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01.07.2014 | Research Paper

Synthesis and characterization of covalent diphenylalanine nanotube-folic acid conjugates

verfasst von: John J. Castillo, Tomas Rindzevicius, Kaiyu Wu, Michael S. Schmidt, Katarzyna A. Janik, Anja Boisen, Winnie Svendsen, Noemi Rozlosnik, Jaime Castillo-León

Erschienen in: Journal of Nanoparticle Research | Ausgabe 7/2014

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Abstract

Herein, we describe the synthesis and characterization of a covalent nanoscale assembly formed between diphenylalanine micro/nanotubes (PNT) and folic acid (FA). The conjugate was obtained via chemical functionalization through coupling of amine groups of PNTs and carboxylic groups of FA. The surface analysis of PNT-FA indicated the presence of FA aggregates on the surface of PNTs. The covalent interaction between FA and self-assembled PNTs was further investigated using fluorescence microscopy, Raman and surface-enhanced Raman scattering (SERS) spectroscopies. The SERS experiments were performed on a large area silver-capped (diameter of 62 nm) silicon nanopillars with an approximate height of 400 nm and a width of 200 nm. The results showed that the PNT-FA synthesis procedure preserves the molecular structure of FA. The PNT-FA conjugate presented in this study is a promising candidate for applications in the detection and diagnosis of cancer or tropical diseases such as leishmaniasis and as a carrier nanosystem delivering drugs to malignant tumors that overexpress folate receptors.

Vorheriger Artikel Detailed kinetic analysis of the impact of nucleation behavior and particle size distribution on the configurations of carbon black

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Titel: Synthesis and characterization of covalent diphenylalanine nanotube-folic acid conjugates
verfasst von: John J. Castillo
Tomas Rindzevicius
Kaiyu Wu
Michael S. Schmidt
Katarzyna A. Janik
Anja Boisen
Winnie Svendsen
Noemi Rozlosnik
Jaime Castillo-León
Publikationsdatum: 01.07.2014
Verlag: Springer Netherlands
Erschienen in: Journal of Nanoparticle Research / Ausgabe 7/2014
Print ISSN: 1388-0764
Elektronische ISSN: 1572-896X
DOI: https://doi.org/10.1007/s11051-014-2525-9

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