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Erschienen in: Journal of Nanoparticle Research 4/2013

01.04.2013 | Research Paper

Streptavidin-conjugated CdSe/ZnS quantum dots impaired synaptic plasticity and spatial memory process

verfasst von: Xiaoyan Gao, Mingliang Tang, Zhifeng Li, Yingying Zha, Guosheng Cheng, Shuting Yin, Jutao Chen, Di-yun Ruan, Lin Chen, Ming Wang

Erschienen in: Journal of Nanoparticle Research | Ausgabe 4/2013

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Abstract

Studies reported that quantum dots (QDs), as a novel probe, demonstrated a promising future for in vivo imaging, but also showed potential toxicity. This study is mainly to investigate in vivo response in the central nervous system (CNS) after exposure to QDs in a rat model of synaptic plasticity and spatial memory. Adult rats were exposed to streptavidin-conjugated CdSe/ZnS QDs (Qdots 525, purchased from Molecular Probes Inc.) by intraperitoneal injection for 7 days, followed by behavioral, electrophysiological, and biochemical examinations. The electrophysiological results show that input/output (I/O) functions were increased, while the peak of paired-pulse reaction and long-term potentiation were decreased after QDs insult, indicating synaptic transmission was enhanced and synaptic plasticity in the hippocampus was impaired. Meanwhile, behavioral experiments provide the evidence that QDs could impair rats’ spatial memory process. All the results present evidences of interference of synaptic transmission and plasticity in rat hippocampal dentate gyrus area by QDs insult and suggest potential adverse issues which should be considered in QDs applications.

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Metadaten
Titel
Streptavidin-conjugated CdSe/ZnS quantum dots impaired synaptic plasticity and spatial memory process
verfasst von
Xiaoyan Gao
Mingliang Tang
Zhifeng Li
Yingying Zha
Guosheng Cheng
Shuting Yin
Jutao Chen
Di-yun Ruan
Lin Chen
Ming Wang
Publikationsdatum
01.04.2013
Verlag
Springer Netherlands
Erschienen in
Journal of Nanoparticle Research / Ausgabe 4/2013
Print ISSN: 1388-0764
Elektronische ISSN: 1572-896X
DOI
https://doi.org/10.1007/s11051-013-1575-8

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