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1987 | OriginalPaper | Buchkapitel

Production and Characterization of Monoclonal Antibodies to Thiol-Modified Glutathione

verfasst von : Joseph P. Messina, Joseph Mazurkiewicz, David A. Lawrence

Erschienen in: Anticarcinogenesis and Radiation Protection

Verlag: Springer US

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Glutathione (GSH), a multifunctional tripeptide thiol found in virtually all mammalian cells, has a prominent role in the maintenance and execution of many homeostatic and regulatory processes of the cell (1). Of the many functions of GSH, perhaps the most studied, is its ability to protect the cell against the detrimental effects of ionizing radiation, reactive oxygen compounds, free radicals, and toxic xenobiotics (2). The GSH oxidation-reduction cycle is of primary importance when dealing with reactive oxygen intermediates as well as the detoxification of xenobiotics. Although the elimination of each is catalyzed by different enzymes, GSH peroxidase in the former and GSH S-transferases in the latter, the maintenance of a high ratio of GSH:GSSG by the cycle is of vital importance to both pathways.

Metadaten
Titel
Production and Characterization of Monoclonal Antibodies to Thiol-Modified Glutathione
verfasst von
Joseph P. Messina
Joseph Mazurkiewicz
David A. Lawrence
Copyright-Jahr
1987
Verlag
Springer US
DOI
https://doi.org/10.1007/978-1-4615-6462-1_61