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01.06.2014 | Original Paper

Synthesis and characterization of thermosensitive, star-shaped poly(ε-caprolactone)-block-Poly(N-isopropylacrylamide) with porphyrin-core for photodynamic therapy

verfasst von: Xiao-Hui Dai, Hua Jin, Si-Song Yuan, Jian-Ming Pan, Xiao-Hong Wang, Yong-Sheng Yan, Dong-Ming Liu, Lin Sun

Erschienen in: Journal of Polymer Research | Ausgabe 6/2014

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Abstract

Thermosensitive, amphiphilic, star-shaped poly (ε-caprolactone)-block-poly (N-isopropylacrylamide) with prophyrin-core (SPPCL-b-PNIPAAm) was synthesized by ring-opening polymerization (ROP) and reversible addition-fragmentation chain transfer polymerization (RAFT) and characterized by NMR, IR, GPC in this study. The optical transmittance results showed that the lower critical solution temperatures (LCST) of the copolymer solutions were attractively close to normal physiologic temperature at around 37 °C. Due to its amphiphilic property, the obtained SPPCL-b-PNIPAAm had a low critical micelle concentration (CMC) in an aqueous solution and self-assembled into micelles in water. Transmission electron microscopy (TEM) and dynamic light scattering (DLS) analysis of micelle morphology revealed a well-defined spherical shape with a diameter of around 100 nm. Moreover, SPPCL-b-PNIPAAm micelles obtained high singlet oxygen quantum yields and indicated a sensitivity to temperature, suggesting that the SPPCL-b-PNIPAAm was a stimulus-responsive photosensitizer which had a potential application in targeted photodynamic therapy.

Vorheriger Artikel Fabrication of ordered honeycomb structures and microspheres using polystyrene-block-poly(tert-butyl acrylate) star polymers

Nächster Artikel A novolac epoxy resin modified polyurethane acylates polymer grafted network with enhanced thermal and mechanical properties

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Titel: Synthesis and characterization of thermosensitive, star-shaped poly(ε-caprolactone)-block-Poly(N-isopropylacrylamide) with porphyrin-core for photodynamic therapy
verfasst von: Xiao-Hui Dai
Hua Jin
Si-Song Yuan
Jian-Ming Pan
Xiao-Hong Wang
Yong-Sheng Yan
Dong-Ming Liu
Lin Sun
Publikationsdatum: 01.06.2014
Verlag: Springer Netherlands
Erschienen in: Journal of Polymer Research / Ausgabe 6/2014
Print ISSN: 1022-9760
Elektronische ISSN: 1572-8935
DOI: https://doi.org/10.1007/s10965-014-0412-9

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