In recent years. substance P and related tachykinins have been shown to stimulate inositol phospholipid hydrolysis in a variety of tissues, including rat salivary gland , guinea pig ileum longitudinal muscle and rat hypothalamus . In these tissues substance P, eledoisin and substance P methyl ester possess similar nanomolar potencies at inducing this response suggesting that inositol phospholipid breakdown is associated with SP-P receptor activation . However. in slices of rat ileum longitudinal muscle. eledoisin is considerably more potent than substance P at stimulating inositol phospholipid hydrolysis suggesting that in some tissues this response may be mediated by a SP-E receptor . In order to investigate further the association of SP-E receptors with inositol phospholipid breakdown, we examined tachykinin-induced inositol-l-phosphate production in slices of hamster urinary bladder, a tissue whose contractile response exhibits a typical SP-E receptor profile .
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- Tachykinin-Induced Phosphatidylinositol Turnover in Hamster Urinary Bladder
K. J. Watling
D. R. Bristow
- Springer New York
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