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Erschienen in: Medical & Biological Engineering & Computing 4/2008

01.04.2008 | Original Article

Radial basis function classifiers to help in the diagnosis of the obstructive sleep apnoea syndrome from nocturnal oximetry

verfasst von: J. Víctor Marcos, Roberto Hornero, Daniel Álvarez, Félix del Campo, Miguel López, Carlos Zamarrón

Erschienen in: Medical & Biological Engineering & Computing | Ausgabe 4/2008

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Abstract

The aim of this study is to assess the ability of radial basis function (RBF) classifiers as an assistant tool for the diagnosis of the obstructive sleep apnoea syndrome (OSAS). A total of 187 subjects suspected of suffering from OSAS were available for our research. The initial population was divided into training, validation and test sets for deriving and testing our neural classifiers. We used nonlinear features from nocturnal oxygen saturation (SaO2) to perform patients’ classification. We evaluated three different RBF construction techniques based on the following algorithms: k-means (KM), fuzzy c-means (FCM) and orthogonal least squares (OLS). A diagnostic accuracy of 86.1, 84.7 and 85.5% was provided by the networks developed with KM, FCM and OLS, respectively. The three proposed networks achieved an area under the receiver operating characteristic (ROC) curve over 0.90. Our results showed that a useful non-invasive method could be applied to diagnose OSAS from nonlinear features of SaO2 with RBF classifiers.

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Literatur
1.
Zurück zum Zitat Aboy M, Hornero R, Abásolo D et al (2006) Interpretation of the Lempel-Ziv complexity measure in the context of biomedical signal analysis. IEEE Trans Biomed Eng 53:2282–2288CrossRef Aboy M, Hornero R, Abásolo D et al (2006) Interpretation of the Lempel-Ziv complexity measure in the context of biomedical signal analysis. IEEE Trans Biomed Eng 53:2282–2288CrossRef
2.
Zurück zum Zitat Álvarez D, Hornero R, Abásolo D et al (2006) Nonlinear characteristics of blood oxygen saturation from nocturnal oximetry for obstructive sleep apnoea detection. Physiol Meas 27:399–412CrossRef Álvarez D, Hornero R, Abásolo D et al (2006) Nonlinear characteristics of blood oxygen saturation from nocturnal oximetry for obstructive sleep apnoea detection. Physiol Meas 27:399–412CrossRef
3.
Zurück zum Zitat Basheer IA, Hajmeer M (2000) Artificial neural networks: fundamentals, computing, design, and application. J Microbiol Methods 43:3–31CrossRef Basheer IA, Hajmeer M (2000) Artificial neural networks: fundamentals, computing, design, and application. J Microbiol Methods 43:3–31CrossRef
4.
Zurück zum Zitat Baxt WG (1995) Application of artificial neural networks to clinical medicine. Lancet 346:1135–1138CrossRef Baxt WG (1995) Application of artificial neural networks to clinical medicine. Lancet 346:1135–1138CrossRef
5.
Zurück zum Zitat Bezdek JC (1981) Pattern recognition with fuzzy objective function algorithms. Plenum Press, New YorkMATH Bezdek JC (1981) Pattern recognition with fuzzy objective function algorithms. Plenum Press, New YorkMATH
6.
Zurück zum Zitat Bishop CM (1995) Neural networks for pattern recognition. Oxford University Press, Oxford Bishop CM (1995) Neural networks for pattern recognition. Oxford University Press, Oxford
7.
8.
Zurück zum Zitat Bloch KE (2003) Getting the most out of nocturnal pulse oximetry. Chest 124:1628–1630CrossRef Bloch KE (2003) Getting the most out of nocturnal pulse oximetry. Chest 124:1628–1630CrossRef
9.
Zurück zum Zitat Burioka N, Cornélissen G, Halberg F et al (2003) Approximate entropy of human respiratory movement during eye-closed waking and different sleep stages. Chest 123:80–86CrossRef Burioka N, Cornélissen G, Halberg F et al (2003) Approximate entropy of human respiratory movement during eye-closed waking and different sleep stages. Chest 123:80–86CrossRef
10.
Zurück zum Zitat Caldirola D, Bellodi L, Caumo A et al (2004) Approximate entropy of respiratory patterns in panic disorder. Am J Psychiatr 161:79–87CrossRef Caldirola D, Bellodi L, Caumo A et al (2004) Approximate entropy of respiratory patterns in panic disorder. Am J Psychiatr 161:79–87CrossRef
11.
Zurück zum Zitat Catelani M, Fort A (2000) Fault diagnosis of electronic analog circuits using a radial basis function network classifier. Measurement 28:147–158CrossRef Catelani M, Fort A (2000) Fault diagnosis of electronic analog circuits using a radial basis function network classifier. Measurement 28:147–158CrossRef
12.
Zurück zum Zitat Chen S, Cowan CFN, Grant PM (1991) Orthogonal least squares learning algorithm for radial basis function networks. IEEE Trans Neural Netw 2:302–309CrossRef Chen S, Cowan CFN, Grant PM (1991) Orthogonal least squares learning algorithm for radial basis function networks. IEEE Trans Neural Netw 2:302–309CrossRef
13.
Zurück zum Zitat Cohen ME, Hudson DL, Deedwania PC (1996) Applying continuous chaotic modeling to cardiac signals. IEEE Eng Med Biol Mag 15:97–102CrossRef Cohen ME, Hudson DL, Deedwania PC (1996) Applying continuous chaotic modeling to cardiac signals. IEEE Eng Med Biol Mag 15:97–102CrossRef
14.
Zurück zum Zitat Cohen ME, Hudson DL (2000) New chaotic methods for biomedical signal analysis. In: Proceedings of the IEEE EMBS international conference on information technology applications in biomedicine, pp 123–128 Cohen ME, Hudson DL (2000) New chaotic methods for biomedical signal analysis. In: Proceedings of the IEEE EMBS international conference on information technology applications in biomedicine, pp 123–128
15.
Zurück zum Zitat El-Solh AA, Mador MJ, Ten-Brock E et al (1999) Validity of neural network in sleep apnea. Sleep 22:105–111 El-Solh AA, Mador MJ, Ten-Brock E et al (1999) Validity of neural network in sleep apnea. Sleep 22:105–111
16.
Zurück zum Zitat Er MJ, Chen W, Wu S (2005) High-speed face recognition based on discrete cosine transform and RBF neural networks. IEEE Trans Neural Netw 16:679–691CrossRef Er MJ, Chen W, Wu S (2005) High-speed face recognition based on discrete cosine transform and RBF neural networks. IEEE Trans Neural Netw 16:679–691CrossRef
17.
Zurück zum Zitat Folland R, Hines EL, Boilot P et al (2002) Classifying coronary dysfunction using neural networks through cardiovascular auscultation. Med Biol Eng Comput 40:339–343CrossRef Folland R, Hines EL, Boilot P et al (2002) Classifying coronary dysfunction using neural networks through cardiovascular auscultation. Med Biol Eng Comput 40:339–343CrossRef
18.
Zurück zum Zitat Goldberger AL, Peng CK, Lipsitz LA (2002) What is physiologic complexity and how does it change with aging and disease? Neurobiol Aging 23:23–26CrossRef Goldberger AL, Peng CK, Lipsitz LA (2002) What is physiologic complexity and how does it change with aging and disease? Neurobiol Aging 23:23–26CrossRef
19.
Zurück zum Zitat Hanley JA, McNeil BJ (1982) The meaning and use of the area under a receiving operating characteristic (ROC) curve. Radiology 143:29–36 Hanley JA, McNeil BJ (1982) The meaning and use of the area under a receiving operating characteristic (ROC) curve. Radiology 143:29–36
20.
Zurück zum Zitat Hanley JA, McNeil BJ (1983) A method of comparing the areas under receiver operating characteristic curves derived from the same case. Radiology 148:839–843 Hanley JA, McNeil BJ (1983) A method of comparing the areas under receiver operating characteristic curves derived from the same case. Radiology 148:839–843
21.
Zurück zum Zitat Haykin S (1999) Neural networks: a comprehensive foundation. Prentice-Hall, Englewood CliffsMATH Haykin S (1999) Neural networks: a comprehensive foundation. Prentice-Hall, Englewood CliffsMATH
22.
Zurück zum Zitat Hornero R, Abásolo D, Aboy M et al (2005) Interpretation of approximate entropy: analysis of intracranial pressure approximate entropy during acute intracranial hypertension. IEEE Trans Biomed Eng 52:1671–1680CrossRef Hornero R, Abásolo D, Aboy M et al (2005) Interpretation of approximate entropy: analysis of intracranial pressure approximate entropy during acute intracranial hypertension. IEEE Trans Biomed Eng 52:1671–1680CrossRef
23.
Zurück zum Zitat Hornero R, Álvarez D, Abásolo D et al (2007) Utility of approximate entropy from overnight pulse oximetry data in the diagnosis of the obstructive sep apnea syndrome. IEEE Trans Biomed Eng 54:107–113CrossRef Hornero R, Álvarez D, Abásolo D et al (2007) Utility of approximate entropy from overnight pulse oximetry data in the diagnosis of the obstructive sep apnea syndrome. IEEE Trans Biomed Eng 54:107–113CrossRef
24.
Zurück zum Zitat Hush DR, Horne BG (1993) Progress in supervised neural networks. IEEE Signal Process Mag 10:8–39CrossRef Hush DR, Horne BG (1993) Progress in supervised neural networks. IEEE Signal Process Mag 10:8–39CrossRef
25.
Zurück zum Zitat Jain AK, Murty MN, Flynn PJ (1999) Data clustering: a review. ACM Comput Surv 31:264–323CrossRef Jain AK, Murty MN, Flynn PJ (1999) Data clustering: a review. ACM Comput Surv 31:264–323CrossRef
26.
Zurück zum Zitat Jureyda S, Shucard DW (2004) Obstructive sleep apnea: an overview of the disorder and its consequences. Semin Orthod 10:63–72CrossRef Jureyda S, Shucard DW (2004) Obstructive sleep apnea: an overview of the disorder and its consequences. Semin Orthod 10:63–72CrossRef
27.
Zurück zum Zitat Kirby SD, Danter W, George CFP et al (1999) Neural network prediction of obstructive sleep apnea from clinical criteria. Chest 116:409–415CrossRef Kirby SD, Danter W, George CFP et al (1999) Neural network prediction of obstructive sleep apnea from clinical criteria. Chest 116:409–415CrossRef
29.
Zurück zum Zitat Leonard JA, Kramer MA (1991) Radial basis function networks for classifying process faults. IEEE Control Syst Mag 11:31–38CrossRef Leonard JA, Kramer MA (1991) Radial basis function networks for classifying process faults. IEEE Control Syst Mag 11:31–38CrossRef
30.
Zurück zum Zitat Magalang UJ, Dmochowski J, Veeramachaneni S et al (2003) Prediction of the apnea-hypopnea index from overnight pulse oximetry. Chest 124:1694–1701CrossRef Magalang UJ, Dmochowski J, Veeramachaneni S et al (2003) Prediction of the apnea-hypopnea index from overnight pulse oximetry. Chest 124:1694–1701CrossRef
31.
Zurück zum Zitat Moller MF (1993) A scaled conjugate gradient algorithm for fast supervised learning. Neural Netw 6:525–533CrossRef Moller MF (1993) A scaled conjugate gradient algorithm for fast supervised learning. Neural Netw 6:525–533CrossRef
32.
Zurück zum Zitat Netzer N, Eliasson AH, Netzer C et al (2001) Overnight pulse oximetry for sleep-disordered-breathing in adults: a review. Chest 120:625–633CrossRef Netzer N, Eliasson AH, Netzer C et al (2001) Overnight pulse oximetry for sleep-disordered-breathing in adults: a review. Chest 120:625–633CrossRef
33.
Zurück zum Zitat Pincus SM (2001) Assessing serial irregularity and its implications for health. Ann N Y Acad Sci 954:245–267CrossRef Pincus SM (2001) Assessing serial irregularity and its implications for health. Ann N Y Acad Sci 954:245–267CrossRef
34.
Zurück zum Zitat Rechtschaffen A, Kales A (1968) A manual of standardized terminology, techniques and scoring system for sleep stages of human subjects. Brain information services, Brain research institute, University of California, Los Angeles Rechtschaffen A, Kales A (1968) A manual of standardized terminology, techniques and scoring system for sleep stages of human subjects. Brain information services, Brain research institute, University of California, Los Angeles
35.
Zurück zum Zitat Roche N, Herer B, Roig C et al (2002) Prospective testing of two models based on clinical and oximetric variables for prediction of obstructive sleep apnea. Chest 121:747–752CrossRef Roche N, Herer B, Roig C et al (2002) Prospective testing of two models based on clinical and oximetric variables for prediction of obstructive sleep apnea. Chest 121:747–752CrossRef
36.
Zurück zum Zitat Schlosshan D, Elliot MW (2004) Sleep 3: clinical presentation and diagnosis of the obstructive sleep apnoea hypopnoea syndrome. Thorax 59:347–352CrossRef Schlosshan D, Elliot MW (2004) Sleep 3: clinical presentation and diagnosis of the obstructive sleep apnoea hypopnoea syndrome. Thorax 59:347–352CrossRef
37.
Zurück zum Zitat The Atlas Task Force (1992) EEG arousals: scoring rules and examples. A preliminary report from the Sleep Disorder Task Force of the American Sleep Disorders Association. Sleep 15:173–184 The Atlas Task Force (1992) EEG arousals: scoring rules and examples. A preliminary report from the Sleep Disorder Task Force of the American Sleep Disorders Association. Sleep 15:173–184
38.
Zurück zum Zitat Van Houwelingen KG, Van Uffelen R, Van Vliet ACM (1999) The sleep apnoea syndromes. Eur Heart J 20:858–866CrossRef Van Houwelingen KG, Van Uffelen R, Van Vliet ACM (1999) The sleep apnoea syndromes. Eur Heart J 20:858–866CrossRef
39.
Zurück zum Zitat Vazquez JC, Tsai WH, Flemons WW et al (2000) Automated analysis of digital oximetry in the diagnosis of obstructive sleep apnoea. Thorax 55:302–307CrossRef Vazquez JC, Tsai WH, Flemons WW et al (2000) Automated analysis of digital oximetry in the diagnosis of obstructive sleep apnoea. Thorax 55:302–307CrossRef
40.
Zurück zum Zitat Young T, Peppard PE, Gottlieb DJ (2002) Epidemiology of obstructive sleep apnea: a population health perspective. Am J Respir Crit Care Med 165:1217–1239CrossRef Young T, Peppard PE, Gottlieb DJ (2002) Epidemiology of obstructive sleep apnea: a population health perspective. Am J Respir Crit Care Med 165:1217–1239CrossRef
41.
Zurück zum Zitat Zhang GP (2000) Neural networks for classification: a survey. IEEE Trans Syst Man Cybern Part C Appl Rev 30:451–462CrossRef Zhang GP (2000) Neural networks for classification: a survey. IEEE Trans Syst Man Cybern Part C Appl Rev 30:451–462CrossRef
Metadaten
Titel
Radial basis function classifiers to help in the diagnosis of the obstructive sleep apnoea syndrome from nocturnal oximetry
verfasst von
J. Víctor Marcos
Roberto Hornero
Daniel Álvarez
Félix del Campo
Miguel López
Carlos Zamarrón
Publikationsdatum
01.04.2008
Verlag
Springer-Verlag
Erschienen in
Medical & Biological Engineering & Computing / Ausgabe 4/2008
Print ISSN: 0140-0118
Elektronische ISSN: 1741-0444
DOI
https://doi.org/10.1007/s11517-007-0280-0

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