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2020 | OriginalPaper | Buchkapitel

TBAF Fluorination for Preparing Alkyl Fluorides

verfasst von : Haoran Sun, Stephen G. DiMagno

Erschienen in: Fluorination

Verlag: Springer Singapore

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Fluorinated alkyl substituents appear widely in medicinal and pharmaceutical chemistry [1‐7], and [¹⁸F]-fluorinated ethyl or propyl tags are increasingly common tools radiochemists use to prepare [¹⁸F]-labeled radiopharmaceuticals for positron emission tomography (PET) [8‐11]. Numerous fluorinating reagents that are available to prepare alkyl fluorides through nucleophilic, electrophilic, and radical approaches are covered elsewhere in this volume. Here we will review fluorinations with the readily available and prototypical nucleophilic fluorinating reagent tetrabutylammonium fluoride (TBAF) and its derivatives. …

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Vorheriges Kapitel TASF Fluorination for Preparing Alkyl Fluorides

Nächstes Kapitel Tetrafluoroborate Salt Fluorination for Preparing Alkyl Fluorides

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Titel: TBAF Fluorination for Preparing Alkyl Fluorides
verfasst von: Haoran Sun
Stephen G. DiMagno
Verlag: Springer Singapore
Buch: Fluorination
Print ISBN: 978-981-10-3895-2

Electronic ISBN: 978-981-10-3896-9

Copyright-Jahr: 2020
DOI: https://doi.org/10.1007/978-981-10-3896-9_14

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