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Polymer Bulletin
Erschienen in: Polymer Bulletin 11/2017

09.03.2017 | Original Paper

Synthesis of amphiphilic fluorescent copolymers with smart pH sensitivity via RAFT polymerization and their application in cell imaging

verfasst von: Zengfang Huang, Xiqi Zhang, Xiaoyong Zhang, Shiqi Wang, Bin Yang, Ke Wang, Jinying Yuan, Lei Tao, Yen Wei

Erschienen in: Polymer Bulletin | Ausgabe 11/2017

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Abstract

In this paper, a fluorescein methacryloyl monomer (named Flu-MA) was firstly fabricated by the esterification reaction of fluorescein and methacryloyl chloride; subsequently, a novel amphiphilic fluorescent copolymer (Flu-PEG) with smart pH sensitivity was successfully prepared by RAFT copolymerizing of Flu-MA and poly(ethylene glycol) monomethacrylate (PEGMA). The result of 1H NMR and FTIR implied that both Flu-MA and PEGMA monomers were successfully incorporated into Flu-PEG copolymers, the molecular weight (M n) of which was about 39,800 with polydispersity index (PDI) as about 1.30. In aqueous solution, Flu-PEG copolymers could self-assemble into fluorescent organic nanoparticles (FONs) with about 200 nm diameters due to high water dispersibility and good fluorescence, respectively, endowed by PEGMA and Flu-MA, the fluorescence intensity of which was high sensitive to pH value of solution. More importantly, due to their high water dispersibility, excellent biocompatibility and good fluorescence, the as-prepared Flu-PEG FONs were high attractive for the application in cell imaging.

Graphical abstract

A novel amphiphilic fluorescent copolymer (Flu-PEG) with smart pH-sensitivity was successfully fabricated by RAFT copolymerizing of Flu-MA and PEGMA, which showed high water dispersibility, uniform size and excellent biocompatibility, making them be highly potential for bioimaging application.
Vorheriger Artikel Effects of high-boiling-point additive 2-Bromonaphthalene on polymer solar cells fabricated in ambient air
Nächster Artikel Wear resistance and friction coefficient of nano-SiO2 and ash-filled HDPE/lignocellulosic fiber composites

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Metadaten
Titel
Synthesis of amphiphilic fluorescent copolymers with smart pH sensitivity via RAFT polymerization and their application in cell imaging
verfasst von
Zengfang Huang
Xiqi Zhang
Xiaoyong Zhang
Shiqi Wang
Bin Yang
Ke Wang
Jinying Yuan
Lei Tao
Yen Wei
Publikationsdatum
09.03.2017
Verlag
Springer Berlin Heidelberg
Erschienen in
Polymer Bulletin / Ausgabe 11/2017
Print ISSN: 0170-0839
Elektronische ISSN: 1436-2449
DOI
https://doi.org/10.1007/s00289-017-1969-3

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