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Erschienen in:
2016 | OriginalPaper | Buchkapitel
Recent Advances in Regenerative Approaches to Intervertebral Disc Degeneration
verfasst von : Gilson Khang, Jeong Eun Song, Nirmalya Tripathy, Eun Young Kim, Dongwon Lee
Erschienen in: Biomedical Engineering: Frontier Research and Converging Technologies
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Intervertebral disc (IVD) degeneration is one of the major neurodegenerative diseases throughout the world. Development of new and advanced treatment methods are highly warranted due to the limitations of conventional protocols. Very recently, regenerative medicine techniques based on biomaterials, stem cell and bioactive molecules have been demonstrated as the most powerful concept to regenerate IVD. In this chapter, we will review the recent progress in (1) biomaterial scaffolds for annulus fibrosus (AF), nucleus pulposus (NP) and cartilaginous end plates (CEP), (2) stem cells as cell sources, and finally introduce (3) our recent research studies focusing on the fabrication of natural/synthetic hybrid scaffolds for various purposes during the last 5 years.