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Journal of Polymer Research
Erschienen in: Journal of Polymer Research 3/2021

01.03.2021 | ORIGINAL PAPER

Preparation of floating polymer-valsartan delivery systems using supercritical CO2

verfasst von: Stoja Milovanovic, Jelena Djuris, Aleksandra Dapčević, Marija Lucic Skoric, Djordje Medarevic, Stefan M. Pavlović, Svetlana Ibric

Erschienen in: Journal of Polymer Research | Ausgabe 3/2021

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Abstract

This study investigates pharmaceutical polymers (Soluplus®, HPMCAS, and Eudragit® E100) and supercritical CO2-assisted process for preparation of floating valsartan delivery systems. Tested process (at pressure of 30 MPa and temperature of 100 °C during 2 h) enabled preparation of stable porous valsartan formulations which was confirmed with FESEM and mercury intrusion porosimetry analysis. The bulk density of obtained formulations was lower than 550 kg/m3. FTIR, DSC, and PXRD analysis indicated that there was no chemical interaction between the drug and polymers and that amorphous solid dispersions were obtained. Formulations with Soluplus® and HPMCAS retained its buoyancy in 0.1 M HCl for longer than 24 h, while formulation with Eudragit® E100 retained its buoyancy up to 2 h. Controlled valsartan release was influenced by solubility of polymers in the tested release medium, which was confirmed by UV/VIS spectroscopy. The obtained results provided framework for further development of floating drug delivery system using an environmental friendly process.
Vorheriger Artikel Fabrication, morphological, structural and electrochemical characterization of sulfonated polyimide/clay-based hybrid nanocomposite membranes for energy application
Nächster Artikel An image-based approach for structure investigation and 3D numerical modelling of polymeric foams

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Metadaten
Titel
Preparation of floating polymer-valsartan delivery systems using supercritical CO2
verfasst von
Stoja Milovanovic
Jelena Djuris
Aleksandra Dapčević
Marija Lucic Skoric
Djordje Medarevic
Stefan M. Pavlović
Svetlana Ibric
Publikationsdatum
01.03.2021
Verlag
Springer Netherlands
Erschienen in
Journal of Polymer Research / Ausgabe 3/2021
Print ISSN: 1022-9760
Elektronische ISSN: 1572-8935
DOI
https://doi.org/10.1007/s10965-021-02440-1

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