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2019 | OriginalPaper | Buchkapitel

The Probablistic Random Forest Clinico-Statistical Regression Analysis of MER Signals with STN-DBS and Enhancement of UPDRS

verfasst von : Venkateshwarla Rama Raju

Erschienen in: World Congress on Medical Physics and Biomedical Engineering 2018

Verlag: Springer Singapore

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Abstract

In this study, we present classification and regression analysis to predict the UPDRS score and its enhancement after the microelectrode STN signal recording (MER) with DBS surgery (implantation of the microelectrode). We hypothesized that a data informed grouping of features extrapolated from MER signals of STN can envisage restore (by decreasing the tremor) and functioning the motor improvement in Parkinson’s disease (PD) patients. A random—forest is used to account for unbalanced datasets and multiple observations per PD subject, and showed that only five features of STN-MER signals are sufficient and account for prognosting UPDRS advancement. This finding suggests that STN signal characteristics are maximum correlated to the extent of improvement motor restoration and motor behavior observed in STN DBS.

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Literatur
1.
Zurück zum Zitat Juliann, Schaeffer., New Hope in Neuroprotection? A Parkinson’s disease Update. Neuroprotection has become the focus of efforts aimed at slowing the progression of Parkinson`s disease, Nature.com 1–4 (2017). Juliann, Schaeffer., New Hope in Neuroprotection? A Parkinson’s disease Update. Neuroprotection has become the focus of efforts aimed at slowing the progression of Parkinson`s disease, Nature.com 1–4 (2017).
2.
Zurück zum Zitat Benabid, AL., Koudsie, A., Benazzouz, A., Vercueil, L., Fraix V., Chabardes, S., LeBas, JF., Pollak, P.: Deep brain stimulation of the corpus luysi (subthalamic nucleus) and other targets in Parkinson’s disease. Extension to new indications such as dystonia and epilepsy. J Neurol 248(3), III37–III47 (2001). Benabid, AL., Koudsie, A., Benazzouz, A., Vercueil, L., Fraix V., Chabardes, S., LeBas, JF., Pollak, P.: Deep brain stimulation of the corpus luysi (subthalamic nucleus) and other targets in Parkinson’s disease. Extension to new indications such as dystonia and epilepsy. J Neurol 248(3), III37–III47 (2001).
3.
Zurück zum Zitat Benabid, AL., Krack, PP., Benazzouz, A., Limousin, P., Koudsie, A., Pollak, P.: Deep brain stimulation of the subthalamic nucleus for Parkinson’s disease: methodologic aspects and clinical criteria. Neurology 55:S40–S44 (2000). Benabid, AL., Krack, PP., Benazzouz, A., Limousin, P., Koudsie, A., Pollak, P.: Deep brain stimulation of the subthalamic nucleus for Parkinson’s disease: methodologic aspects and clinical criteria. Neurology 55:S40–S44 (2000).
4.
Zurück zum Zitat J, Jankovic.: Parkinson’s disease: Clinical features and diagnosis. J. Neu-rol. Neurosurg. Psychiatry 79(4), 368–376 (2008). J, Jankovic.: Parkinson’s disease: Clinical features and diagnosis. J. Neu-rol. Neurosurg. Psychiatry 79(4), 368–376 (2008).
5.
Zurück zum Zitat Tugwell, C.: Parkinson’s disease in focus. Pharmaceutical Press, London (2008). Tugwell, C.: Parkinson’s disease in focus. Pharmaceutical Press, London (2008).
6.
Zurück zum Zitat Yashar, Sarbaz., Hakimeh, Pourakbari.: A review of presented mathematical models in Parkinson’s disease: black and gray box models. Med Biol Eng Comput 54, 855–868 (2016). Yashar, Sarbaz., Hakimeh, Pourakbari.: A review of presented mathematical models in Parkinson’s disease: black and gray box models. Med Biol Eng Comput 54, 855–868 (2016).
7.
Zurück zum Zitat Parkinson, J.: An Essay on Shaking Palsy, Sherwood, Neely and Jones: London (1817). Parkinson, J.: An Essay on Shaking Palsy, Sherwood, Neely and Jones: London (1817).
8.
Zurück zum Zitat K, Ray Chaudhuri., Victor, SC Fung., Fast Facts: Parkinson`s Disease. Fourth Edition, Health Press Ltd. London (2016). K, Ray Chaudhuri., Victor, SC Fung., Fast Facts: Parkinson`s Disease. Fourth Edition, Health Press Ltd. London (2016).
9.
Zurück zum Zitat Ronald, F. Pfeiffer., Zbgkiew, K. Wazolek., Manuchair, Ebadi.: Parkinson`s Disease, CRC Press, Taylor & Francis Group (2013). Ronald, F. Pfeiffer., Zbgkiew, K. Wazolek., Manuchair, Ebadi.: Parkinson`s Disease, CRC Press, Taylor & Francis Group (2013).
10.
Zurück zum Zitat Alim, Luis Benabid.: Laskar Award Winner, Nature Medicine. 10 (20), 1–3 (2014). Alim, Luis Benabid.: Laskar Award Winner, Nature Medicine. 10 (20), 1–3 (2014).
11.
Zurück zum Zitat Mahlon, DeLong.: Laskar Award Winner, Nature Medicine. 10 (20), 4–6 (2014). Mahlon, DeLong.: Laskar Award Winner, Nature Medicine. 10 (20), 4–6 (2014).
12.
Zurück zum Zitat Larry, Squire., Darwin, Berg., Floyd, E. Bloom., Sascha, du. Lac., Anirvan, Ghosh., Nicholas C. Spitzer.: Fundamental Neuroscience, 4th Edition. AP Academic Press (2012). Larry, Squire., Darwin, Berg., Floyd, E. Bloom., Sascha, du. Lac., Anirvan, Ghosh., Nicholas C. Spitzer.: Fundamental Neuroscience, 4th Edition. AP Academic Press (2012).
13.
Zurück zum Zitat Duane E. Haines., Gregory A. Mihailoff.: Fundamental Neuroscience for Basic and Clinical Applications. E-Book 5th Edition. ELSEVIER (2018). Duane E. Haines., Gregory A. Mihailoff.: Fundamental Neuroscience for Basic and Clinical Applications. E-Book 5th Edition. ELSEVIER (2018).
14.
Zurück zum Zitat Ashkan, K., Blomstedt, P., Zrinzo, L., Tisch, S., Yousry, T., Limousin-Dowsey, P.: Variability of the subthalamic nucleus: the case for direct MRI guided targeting. Br J Neurosurg. 21 (2), 197–200 (2007). Ashkan, K., Blomstedt, P., Zrinzo, L., Tisch, S., Yousry, T., Limousin-Dowsey, P.: Variability of the subthalamic nucleus: the case for direct MRI guided targeting. Br J Neurosurg. 21 (2), 197–200 (2007).
15.
Zurück zum Zitat Patel, NK., Khan, S., Gill, SS.: Comparison of atlas- and magnetic-resonance-imaging-based stereotactic targeting of the subthalamic nucleus in the surgical treatment of Parkinson’s disease. Stereotact Funct Neurosurg. 86(3), 153–61 (2008). Patel, NK., Khan, S., Gill, SS.: Comparison of atlas- and magnetic-resonance-imaging-based stereotactic targeting of the subthalamic nucleus in the surgical treatment of Parkinson’s disease. Stereotact Funct Neurosurg. 86(3), 153–61 (2008).
16.
Zurück zum Zitat Andrade-Souza, YM., Schwalb, JM., Hamani, C., Eltahawy, H., Hoque, T., Saint-Cyr, J., Lozano, AM.: Comparison of three methods of targeting the subthalamic nucleus for chronic stimulation in Parkinson’s disease. Neurosurgery. 62 (2), 875–83 (2008). Andrade-Souza, YM., Schwalb, JM., Hamani, C., Eltahawy, H., Hoque, T., Saint-Cyr, J., Lozano, AM.: Comparison of three methods of targeting the subthalamic nucleus for chronic stimulation in Parkinson’s disease. Neurosurgery. 62 (2), 875–83 (2008).
17.
Zurück zum Zitat B. W. Mathews.: Comparison of the predicted and observed secondary structure of T4 phage lysozyme. Biochim. Biophys. Acta. Protein Struct. 405(2), 442–451 (1975). B. W. Mathews.: Comparison of the predicted and observed secondary structure of T4 phage lysozyme. Biochim. Biophys. Acta. Protein Struct. 405(2), 442–451 (1975).
18.
Zurück zum Zitat Parkinson J.: An Essay on Shaking Palsy, Sherwood, Neely and Jones: London (1817). Parkinson J.: An Essay on Shaking Palsy, Sherwood, Neely and Jones: London (1817).
Metadaten
Titel
The Probablistic Random Forest Clinico-Statistical Regression Analysis of MER Signals with STN-DBS and Enhancement of UPDRS
verfasst von
Venkateshwarla Rama Raju
Copyright-Jahr
2019
Verlag
Springer Singapore
DOI
https://doi.org/10.1007/978-981-10-9023-3_9

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