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Journal of Polymer Research
Erschienen in: Journal of Polymer Research 4/2016

01.04.2016

Temperature/pH dual responsive OPGMA based copolymeric hydrogels prepared by gamma radiation: an optimisation study

verfasst von: Z. Rogic Miladinovic, M. Micic, E. Suljovrujic

Erschienen in: Journal of Polymer Research | Ausgabe 4/2016

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Abstract

The purpose of this study was to attain oligo(propylene glycol) methacrylate (OPGMA) based hydrogels for different biomedical applications. Since the volume phase transition temperature (VPTT) of poly(oligo(propylene glycol) methacrylate) (POPGMA) homopolymer was below room temperature, it was necessary to tune the thermoresponsiveness and the VPTT to higher temperatures; radical copolymerisation of OPGMA with more hydrophilic and/or pH responsive monomers was used to adjust these values. A series of copolymeric hydrogels with different ratios of OPGMA, 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) was synthesised by gamma radiation. The swelling properties were preliminarily investigated over a wide pH (2.2–9.0) and temperature (4–80 °C) ranges. Additional characterization of their structure and properties was conducted by Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM) and differential scanning calorimetry (DSC). The presented results revealed temperature/pH dual responsive P(OPGMA/IA) and P(OPGMA/HEMA/IA) copolymers with large diversity in swelling properties, as a result of the addition of OPGMA thermoresponsive units with a lower critical solution temperature (LCST) and IA pH responsive units. It was demonstrated that VPTT can be significantly shifted to higher (e.g. body) temperatures at higher pH values (pH ≥ 4) by increasing the IA content in the hydrogel composition. Due to the possibility of making dual responsive copolymers in the manner explained in this paper, OPGMA based hydrogels show potential for different biomedical applications.
Vorheriger Artikel Fabrication of thermo-sensitive optical switches based on lanthanide-polyoxometalates and their “on-off” luminescence controlled by temperature
Nächster Artikel Structural and rheological properties of kappa (κ)-carrageenans covalently modified with cationic moieties

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Metadaten
Titel
Temperature/pH dual responsive OPGMA based copolymeric hydrogels prepared by gamma radiation: an optimisation study
verfasst von
Z. Rogic Miladinovic
M. Micic
E. Suljovrujic
Publikationsdatum
01.04.2016
Verlag
Springer Netherlands
Erschienen in
Journal of Polymer Research / Ausgabe 4/2016
Print ISSN: 1022-9760
Elektronische ISSN: 1572-8935
DOI
https://doi.org/10.1007/s10965-016-0975-8

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