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2015 | OriginalPaper | Buchkapitel

Analysis of microRNA Microarrays in Cardiogenesis

verfasst von : Diego Franco, Fernando Bonet, Francisco Hernandez-Torres, Estefania Lozano-Velasco, Francisco J. Esteban, Amelia E. Aranega

Verlag: Springer New York

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Abstract

microRNAs are a subclass of noncoding RNAs which have been demonstrated to play pivotal roles in multiple cellular mechanisms. microRNAs are small RNA molecules of 22–24 nt in length capable of modulating protein translation and/or RNA stability by base-priming with complementary sequences of the mRNAs, normally at the 3′untranslated region. To date, over 2,000 microRNAs have been already identified in humans, and orthologous microRNAs have been also identified in distinct animals and plants ranging a wide vast of species. High-throughput analyses by microarrays have become a gold standard to analyze the changes on microRNA expression in normal and pathological cellular or tissue conditions. In this chapter, we provide insights into the usage of this uprising technology in the context of cardiac development and disease.
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Metadaten
Titel
Analysis of microRNA Microarrays in Cardiogenesis
verfasst von
Diego Franco
Fernando Bonet
Francisco Hernandez-Torres
Estefania Lozano-Velasco
Francisco J. Esteban
Amelia E. Aranega
Copyright-Jahr
2015
Verlag
Springer New York
DOI
https://doi.org/10.1007/7651_2015_247