nach oben

Erschienen in:

2023 | OriginalPaper | Buchkapitel

Protective Effects of Resveratrol on Brain Edema and Microstructural Changes in Human Brain After Acute Alcohol Intake: Assessment by Diffusion Weighted Kurtosis Imaging

verfasst von : Gengbiao Zhang, Yingju Lu, Hongyi Zheng, Lingmei Kong, Wenbin Zheng

Erschienen in: Biomedical and Computational Biology

Verlag: Springer International Publishing

Einloggen

Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.

search-config

KI-gestützte Suche

Aus

Abstract

Resveratrol can initiate anti-alcoholic functions in the human body. Magnetic resonance diffusion kurtosis imaging (DKI) can comprehensively evaluate ethanol associated brain changes at different time points. This study aimed at utilizing the DKI technique to evaluate the protective effects of resveratrol on brain. Ten volunteers were recruited into this study. Participants in Group A were orally administered with a high alcoholic dose. Those in Group R only took resveratrol, and each participant in Group AR received resveratrol before taking alcohol with the same dose in Group A. Each group included the same 10 volunteers. Each volunteer was subjected to 3 batches of DKI tests. DKI data and images were obtained before drinking, 1.5 h after drinking and at 2 h after drinking. The data obtained before drinking were set as the control group, and the rest data were compared with it. Both Group A and Group AR showed the decrease of mean diffusion (MD) values in multiple brain regions (Group A, n = 12; Group AR, n = 3), Group A showed increased fractional anisotropy (FA) values (n = 16) and Group AR showed increased mean kurtosis (MK) values (n = 7) in multiple brain regions. The MK values of Group A and FA values of Group AR showed biphasic changes in different brain regions. Comparisons between Group A and Group AR, Group AR showed lower FA values in 9 brain regions. The results implied that alcohol caused less damage to the brains of the AR group. DKI can be used to quantify changes in brain tissue microstructure during acute alcohol exposure. The ability of resveratrol consumption to mitigate fluctuations in DKI parameters associated with acute alcohol intake suggests that resveratrol has a protective effect on the brain in a state of alcohol exposure.

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

über 102.000 Bücher
über 537 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Finance + Banking
Management + Führung
Marketing + Vertrieb
Maschinenbau + Werkstoffe
Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Jetzt informieren

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

über 67.000 Bücher
über 390 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Maschinenbau + Werkstoffe

Jetzt Wissensvorsprung sichern!

Jetzt informieren

Springer Professional "Wirtschaft"

Online-Abonnement

Mit Springer Professional "Wirtschaft" erhalten Sie Zugriff auf:

über 67.000 Bücher
über 340 Zeitschriften

aus folgenden Fachgebieten:

Bauwesen + Immobilien
Business IT + Informatik
Finance + Banking
Management + Führung
Marketing + Vertrieb
Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Jetzt informieren

Vorheriges Kapitel Screening of Key Genes in Retinoblastoma and Construction of ceRNA Regulatory Network

Nächstes Kapitel Effects of Music Style on Mental Fatigue Induced by Continuous Cognitive Tasks

Topiwala, A., Allan, C.L., Valkanova, V., et al.: Moderate alcohol consumption as risk factor for adverse brain outcomes and cognitive decline: longitudinal cohort study. BMJ (Clin. Res. Ed.) 357, j2353 (2017). https://doi.org/10.1136/bmj.j2353

Geneva: World Health Organization: Global status report on alcohol and health 2018: executive summary. (WHO/ MSD/MSB/18.2). Licence: CC BY-NC-SA 3.0 IGO (2018)

Fritz, M., Klawonn, A.M., Zahr, N.M.: Neuroimaging in alcohol use disorder: from mouse to man. J. Neurosci. Res. 100(5), 1140–1158 (2022). https://doi.org/10.1002/jnr.24423CrossRefPubMed

Takahashi, N., Senda, M., Lin, S., et al.: Auraptene regulates gene expression involved in lipid metabolism through PPARα activation in diabetic obese mice. Mol. Nutr. Food Res. 55(12), 1791–1797 (2011). https://doi.org/10.1002/mnfr.201100401CrossRefPubMed

Kidani, Y., Bensinger, S.J.: Liver X receptor and peroxisome proliferator-activated receptor as integrators of lipid homeostasis and immunity. Immunol. Rev. 249(1), 72–83 (2012). https://doi.org/10.1111/j.1600-065X.2012.01153.xCrossRefPubMedPubMedCentral

Berger, J., Moller, D.E.: The mechanisms of action of PPARs. Annu. Rev. Med. 53, 409–435 (2002). https://doi.org/10.1146/annurev.med.53.082901.104018CrossRefPubMed

Jonker, J.W., Suh, J.M., Atkins, A.R., et al.: A PPARγ-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis. Nature 485(7398), 391–394 (2012). https://doi.org/10.1038/nature10998CrossRefPubMedPubMedCentral

Huang, J., Jia, Y., Fu, T., et al.: Sustained activation of PPARα by endogenous ligands increases hepatic fatty acid oxidation and prevents obesity in ob/ob mice. FASEB J. Official Publ. Fed. Am. Soc. Exp. Biol. 26(2), 628–638 (2012). https://doi.org/10.1096/fj.11-194019CrossRef

Kong, L.M., Zheng, W.B., Lian, G.P., et al.: Acute effects of alcohol on the human brain: diffusion tensor imaging study. AJNR Am. J. Neuroradiol. 33(5), 928–934 (2012). https://doi.org/10.3174/ajnr.A2873CrossRefPubMedPubMedCentral

10.

Chen, X.R., Zeng, J.Y., Shen, Z.W., et al.: Diffusion kurtosis imaging detects microstructural changes in the brain after acute alcohol intoxication in rats. Biomed. Res. Int. 2017, 4757025 (2017). https://doi.org/10.1155/2017/4757025CrossRefPubMedPubMedCentral

11.

Liu, H.M.: A study of acute EtOH intoxication on the brain of rat using 7.0T DWI and 1H-MRS. Medical College of Shantou University (2013)

12.

Kong, L., Lian, G., Zheng, W., et al.: Effect of alcohol on diffuse axonal injury in rat brainstem: diffusion tensor imaging and aquaporin-4 expression study. Biomed. Res. Int. 2013, 798261 (2013). https://doi.org/10.1155/2013/798261CrossRefPubMedPubMedCentral

13.

Yamakami, I., Vink, R., Faden, A.I., et al.: Effects of acute ethanol intoxication on experimental brain injury in the rat: neurobehavioral and phosphorus-31 nuclear magnetic resonance spectroscopy studies. J. Neurosurg. 82(5), 813–821 (1995). https://doi.org/10.3171/jns.1995.82.5.0813CrossRefPubMed

14.

Lu, Y., Gao, G.S., Yu, X.J., et al.: Effects of ethanol on Ngb, Hif-1α and Na+, K+ -ATPase activity of brain and mechanism of death. 23(2), 96–99 (2009)

15.

McDonough, K.H., Giaimo, M.E., Miller, H.I., et al.: Low-dose ethanol alters the cardiovascular, metabolic, and respiratory compensation for severe blood loss. J. Trauma 53(3), 541–548 (2002). https://doi.org/10.1097/00005373-200209000-00024

16.

Matés, J.M., Pérez-Gómez, C., Núñez de Castro, I.: Antioxidant enzymes and human diseases. Clin. Biochem. 32(8), 595–603 (1999). https://doi.org/10.1016/s0009-9120(99)00075-2

17.

Yoo, H.Y., Chang, M.S., Rho, H.M.: Induction of the rat Cu/Zn superoxide dismutase gene through the peroxisome proliferator-responsive element by arachidonic acid. Gene 234(1), 87–91 (1999). https://doi.org/10.1016/s0378-1119(99)00176-6CrossRefPubMed

18.

Chen, C.C., Yin, S.J.: Alcohol abuse and related factors in Asia. Int. Rev. Psychiatry (Abingdon, England) 20(5), 425–433 (2008). https://doi.org/10.1080/09540260802344075CrossRef

19.

Karadayian, A.G., Bustamante, J., Czerniczyniec, A., et al.: Alcohol hangover induces mitochondrial dysfunction and free radical production in mouse cerebellum. Neuroscience 304, 47–59 (2015). https://doi.org/10.1016/j.neuroscience.2015.07.012CrossRefPubMed

20.

Koch, O.R., Pani, G., Borrello, S., et al.: Oxidative stress and antioxidant defenses in ethanol-induced cell injury. Mol. Aspects Med. 25(1–2), 191–198 (2004). https://doi.org/10.1016/j.mam.2004.02.019CrossRefPubMed

21.

Snopek, L., Mlcek, J., Sochorova, L., et al.: Contribution of red wine consumption to human health protection. Molecules (Basel, Switzerland) 23(7) (2018). https://doi.org/10.3390/molecules23071684

22.

Petrella, C., Carito, V., Carere, C., et al.: Oxidative stress inhibition by resveratrol in alcohol-dependent mice. Nutrition (Burbank, Los Angeles County, Calif) 79–80, 110783 (2020). https://doi.org/10.1016/j.nut.2020.110783

23.

Van Cauter, S., Veraart, J., Sijbers, J., et al.: Gliomas: diffusion kurtosis MR imaging in grading. Radiology 263(2), 492–501 (2012). https://doi.org/10.1148/radiol.12110927CrossRefPubMed

24.

Cernak, I., Vink, R., Zapple, D.N., et al.: The pathobiology of moderate diffuse traumatic brain injury as identified using a new experimental model of injury in rats. Neurobiol. Dis. 17(1), 29–43 (2004). https://doi.org/10.1016/j.nbd.2004.05.011CrossRefPubMed

Titel: Protective Effects of Resveratrol on Brain Edema and Microstructural Changes in Human Brain After Acute Alcohol Intake: Assessment by Diffusion Weighted Kurtosis Imaging
verfasst von: Gengbiao Zhang
Yingju Lu
Hongyi Zheng
Lingmei Kong
Wenbin Zheng
Verlag: Springer International Publishing
Buch: Biomedical and Computational Biology
Print ISBN: 978-3-031-25190-0

Electronic ISBN: 978-3-031-25191-7

Copyright-Jahr: 2023
DOI: https://doi.org/10.1007/978-3-031-25191-7_13

Springer Professional

Abstract

Bitte loggen Sie sich ein, um Zugang zu Ihrer Lizenz zu erhalten.

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Springer Professional "Technik"

Springer Professional "Wirtschaft"

Premium Partner