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2019 | OriginalPaper | Buchkapitel

Spiroketal Phthalane C-Glycosides: Synthesis of Papulacandins and SGLT2 Inhibitors

verfasst von : Yoshihiko Yamamoto

Erschienen in: Carbohydrate-spiro-heterocycles

Verlag: Springer International Publishing

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Abstract

Spiroketals are important structural motifs found in diverse natural products, many of which display unique biological activity. Among them, spiroketal phthalane C-glycosides, in which a phthalane ring and sugar unit form a spiroketal framework, have garnered enormous attention from wide research areas because such a fascinating spirocycle motif is found in antibiotic natural products, i.e., papulacandins and their relatives. Moreover, recent reports from pharmaceutical researchers have revealed that spiroketal phthalane C-glycosides are potent drug candidates for type 2 diabetes. Accordingly, the efficient and selective construction of the spiroketal phthalane C-glycoside motif is an important research objective in synthetic organic chemistry. In this chapter, recent advances in the synthesis of spiroketal phthalane C-glycosides will be discussed.

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Vorheriges Kapitel Recent Advances in the Chemistry and Biology of Spirocyclic Nucleosides

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Titel: Spiroketal Phthalane C-Glycosides: Synthesis of Papulacandins and SGLT2 Inhibitors
verfasst von: Yoshihiko Yamamoto
Verlag: Springer International Publishing
Buch: Carbohydrate-spiro-heterocycles
Print ISBN: 978-3-030-31941-0

Electronic ISBN: 978-3-030-31942-7

Copyright-Jahr: 2019
DOI: https://doi.org/10.1007/7081_2018_27