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Arabian Journal for Science and Engineering
Erschienen in: Arabian Journal for Science and Engineering 7/2019

30.05.2019 | Research Article-Chemistry

Synthesis, Characterization and Hydrolytic Degradation of p-Cresol-Substituted Polyphosphazenes

verfasst von: Tanzeela Gulab Shahzady, Shazia Khurshid, Amin Abid, Zulfiqar Ali, Shumaila Razzaque, Hajira Rehman, Asmat Zahra, Shabbir Hussain, Muhammad Waqas

Erschienen in: Arabian Journal for Science and Engineering | Ausgabe 7/2019

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Abstract

Two polymers poly[bis(p-Cresol)phosphazenes] (PBPP) and poly[bis(p-cresoldiethyl amino)phosphazenes] (PBPDEAP) were synthesized, characterized and subjected to hydrolytic degradation and investigated in vitro degradation for drug delivery. The syntheses were carried out by thermal ring-opening polymerization followed by chlorine replacement via macromolecular substitution reaction. The polymeric products were characterized by FTIR, 1H NMR, thermal analysis (DSC), elemental analysis and gel permeation chromatography (GPC) analysis. Hydrolytic degradation was observed by percentage weight loss in buffer solutions of a broad pH range (4.5–10) in deionized water at body temperature (37 °C). It was found that PBPDEAP degraded more rapidly than PBPP, and hydrolytic degradation mechanism was proposed. It was found that PBPP and PBPDEAP are biodegradable, biocompatible and non-toxic and can be tailored for in vitro and later in vivo studies.
Vorheriger Artikel Synthesis of Eco-friendly Cobalt Nanoparticles Using Celosia argentea Plant Extract and Their Efficacy Studies as Antioxidant, Antibacterial, Hemolytic and Catalytical Agent
Nächster Artikel Comparative Study between Indigenous Natural Coagulants and Alum for Microalgae Harvesting

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Metadaten
Titel
Synthesis, Characterization and Hydrolytic Degradation of p-Cresol-Substituted Polyphosphazenes
verfasst von
Tanzeela Gulab Shahzady
Shazia Khurshid
Amin Abid
Zulfiqar Ali
Shumaila Razzaque
Hajira Rehman
Asmat Zahra
Shabbir Hussain
Muhammad Waqas
Publikationsdatum
30.05.2019
Verlag
Springer Berlin Heidelberg
Erschienen in
Arabian Journal for Science and Engineering / Ausgabe 7/2019
Print ISSN: 2193-567X
Elektronische ISSN: 2191-4281
DOI
https://doi.org/10.1007/s13369-019-03952-1

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