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01.01.2014 | Research Paper

Single-walled carbon nanohorns decorated with semiconductor quantum dots to evaluate intracellular transport

verfasst von: Kristen A. Zimmermann, David L. Inglefield Jr., Jianfei Zhang, Harry C. Dorn, Timothy E. Long, Christopher G. Rylander, M. Nichole Rylander

Erschienen in: Journal of Nanoparticle Research | Ausgabe 1/2014

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Abstract

Single-walled carbon nanohorns (SWNHs) have great potential to enhance thermal and chemotherapeutic drug efficiencies for cancer therapies. Despite their diverse capabilities, minimal research has been conducted so far to study nanoparticle intracellular transport, which is an important step in designing efficient therapies. SWNHs, like many other carbon nanomaterials, do not have inherent fluorescence properties making intracellular transport information difficult to obtain. The goals of this project were to (1) develop a simple reaction scheme to decorate the exohedral surface of SWNHs with fluorescent quantum dots (QDs) and improve conjugate stability, and (2) evaluate SWNH–QD conjugate cellular uptake kinetics and localization in various cancer cell lines of differing origins and morphologies. In this study, SWNHs were conjugated to CdSe/ZnS core/shell QDs using a unique approach to carbodiimide chemistry. Transmission electron microscopy and electron dispersive spectroscopy verified the conjugation of SWNHs and QDs. Cellular uptake kinetics and efficiency were characterized in three malignant cell lines: U-87 MG (glioblastoma), MDA-MB-231 (breast cancer), and AY-27 (bladder transitional cell carcinoma) using flow cytometry. Cellular distribution was verified by confocal microscopy, and cytotoxicity was also evaluated using an alamarBlue assay. Results indicate that cellular uptake kinetics and efficiency are highly dependent on cell type, highlighting the significance of studying nanoparticle transport at the cellular level. Nanoparticle intracellular transport investigations may provide information to optimize treatment parameters (e.g., SWNH concentration, treatment time, etc.) depending on tumor etiology.

Vorheriger Artikel A settling tube to determine the terminal velocity and size distribution of fluidized nanoparticle agglomerates

Nächster Artikel Effects of the physicochemical properties of titanium dioxide nanoparticles, commonly used as sun protection agents, on microvascular endothelial cells

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Titel: Single-walled carbon nanohorns decorated with semiconductor quantum dots to evaluate intracellular transport
verfasst von: Kristen A. Zimmermann
David L. Inglefield Jr.
Jianfei Zhang
Harry C. Dorn
Timothy E. Long
Christopher G. Rylander
M. Nichole Rylander
Publikationsdatum: 01.01.2014
Verlag: Springer Netherlands
Erschienen in: Journal of Nanoparticle Research / Ausgabe 1/2014
Print ISSN: 1388-0764
Elektronische ISSN: 1572-896X
DOI: https://doi.org/10.1007/s11051-013-2078-3

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