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2012 | OriginalPaper | Buchkapitel

Stem Cell Differentiation Depending on Different Surfaces

verfasst von : Sonja Kress, Anne Neumann, Birgit Weyand, Cornelia Kasper

Erschienen in: Tissue Engineering III: Cell - Surface Interactions for Tissue Culture

Verlag: Springer Berlin Heidelberg

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Abstract

Mesenchymal stem cells and 3D biomaterials are a potent assembly in tissue engineering. Today, a sizable number of biomaterials has been characterized for special tissue engineering applications. However, diverse material properties, such as soft or hard biomaterials, have a specific influence on cell behavior. Not only the cell attachment and proliferation, but also differentiation is controlled by the microenvironment. Material characteristics such as pore size, stiffness, roughness, and geometry affect not only the cell attachment and proliferation, but also the differentiation behavior of mesenchymal stem cells. Optimization of these features might enable direct differentiation without adjustment of the culture medium by applying expensive growth or differentiation factors. Future aspects include the design of multilayered biomaterials, where each zone fulfills a distinct function. Moreover, the embedding of growth and differentiation factors into the matrix with a controlled release rate might be advantageous to direct differentiation.

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Vorheriges Kapitel Microenvironment Design for Stem Cell Fate Determination

Nächstes Kapitel Designing the Biocompatibility of Biohybrids

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Titel: Stem Cell Differentiation Depending on Different Surfaces
verfasst von: Sonja Kress
Anne Neumann
Birgit Weyand
Cornelia Kasper
Verlag: Springer Berlin Heidelberg
Buch: Tissue Engineering III: Cell - Surface Interactions for Tissue Culture
Print ISBN: 978-3-642-28281-2

Electronic ISBN: 978-3-642-28282-9

Copyright-Jahr: 2012
DOI: https://doi.org/10.1007/10_2011_108

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