S, Ge X, Zhou J, Jiang H, Li F, Shen J (2014) Combination of chemotherapy and photodynamic therapy using graphene oxide as drug delivery system. J Photochem Photobiol, B 5(135):7–16CrossRef Zhou L, Zhou L, Wei S, Ge X, Zhou J, Jiang H, Li F, Shen J (2014) Combination of chemotherapy and photodynamic therapy using graphene oxide as drug delivery system. J Photochem Photobiol, B 5(135):7–16CrossRef
55.
Zurück zum Zitat Wei Y, Zhou F, Zhang D, Chen Q, Xing D (2016) A graphene oxide based smart drug delivery system for tumor mitochondria-targeting photodynamic therapy. Nanoscale 8(6):3530–3538CrossRef Wei Y, Zhou F, Zhang D, Chen Q, Xing D (2016) A graphene oxide based smart drug delivery system for tumor mitochondria-targeting photodynamic therapy. Nanoscale 8(6):3530–3538CrossRef
56.
Zurück zum Zitat Taratula O, Patel M, Schumann C, Naleway MA, Pang AJ, He H (2015) Phthalocyanine-loaded graphene nanoplatform for imaging-guided combinatorial phototherapy. Int J Nanomed 24(10):2347–2362CrossRef Taratula O, Patel M, Schumann C, Naleway MA, Pang AJ, He H (2015) Phthalocyanine-loaded graphene nanoplatform for imaging-guided combinatorial phototherapy. Int J Nanomed 24(10):2347–2362CrossRef
57.
Zurück zum Zitat Li JL, Tang B, Yuan B, Sun L, Wang XG (2013) A review of optical imaging and therapy using nanosized graphene and graphene oxide. Biomaterials 34:9519–9534CrossRef Li JL, Tang B, Yuan B, Sun L, Wang XG (2013) A review of optical imaging and therapy using nanosized graphene and graphene oxide. Biomaterials 34:9519–9534CrossRef
58.
Zurück zum Zitat Yoo JM, Kang JH, Hong BH (2015) Graphene based nanomaterials for versatile imaging studies. Chem Soc Rev 44(14):4835–4852CrossRef Yoo JM, Kang JH, Hong BH (2015) Graphene based nanomaterials for versatile imaging studies. Chem Soc Rev 44(14):4835–4852CrossRef
59.
Zurück zum Zitat Markovic ZM, Ristic BZ, Arsikinb KM, Klisic DG, Harhaji-Trajkovic LM, Todorovic-Markovic BM, Kepic DP, Kravic-Stevovic TK, Jovanovic SP, Milenkovic MM, Milivojevic DD, Bumbasirevic VZ, Dramicanina MD, Trajkovic VS (2012) Graphene quantum dots as autophagy-inducing photodynamic agents. Biomaterials 33(29):7084–7092CrossRef Markovic ZM, Ristic BZ, Arsikinb KM, Klisic DG, Harhaji-Trajkovic LM, Todorovic-Markovic BM, Kepic DP, Kravic-Stevovic TK, Jovanovic SP, Milenkovic MM, Milivojevic DD, Bumbasirevic VZ, Dramicanina MD, Trajkovic VS (2012) Graphene quantum dots as autophagy-inducing photodynamic agents. Biomaterials 33(29):7084–7092CrossRef
60.
Zurück zum Zitat Nahain AA, Lee JE, In I, Lee H, Lee KD, Jeong JH, Park SY (2013) Target delivery and cell imaging using hyaluronic acid-functionalized graphene quantum dots. Mol Pharm 10(10):3736–3744CrossRef Nahain AA, Lee JE, In I, Lee H, Lee KD, Jeong JH, Park SY (2013) Target delivery and cell imaging using hyaluronic acid-functionalized graphene quantum dots. Mol Pharm 10(10):3736–3744CrossRef
61.
Zurück zum Zitat Zheng XT, Than A, Ananthanaraya A, Kim DH, Chen P (2013) Graphene quantum dots as universal fluorophores and their use in revealing regulated trafficking of insulin receptors in adipocytes. ACS Nano 7(7):6278–6286CrossRef Zheng XT, Than A, Ananthanaraya A, Kim DH, Chen P (2013) Graphene quantum dots as universal fluorophores and their use in revealing regulated trafficking of insulin receptors in adipocytes. ACS Nano 7(7):6278–6286CrossRef
62.
Zurück zum Zitat Zhao Y, Liu Q, Shakoor S, Gong JR, Wang D (2015) Transgenerational safety of nitrogen-doped graphene quantum dots and the underlying cellular mechanism in Caenorhabditis elegans. Toxicol Res 4:270–280CrossRef Zhao Y, Liu Q, Shakoor S, Gong JR, Wang D (2015) Transgenerational safety of nitrogen-doped graphene quantum dots and the underlying cellular mechanism in Caenorhabditis elegans. Toxicol Res 4:270–280CrossRef
63.
Zurück zum Zitat Gao Y, Zou X, Zhao JX, Li Y, Su X (2013) Graphene oxide-based magnetic fluorescent hybrids for drug delivery and cellular imaging. Colloids Surf, B 112:128–133CrossRef Gao Y, Zou X, Zhao JX, Li Y, Su X (2013) Graphene oxide-based magnetic fluorescent hybrids for drug delivery and cellular imaging. Colloids Surf, B 112:128–133CrossRef
64.
Zurück zum Zitat Wang Y, Huang R, Liang G, Zhang Z, Zhang P, Yu S et al (2014) MRI-visualized, dual-targeting, combined tumor therapy using magnetic graphene-based mesoporous silica. Small 10:109–116CrossRef Wang Y, Huang R, Liang G, Zhang Z, Zhang P, Yu S et al (2014) MRI-visualized, dual-targeting, combined tumor therapy using magnetic graphene-based mesoporous silica. Small 10:109–116CrossRef
65.
Zurück zum Zitat Shi S, Yang K, Hong H, Valdovinos HF, Nayak TR, Zhang Y et al (2013) Tumor vasculature targeting and imaging in living mice with reduced graphene oxide. Biomaterials 34:3002–3009CrossRef Shi S, Yang K, Hong H, Valdovinos HF, Nayak TR, Zhang Y et al (2013) Tumor vasculature targeting and imaging in living mice with reduced graphene oxide. Biomaterials 34:3002–3009CrossRef
66.
Zurück zum Zitat Schedin F, Lidorikis E, Lombardo A, Kravets V, Geim A, Grigorenko A, Novoselov K, Ferrari A (2010) Surface-enhanced Raman spectroscopy of graphene. ACS Nano 4(10):5617–5626CrossRef Schedin F, Lidorikis E, Lombardo A, Kravets V, Geim A, Grigorenko A, Novoselov K, Ferrari A (2010) Surface-enhanced Raman spectroscopy of graphene. ACS Nano 4(10):5617–5626CrossRef
67.
Zurück zum Zitat Sun S, Wu P (2011) Competitive surface-enhanced Raman scattering effects in noble metal nanoparticle-decorated graphene sheets. Phys Chem Chem Phys 13(47):21116–21120CrossRef Sun S, Wu P (2011) Competitive surface-enhanced Raman scattering effects in noble metal nanoparticle-decorated graphene sheets. Phys Chem Chem Phys 13(47):21116–21120CrossRef
68.
Zurück zum Zitat Huang J, Zong C, Shen H, Liu M, Chen B, Ren B, Zhang Z (2012) Mechanism of cellular uptake of graphene oxide studied by surface-enhanced Raman spectroscopy. Small 8(16):2577–2584CrossRef Huang J, Zong C, Shen H, Liu M, Chen B, Ren B, Zhang Z (2012) Mechanism of cellular uptake of graphene oxide studied by surface-enhanced Raman spectroscopy. Small 8(16):2577–2584CrossRef
69.
Zurück zum Zitat Shadjou N, Hasanzadeh M (2016) Graphene and its nanostructure derivatives for use in bone tissue engineering: recent advances. J Biomed Mater Res, Part A 104(5):1250–1275CrossRef Shadjou N, Hasanzadeh M (2016) Graphene and its nanostructure derivatives for use in bone tissue engineering: recent advances. J Biomed Mater Res, Part A 104(5):1250–1275CrossRef
70.
Zurück zum Zitat Li N, Cheng Y, Song Q, Jiang Z, Tang M, Cheng G (2014) Graphene meets biology. Chin Sci Bull 59(13):1341–1354CrossRef Li N, Cheng Y, Song Q, Jiang Z, Tang M, Cheng G (2014) Graphene meets biology. Chin Sci Bull 59(13):1341–1354CrossRef
71.
Zurück zum Zitat Park J et al (2015) Graphene potentiates the myocardial repair efficacy of mesenchymal stem cells by stimulating the expression of angiogenic growth factors and gap junction protein. Adv Funct Mater 25(17):2590–2600CrossRef Park J et al (2015) Graphene potentiates the myocardial repair efficacy of mesenchymal stem cells by stimulating the expression of angiogenic growth factors and gap junction protein. Adv Funct Mater 25(17):2590–2600CrossRef
72.
Zurück zum Zitat Annabi N et al (2016) Highly elastic and conductive human-based protein hybrid hydrogels. Adv Mater 28(1):40–49CrossRef Annabi N et al (2016) Highly elastic and conductive human-based protein hybrid hydrogels. Adv Mater 28(1):40–49CrossRef
73.
Zurück zum Zitat Podila R, Moore T, Alexis F, Rao AM (2013) Graphene coatings for enhanced hemo-compatibility of nitinol stents. RSC Adv 3:1660–1665CrossRef Podila R, Moore T, Alexis F, Rao AM (2013) Graphene coatings for enhanced hemo-compatibility of nitinol stents. RSC Adv 3:1660–1665CrossRef
74.
Zurück zum Zitat Cardenas L, MacLeod J, Lipton-Duffin J, Seifu DG, Popescu F, Siaj M, Mantovani D, Rosei F (2014) Reduced graphene oxide growth on 316L stainless steel for medical applications. Nanoscale 6(15):8664–8670CrossRef Cardenas L, MacLeod J, Lipton-Duffin J, Seifu DG, Popescu F, Siaj M, Mantovani D, Rosei F (2014) Reduced graphene oxide growth on 316L stainless steel for medical applications. Nanoscale 6(15):8664–8670CrossRef
75.
Zurück zum Zitat Park SY, Park J, Sim SH, Sung MG, Kim KS, Hong BH, Hong S (2011) Enhanced differentiation of human neural stem cells into neurons on graphene. Adv Mater 23(36):H263–H267CrossRef Park SY, Park J, Sim SH, Sung MG, Kim KS, Hong BH, Hong S (2011) Enhanced differentiation of human neural stem cells into neurons on graphene. Adv Mater 23(36):H263–H267CrossRef
76.
Zurück zum Zitat Lee JS, Lipatov A, Ha L, Shekhirev M, Andalib MN, Sinitskii A, Lim JY (2015) Graphene substrate for inducing neurite outgrowth. Biochem Biophys Res Commun 460(2):267–273CrossRef Lee JS, Lipatov A, Ha L, Shekhirev M, Andalib MN, Sinitskii A, Lim JY (2015) Graphene substrate for inducing neurite outgrowth. Biochem Biophys Res Commun 460(2):267–273CrossRef
77.
Zurück zum Zitat Feng ZQ, Wang T, Zhao B, Li J, Jin L (2015) Soft graphene nanofibers designed for the acceleration of nerve growth and development. Adv Mater 27(41):6462–6468CrossRef Feng ZQ, Wang T, Zhao B, Li J, Jin L (2015) Soft graphene nanofibers designed for the acceleration of nerve growth and development. Adv Mater 27(41):6462–6468CrossRef
78.
Zurück zum Zitat Li N, Zhang Q, Gao S, Song Q, Huang R, Wang L, Liu L, Dai J, Tang M, Cheng G (2013) Three-dimensional graphene foam as a biocompatible and conductive scaffold for neural stem cells. Sci Rep 3:1604 Li N, Zhang Q, Gao S, Song Q, Huang R, Wang L, Liu L, Dai J, Tang M, Cheng G (2013) Three-dimensional graphene foam as a biocompatible and conductive scaffold for neural stem cells. Sci Rep 3:1604
79.
Zurück zum Zitat Jakus AE, Secor EB, Rutz AL, Jordan SW, Hersam MC, Shah RN (2015) Three-dimensional printing of high-content graphene scaffolds for electronic and bio-medical applications. ACS Nano 9(4):4636–4648CrossRef Jakus AE, Secor EB, Rutz AL, Jordan SW, Hersam MC, Shah RN (2015) Three-dimensional printing of high-content graphene scaffolds for electronic and bio-medical applications. ACS Nano 9(4):4636–4648CrossRef
80.
Zurück zum Zitat Kalbacova M, Broz A, Kong J, Kalbac M (2010) Graphene substrates promote adherence of human osteoblasts and mesenchymal stromal cells. Carbon 48(15):4323–4329CrossRef Kalbacova M, Broz A, Kong J, Kalbac M (2010) Graphene substrates promote adherence of human osteoblasts and mesenchymal stromal cells. Carbon 48(15):4323–4329CrossRef
81.
Zurück zum Zitat Nayak et al (2011) Graphene for controlled and accelerated osteogenic differentiation of human mesenchymal stem cells. ACS Nano 5(6):4670–4678CrossRef Nayak et al (2011) Graphene for controlled and accelerated osteogenic differentiation of human mesenchymal stem cells. ACS Nano 5(6):4670–4678CrossRef
82.
Zurück zum Zitat Lee JU, Yoon D, Cheong H (2012) Estimation of Young’s modulus of graphene by Raman spectroscopy. Nano Lett 12(9):4444–4448CrossRef Lee JU, Yoon D, Cheong H (2012) Estimation of Young’s modulus of graphene by Raman spectroscopy. Nano Lett 12(9):4444–4448CrossRef
83.
Zurück zum Zitat Liu H, Cheng J, Chen F, Bai D, Shao C, Wang J, Xi P, Zeng Z (2014) Gelatin functionalized graphene oxide for mineralization of hydroxyapatite: biomimetic and in vitro evaluation. Nanoscale 6(10):5315–5322CrossRef Liu H, Cheng J, Chen F, Bai D, Shao C, Wang J, Xi P, Zeng Z (2014) Gelatin functionalized graphene oxide for mineralization of hydroxyapatite: biomimetic and in vitro evaluation. Nanoscale 6(10):5315–5322CrossRef
84.
Zurück zum Zitat Kumar S, Azam MD, Raj S, Kolanthai E, Vasu KS, Sood AK, Chatterjee K (2015) 3D scaffold alters cellular response to graphene in a polymer composite for orthopedic applications. J Biomed Mater Res B Appl Biomater 104(4):732–749 Kumar S, Azam MD, Raj S, Kolanthai E, Vasu KS, Sood AK, Chatterjee K (2015) 3D scaffold alters cellular response to graphene in a polymer composite for orthopedic applications. J Biomed Mater Res B Appl Biomater 104(4):732–749
85.
Zurück zum Zitat Xie H, Cao T, Gomes JV, Neto AHCN, Rosa V (2015) Two and three-dimensional graphene substrates to magnify osteogenic differentiation of periodontal ligament stem cells. Carbon 93:266–275CrossRef Xie H, Cao T, Gomes JV, Neto AHCN, Rosa V (2015) Two and three-dimensional graphene substrates to magnify osteogenic differentiation of periodontal ligament stem cells. Carbon 93:266–275CrossRef
86.
Zurück zum Zitat Nair M, Nancy D, Krishnan AG, Anjusree GS, Vadukumpully S, Nair SV (2015) Graphene oxide nanoflakes incorporated gelatin-hydroxyapatite scaffolds enhance osteogenic differentiation of human mesenchymal stem cells. Nanotechnology 26(16):161001CrossRef Nair M, Nancy D, Krishnan AG, Anjusree GS, Vadukumpully S, Nair SV (2015) Graphene oxide nanoflakes incorporated gelatin-hydroxyapatite scaffolds enhance osteogenic differentiation of human mesenchymal stem cells. Nanotechnology 26(16):161001CrossRef
87.
Zurück zum Zitat Liu L, Guo Y, Chen X, Li R, Li Z, Wang L, Wan Z, Li J, Hao Q, Li H, Zhang X (2012) Three-dimensional dynamic culture of pre-osteoblasts seeded in HA-CS/Col/nHAP composite scaffolds and treated with α-ZAL. Acta Biochim Biophys Sin (Shanghai) 44(8):669–677CrossRef Liu L, Guo Y, Chen X, Li R, Li Z, Wang L, Wan Z, Li J, Hao Q, Li H, Zhang X (2012) Three-dimensional dynamic culture of pre-osteoblasts seeded in HA-CS/Col/nHAP composite scaffolds and treated with α-ZAL. Acta Biochim Biophys Sin (Shanghai) 44(8):669–677CrossRef
88.
Zurück zum Zitat Nishida E, Miyaji H, Kato A, Takita H, Iwanaga T, Momose T, Ogawa K, Murakami S, Sugaya T, Kawanami M (2016) Graphene oxide scaffold accelerates cellular proliferative response and alveolar bone healing of tooth extraction socket. Int J Nanomed 11:2265–2277 Nishida E, Miyaji H, Kato A, Takita H, Iwanaga T, Momose T, Ogawa K, Murakami S, Sugaya T, Kawanami M (2016) Graphene oxide scaffold accelerates cellular proliferative response and alveolar bone healing of tooth extraction socket. Int J Nanomed 11:2265–2277
89.
Zurück zum Zitat Kanayama I, Miyaji H, Takita H, Nishida E, Tsuji M, Fugetsu B, Sun L, Inoue K, Ibara A, Akasaka T, Sugaya T, Kawanami M (2014) Comparative study of bioactivity of collagen scaffolds coated with graphene oxide and reduced graphene oxide. Int J Nanomed 11(9):3363–3373 Kanayama I, Miyaji H, Takita H, Nishida E, Tsuji M, Fugetsu B, Sun L, Inoue K, Ibara A, Akasaka T, Sugaya T, Kawanami M (2014) Comparative study of bioactivity of collagen scaffolds coated with graphene oxide and reduced graphene oxide. Int J Nanomed 11(9):3363–3373
90.
Zurück zum Zitat Depan D, Girase B, Shah JS, Misra RD (2011) Structure-process-property relationship of the polar graphene oxide-mediated cellular response and stimulated growth of osteoblasts on hybrid chitosan network structure nanocomposite scaffolds. Acta Biomater 7(9):3432–3445CrossRef Depan D, Girase B, Shah JS, Misra RD (2011) Structure-process-property relationship of the polar graphene oxide-mediated cellular response and stimulated growth of osteoblasts on hybrid chitosan network structure nanocomposite scaffolds. Acta Biomater 7(9):3432–3445CrossRef
91.
Zurück zum Zitat Girase B, Shah JS, Misra RDK (2012) Cellular mechanics of modulated osteoblasts functions in graphene oxide reinforced elastomers. Adv Eng Mater 14:B101–B111CrossRef Girase B, Shah JS, Misra RDK (2012) Cellular mechanics of modulated osteoblasts functions in graphene oxide reinforced elastomers. Adv Eng Mater 14:B101–B111CrossRef
92.
Zurück zum Zitat Gao Ch, Liu T, Shuai C, Peng S (2014) Enhancement mechanisms of graphene in nano-58S bioactive glass scaffold: mechanical and biological performance. Sci Rep 4, Art No. 4712 Gao Ch, Liu T, Shuai C, Peng S (2014) Enhancement mechanisms of graphene in nano-58S bioactive glass scaffold: mechanical and biological performance. Sci Rep 4, Art No. 4712
93.
Zurück zum Zitat Lee WG et al (2011) Origin of enhanced stem cell growth and differentiation on graphene and graphene oxide. ACS Nano 5(9):7332–7341 Lee WG et al (2011) Origin of enhanced stem cell growth and differentiation on graphene and graphene oxide. ACS Nano 5(9):7332–7341
94.
Zurück zum Zitat Zancanela DC et al (2016) Graphene oxide and titanium: synergistic effects on the biomineralization ability of osteoblast cultures. J Mater Sci Mater Med 27(4):71CrossRef Zancanela DC et al (2016) Graphene oxide and titanium: synergistic effects on the biomineralization ability of osteoblast cultures. J Mater Sci Mater Med 27(4):71CrossRef
95.
Zurück zum Zitat Tian T, Shi X, Cheng L, Luo Y, Dong Z et al (2014) Graphene-based nanocomposite as an effective, multifunctional, and recyclable antibacterial agent. ACS Appl Mater Interfaces 6:8542–8548 Tian T, Shi X, Cheng L, Luo Y, Dong Z et al (2014) Graphene-based nanocomposite as an effective, multifunctional, and recyclable antibacterial agent. ACS Appl Mater Interfaces 6:8542–8548
96.
Zurück zum Zitat Wang Y, Li Z, Wang J, Li J, Lin Y (2011) Graphene and graphene oxide: biofunctionalization and applications in biotechnology. Trends Biotechnol 29(5):205–212CrossRef Wang Y, Li Z, Wang J, Li J, Lin Y (2011) Graphene and graphene oxide: biofunctionalization and applications in biotechnology. Trends Biotechnol 29(5):205–212CrossRef
97.
Zurück zum Zitat Lee WC, Lim CH, Kenry, Su C, Loh KP, Lim CT (2015) Cell-assembled graphene biocomposite for enhanced chondrogenic differentiation. Small 11(8):963–969CrossRef Lee WC, Lim CH, Kenry, Su C, Loh KP, Lim CT (2015) Cell-assembled graphene biocomposite for enhanced chondrogenic differentiation. Small 11(8):963–969CrossRef
98.
Zurück zum Zitat Yoon HH, Bhang SH, Kim T, Yu T, Hyeon T, Kim BS (2014) Dual roles of graphene oxide in chondrogenic differentiation of adult stem cells: cell-adhesion substrate and growth factor-delivery carrier. Adv Funct Mater 24:6455–6464CrossRef Yoon HH, Bhang SH, Kim T, Yu T, Hyeon T, Kim BS (2014) Dual roles of graphene oxide in chondrogenic differentiation of adult stem cells: cell-adhesion substrate and growth factor-delivery carrier. Adv Funct Mater 24:6455–6464CrossRef
99.
Zurück zum Zitat Liao L, Qu Y, Chu B, Zhang X, Qian Z (2015) Biodegradable CSMA/PECA/graphene porous hybrid scaffold for cartilage tissue engineering. Sci Rep 5:9879CrossRef Liao L, Qu Y, Chu B, Zhang X, Qian Z (2015) Biodegradable CSMA/PECA/graphene porous hybrid scaffold for cartilage tissue engineering. Sci Rep 5:9879CrossRef
100.
Zurück zum Zitat Li Z, Wang H, Yang B, Sun Y, Huo R (2015) Three-dimensional graphene foams loaded with bone marrow derived mesenchymal stem cells promote skin wound healing with reduced scarring. Mater Sci Eng, C 27:181–188CrossRef Li Z, Wang H, Yang B, Sun Y, Huo R (2015) Three-dimensional graphene foams loaded with bone marrow derived mesenchymal stem cells promote skin wound healing with reduced scarring. Mater Sci Eng, C 27:181–188CrossRef
101.
Zurück zum Zitat Kim J et al (2013) Bioactive effects of graphene oxide cell culture substratum on structure and function of human adipose-derived stem cells. J Biomed Mater Res A 101:3520–3530CrossRef Kim J et al (2013) Bioactive effects of graphene oxide cell culture substratum on structure and function of human adipose-derived stem cells. J Biomed Mater Res A 101:3520–3530CrossRef
102.
Zurück zum Zitat Skoda M, Dudek D, Jarosz A, Szukiewicz D (2014) Graphene: one material, many possibilities—application difficulties in biological systems. J Nanomater 14, Art No. 890246 Skoda M, Dudek D, Jarosz A, Szukiewicz D (2014) Graphene: one material, many possibilities—application difficulties in biological systems. J Nanomater 14, Art No. 890246
103.
Zurück zum Zitat Dobrovolskaia MA, Germolec DR, Weaver JL (2009) Evaluation of nanoparticle immunotoxicity. Nat Nanotechnol 4:411–414CrossRef Dobrovolskaia MA, Germolec DR, Weaver JL (2009) Evaluation of nanoparticle immunotoxicity. Nat Nanotechnol 4:411–414CrossRef
104.
Zurück zum Zitat Pinto AM, Concalves IC, Magalhaes FD (2013) Graphene-based materials biocompatibility: a review. Colloids Surf Biointerfaces 111:188–202 Pinto AM, Concalves IC, Magalhaes FD (2013) Graphene-based materials biocompatibility: a review. Colloids Surf Biointerfaces 111:188–202
105.
Zurück zum Zitat Hu H, Yu J, Li Y, Zhao J, Dong H (2012) Engineering of a novel pluronic F127/graphene nanohybrid for pH responsive drug delivery. J Biomed Mater Res A 100(1):141–148 Hu H, Yu J, Li Y, Zhao J, Dong H (2012) Engineering of a novel pluronic F127/graphene nanohybrid for pH responsive drug delivery. J Biomed Mater Res A 100(1):141–148
106.
Zurück zum Zitat Yang Y, Zhang Y-M, Chen Y, Zhao D, Chen J-T, Liu y (2012) Construction of a graphene oxide based noncovalent multiple nanosupramolecular assembly as a scaffold for drug delivery. Chem. Eur J 18(14):4208–4215 Yang Y, Zhang Y-M, Chen Y, Zhao D, Chen J-T, Liu y (2012) Construction of a graphene oxide based noncovalent multiple nanosupramolecular assembly as a scaffold for drug delivery. Chem. Eur J 18(14):4208–4215
107.
Zurück zum Zitat Jin R, Ji X, Yang Y, Wang H and Cao A (2013) Self-assembled graphene–dextran nanohybrid for killing drug-resistant cancer cells. ACS Appl Mater Interfaces 5(15):7181–7189 Jin R, Ji X, Yang Y, Wang H and Cao A (2013) Self-assembled graphene–dextran nanohybrid for killing drug-resistant cancer cells. ACS Appl Mater Interfaces 5(15):7181–7189
108.
Zurück zum Zitat Song E, Han W, Li C, Cheng D, Li L, Liu L, Zhu G, Song Y, Tan W (2014) Hyaluronic acid-decorated graphene oxide nanohybrids as nanocarriers for targeted and pH-responsive anticancer drug delivery. ACS Appl Mater Interfaces 6(15):11882–11890 Song E, Han W, Li C, Cheng D, Li L, Liu L, Zhu G, Song Y, Tan W (2014) Hyaluronic acid-decorated graphene oxide nanohybrids as nanocarriers for targeted and pH-responsive anticancer drug delivery. ACS Appl Mater Interfaces 6(15):11882–11890
109.
Zurück zum Zitat Kim H, Lee D, Kim J, Kim TI, Kim WJ (2013) Photothermally triggered cytosolic drug delivery via endosome disruption using a functionalized reduced graphene oxide ACS Nano 7(8):6735–6746 Kim H, Lee D, Kim J, Kim TI, Kim WJ (2013) Photothermally triggered cytosolic drug delivery via endosome disruption using a functionalized reduced graphene oxide ACS Nano 7(8):6735–6746
110.
Zurück zum Zitat Shi J, Zhamg J, Ma R, Gao J, Liu Y, Zhang Ch, Zhang Z (2014) A tumor-targeting near-infrared laser-triggered drug delivery system based on GO@Ag nanoparticles for chemo-photothermal therapy and X-ray imaging. Biomaterials 35(22):5847–5861 Shi J, Zhamg J, Ma R, Gao J, Liu Y, Zhang Ch, Zhang Z (2014) A tumor-targeting near-infrared laser-triggered drug delivery system based on GO@Ag nanoparticles for chemo-photothermal therapy and X-ray imaging. Biomaterials 35(22):5847–5861
111.
Zurück zum Zitat Bai J, Liu Y, Jiang X (2014) Multifunctional PEG-GO/CuS nanocomposites for near-infrared chemo-photothermal therapy. Biomaterials 35(22):5805-5813 Bai J, Liu Y, Jiang X (2014) Multifunctional PEG-GO/CuS nanocomposites for near-infrared chemo-photothermal therapy. Biomaterials 35(22):5805-5813
112.
Zurück zum Zitat Wang C, Mallela J, Garapati US, Ravi S, Chinnasamy V, Girard Y, Howell M, Mohapatra S (2013) A chitosan-modified graphene nanogel for noninvasive controlled drug release. Nanomedicine 9(7):903–911 Wang C, Mallela J, Garapati US, Ravi S, Chinnasamy V, Girard Y, Howell M, Mohapatra S (2013) A chitosan-modified graphene nanogel for noninvasive controlled drug release. Nanomedicine 9(7):903–911
113.
Zurück zum Zitat Chen H, Wang Z, Zong S, Wu L, Chen P, Zhu D, Wang C, Xu S, Cui Y (2014) SERS-fluorescence monitored drug release of a redox-responsive nanocarrier based on graphene oxide in tumor cells. ACS Appl Mater Interfaces 6(20):17526–17533 Chen H, Wang Z, Zong S, Wu L, Chen P, Zhu D, Wang C, Xu S, Cui Y (2014) SERS-fluorescence monitored drug release of a redox-responsive nanocarrier based on graphene oxide in tumor cells. ACS Appl Mater Interfaces 6(20):17526–17533
114.
Zurück zum Zitat Zhao X, Liu L, Li X, Zeng J, Jia X, Liu P (2014) Biocompatible graphene oxide nanoparticle-based drug delivery platform for tumor microenvironment-responsive triggered release of doxorubicin. Langmuir 30(34):10419–10429 Zhao X, Liu L, Li X, Zeng J, Jia X, Liu P (2014) Biocompatible graphene oxide nanoparticle-based drug delivery platform for tumor microenvironment-responsive triggered release of doxorubicin. Langmuir 30(34):10419–10429
115.
Zurück zum Zitat He D, He X, Wang K, Zou Z, Yang X and Li X (2014) Remote-controlled drug release from graphene oxide-capped mesoporous silica to cancer cells by photoinduced pH-jump activation. Langmuir 30(24):7182–7189 He D, He X, Wang K, Zou Z, Yang X and Li X (2014) Remote-controlled drug release from graphene oxide-capped mesoporous silica to cancer cells by photoinduced pH-jump activation. Langmuir 30(24):7182–7189
116.
Zurück zum Zitat Wan H et al (2014) Facile fabrication of a near-infrared responsive nanocarrier for spatiotemporally controlled chemo-photothermal synergistic cancer therapy. Nanoscale 6:8743–8753 Wan H et al (2014) Facile fabrication of a near-infrared responsive nanocarrier for spatiotemporally controlled chemo-photothermal synergistic cancer therapy. Nanoscale 6:8743–8753
117.
Zurück zum Zitat Bian X et al (2014) Fabrication of graphene-isolated-Au-nanocrystal nanostructures for multimodal cell imaging and photothermal-enhanced chemotherapy. Sci Rep 4:6093 Bian X et al (2014) Fabrication of graphene-isolated-Au-nanocrystal nanostructures for multimodal cell imaging and photothermal-enhanced chemotherapy. Sci Rep 4:6093
118.
Zurück zum Zitat Miao W, Shim G, Kang CM, Lee S, Choe YS, Choi HG, Oh YK (2013) Cholesteryl hyaluronic acid-coated, reduced graphene oxide nanosheets for anti-cancer drug delivery. Biomaterials 34(37):9638–9647 Miao W, Shim G, Kang CM, Lee S, Choe YS, Choi HG, Oh YK (2013) Cholesteryl hyaluronic acid-coated, reduced graphene oxide nanosheets for anti-cancer drug delivery. Biomaterials 34(37):9638–9647
119.
Zurück zum Zitat Qin XC, Guo ZY, Liu ZM, Zhang W, Wan MM, Yang BW (2013) Folic acid-conjugated graphene oxide for cancer targeted chemo-photothermal therapy. J Photochem Photobiol B 120:156–162 Qin XC, Guo ZY, Liu ZM, Zhang W, Wan MM, Yang BW (2013) Folic acid-conjugated graphene oxide for cancer targeted chemo-photothermal therapy. J Photochem Photobiol B 120:156–162
120.
Zurück zum Zitat Zhang L, Xia J, Zhao Q, Liu L, Zhang Z (2010) Functional graphene oxide as a nanocarrier for controlled loading and targeted delivery of mixed anticancer drugs. Small 6(4):537–544 Zhang L, Xia J, Zhao Q, Liu L, Zhang Z (2010) Functional graphene oxide as a nanocarrier for controlled loading and targeted delivery of mixed anticancer drugs. Small 6(4):537–544
121.
Zurück zum Zitat Wei G, Yan M, Dong R, Wang D, Zhou X, Chen J, Hao J (2012) Covalent modification of reduced graphene oxide by means of diazonium chemistry and use as a drug-delivery system. Chemistry 18(46):14708–14716 Wei G, Yan M, Dong R, Wang D, Zhou X, Chen J, Hao J (2012) Covalent modification of reduced graphene oxide by means of diazonium chemistry and use as a drug-delivery system. Chemistry 18(46):14708–14716
122.
Zurück zum Zitat Wu J, Wang YS, Yang XY, Liu YY, Yang JR, Yang R, Zhang N (2012) Graphene oxide used as a carrier for adriamycin can reverse drug resistance in breast cancer cells. Nanotechnology 23(35):355101 Wu J, Wang YS, Yang XY, Liu YY, Yang JR, Yang R, Zhang N (2012) Graphene oxide used as a carrier for adriamycin can reverse drug resistance in breast cancer cells. Nanotechnology 23(35):355101
123.
Zurück zum Zitat Zhi F, Dong H, Jia X, Guo W, Lu H, Yang Y, Ju H, Zhang X, Hu Y (2013) Functionalized graphene oxide mediated adriamycin delivery and miR-21 gene silencing to overcome tumor multidrug resistance in vitro. PLoS One 8(3):e60034 Zhi F, Dong H, Jia X, Guo W, Lu H, Yang Y, Ju H, Zhang X, Hu Y (2013) Functionalized graphene oxide mediated adriamycin delivery and miR-21 gene silencing to overcome tumor multidrug resistance in vitro. PLoS One 8(3):e60034
124.
Zurück zum Zitat Zhang YM, Cao Y, Yang Y, Chen JT, Liu Y (2014) A small-sized graphene oxide supramolecular assembly for targeted delivery of camptothecin. Chem Commun (Camb) 50(86):13066–13069 Zhang YM, Cao Y, Yang Y, Chen JT, Liu Y (2014) A small-sized graphene oxide supramolecular assembly for targeted delivery of camptothecin. Chem Commun (Camb) 50(86):13066–13069
125.
Zurück zum Zitat Tian J, Luo Y, Huang L, Feng Y, Ju H, Yu BY (2016) Pegylated folate and peptide-decorated graphene oxide nanovehicle for in vivo targeted delivery of anticancer drugs and therapeutic self-monitoring. Biosens Bioelectron 80:519–524 Tian J, Luo Y, Huang L, Feng Y, Ju H, Yu BY (2016) Pegylated folate and peptide-decorated graphene oxide nanovehicle for in vivo targeted delivery of anticancer drugs and therapeutic self-monitoring. Biosens Bioelectron 80:519–524
126.
Zurück zum Zitat Xu Z, Wang S, Li Y, Wang M, Shi P, Huang X (2014) Covalent functionalization of graphene oxide with biocompatible poly (ethylene glycol) for delivery of paclitaxel. ACS Appl Mater Interfaces 6(19):17268–17276 Xu Z, Wang S, Li Y, Wang M, Shi P, Huang X (2014) Covalent functionalization of graphene oxide with biocompatible poly (ethylene glycol) for delivery of paclitaxel. ACS Appl Mater Interfaces 6(19):17268–17276
127.
Zurück zum Zitat Chaudhari NS et al (2014) Graphene oxide based magnetic nanocomposites for efficient treatment of breast cancer. Mater Sci Eng 37:278–285 Chaudhari NS et al (2014) Graphene oxide based magnetic nanocomposites for efficient treatment of breast cancer. Mater Sci Eng 37:278–285
128.
Zurück zum Zitat Saeed LM et al (2014) Single-walled carbon nanotube and graphene nanodelivery of gambogic acid increases its cytotoxicity in breast and pancreatic cancer cells. J Appl Toxicol 34(11):1188–1199 Saeed LM et al (2014) Single-walled carbon nanotube and graphene nanodelivery of gambogic acid increases its cytotoxicity in breast and pancreatic cancer cells. J Appl Toxicol 34(11):1188–1199
129.
Zurück zum Zitat Kakran M, Sahoo NG, Bao H, Pan Y, Li L (2011) Functionalized graphene oxide as nanocarrier for loading and delivery of ellagic Acid. Curr Med Chem 18(29):4503–4512 Kakran M, Sahoo NG, Bao H, Pan Y, Li L (2011) Functionalized graphene oxide as nanocarrier for loading and delivery of ellagic Acid. Curr Med Chem 18(29):4503–4512
130.
Zurück zum Zitat Some S et al (2014) Cancer therapy using ultrahigh hydrophobic drug-loaded graphene derivatives. Scientif Rep 4, Art No. 6314 Some S et al (2014) Cancer therapy using ultrahigh hydrophobic drug-loaded graphene derivatives. Scientif Rep 4, Art No. 6314
131.
Zurück zum Zitat Maity AR, Chakraborty A, Mondal A, Jana NR (2014) Carbohydrate coated, folate functionalized colloidal graphene as a nanocarrier for both hydrophobic and hydrophilic drugs. Nanoscale 6(5):2752–2758 Maity AR, Chakraborty A, Mondal A, Jana NR (2014) Carbohydrate coated, folate functionalized colloidal graphene as a nanocarrier for both hydrophobic and hydrophilic drugs. Nanoscale 6(5):2752–2758
132.
Zurück zum Zitat Misra SK, Kondaiah P, Bhattacharya S, Rao CNR (2012) Graphene as a nanocarrier for tamoxifen induces apoptosis in transformed cancer cell lines of different origins. Small 8:131–143 Misra SK, Kondaiah P, Bhattacharya S, Rao CNR (2012) Graphene as a nanocarrier for tamoxifen induces apoptosis in transformed cancer cell lines of different origins. Small 8:131–143
133.
Zurück zum Zitat Zheng XT, Li CM (2012) Restoring basal planes of graphene oxides for highly efficient loading and delivery of β-lapachone. Mol Pharm 9(3):615–621 Zheng XT, Li CM (2012) Restoring basal planes of graphene oxides for highly efficient loading and delivery of β-lapachone. Mol Pharm 9(3):615–621
134.
Zurück zum Zitat Fan X, Jiao G, Zhao W, Jin P, Li X (2013) Magnetic Fe3O4-graphene composites as targeted drug nanocarriers for pH-activated release. Nanoscale 5(3):1143–1152 Fan X, Jiao G, Zhao W, Jin P, Li X (2013) Magnetic Fe3O4-graphene composites as targeted drug nanocarriers for pH-activated release. Nanoscale 5(3):1143–1152
135.
Zurück zum Zitat Lu Y-J et al (2012) Improving thermal stability and efficacy of BCNU in treating glioma cells using PAA-functionalized graphene oxide. Int J Nanomed 7: 1737–1747 Lu Y-J et al (2012) Improving thermal stability and efficacy of BCNU in treating glioma cells using PAA-functionalized graphene oxide. Int J Nanomed 7: 1737–1747
136.
Zurück zum Zitat Chen GY et al (2015) Graphene oxide as a chemosensitizer: diverted autophagic flux, enhanced nuclear import, elevated necrosis and improved antitumor effects. Biomaterials 40:12–22 Chen GY et al (2015) Graphene oxide as a chemosensitizer: diverted autophagic flux, enhanced nuclear import, elevated necrosis and improved antitumor effects. Biomaterials 40:12–22
137.
Zurück zum Zitat Hou L et al (2016) Multifunctional hyaluronic acid modified graphene oxide loaded with mitoxantrone for overcoming drug resistance in cancer. Nanotechnology 27(1):015701 Hou L et al (2016) Multifunctional hyaluronic acid modified graphene oxide loaded with mitoxantrone for overcoming drug resistance in cancer. Nanotechnology 27(1):015701
138.
Zurück zum Zitat Kim H, Namgung R, Singha K, Oh IK, Kim WJ (2011) Graphene oxide-polyethylenimine nanoconstruct as a gene delivery vector and bioimaging tool. Bioconjug Chem 22(12):2558–2567 Kim H, Namgung R, Singha K, Oh IK, Kim WJ (2011) Graphene oxide-polyethylenimine nanoconstruct as a gene delivery vector and bioimaging tool. Bioconjug Chem 22(12):2558–2567
139.
Zurück zum Zitat Zhi F, Dong H, Jia X, Guo W, Lu H, Yang Y et al (2013) Functionalized graphene oxide mediated adriamycin delivery and miR-21 gene silencing to overcome tumor multidrug resistance in vitro. PLoS ONE 8(3):e60034 Zhi F, Dong H, Jia X, Guo W, Lu H, Yang Y et al (2013) Functionalized graphene oxide mediated adriamycin delivery and miR-21 gene silencing to overcome tumor multidrug resistance in vitro. PLoS ONE 8(3):e60034
140.
Zurück zum Zitat Wang F, Zhang B, Zhou L, Shi Y, Li Z, Xia Y, Tian J (2016) Imaging dendrimer-grafted graphene oxide mediated anti-miR-21 delivery with an activatable luciferase reporter. ACS Appl Mater Interfaces 8(14):9014–9021 Wang F, Zhang B, Zhou L, Shi Y, Li Z, Xia Y, Tian J (2016) Imaging dendrimer-grafted graphene oxide mediated anti-miR-21 delivery with an activatable luciferase reporter. ACS Appl Mater Interfaces 8(14):9014–9021
141.
Zurück zum Zitat Feng L, Zhang S and Liu Z (2011) Graphene based gene transfection. Nanoscale 3:1252–1257 Feng L, Zhang S and Liu Z (2011) Graphene based gene transfection. Nanoscale 3:1252–1257
142.
Zurück zum Zitat Zhang L, Lu Z, Zhao Q, Huang J, Shen H, Zhang Z (2011) Enhanced chemotherapy efficacy by sequential delivery of siRNA and anticancer drugs using PEI-grafted graphene oxide. Small 7(4):460–464 Zhang L, Lu Z, Zhao Q, Huang J, Shen H, Zhang Z (2011) Enhanced chemotherapy efficacy by sequential delivery of siRNA and anticancer drugs using PEI-grafted graphene oxide. Small 7(4):460–464
143.
Zurück zum Zitat Chen B, Liu M, Zhang L, Huang J, Yao J, Zhang Z (2011) Polyethylenimine-functionalized graphene oxide as an efficient gene delivery vector. J Mater Chem 21:7736–7741 Chen B, Liu M, Zhang L, Huang J, Yao J, Zhang Z (2011) Polyethylenimine-functionalized graphene oxide as an efficient gene delivery vector. J Mater Chem 21:7736–7741
144.
Zurück zum Zitat Wang Ch et al (2013) Multifunctional chitosan magnetic-graphene (CMG) nanoparticles: a theranostic platform for tumor-targeted co-delivery of drugs, genes and MRI contrast agents. J Mater Chem B 1:4396–4405 Wang Ch et al (2013) Multifunctional chitosan magnetic-graphene (CMG) nanoparticles: a theranostic platform for tumor-targeted co-delivery of drugs, genes and MRI contrast agents. J Mater Chem B 1:4396–4405
Metadaten
Titel
Potential and Challenges of Graphene in Medicine
verfasst von
Marta Skoda
Ilona Dudek
Dariusz Szukiewicz
Copyright-Jahr
2016
DOI
https://doi.org/10.1007/978-3-319-45639-3_1

    Marktübersichten

    Die im Laufe eines Jahres in der „adhäsion“ veröffentlichten Marktübersichten helfen Anwendern verschiedenster Branchen, sich einen gezielten Überblick über Lieferantenangebote zu verschaffen.