nach oben

Erschienen in:

2022 | OriginalPaper | Buchkapitel

3. Therapeutic Mechanisms of Gut Microbiota and Probiotics in the Management of Mental Disorders

verfasst von : Monu Yadav, Anil Kumar, Amarjeet Shandil

Erschienen in: Probiotic Research in Therapeutics

Verlag: Springer Nature Singapore

Einloggen

Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.

search-config

KI-gestützte Suche

Aus

Abstract

Probiotics are live microorganisms which work for the human benefit by improving their intestinal microbial balance. Originally they were used to enhance both animals and humans health by modulating intestinal microbiota. There is a biological connection between probiotics and brain as they can communicate via neurotransmitters system, anti-oxidative defence mechanism and neuroinflammatory pathways. Probiotic bacteria are also involved in the production of neuroactive molecules that act on the brain–gut axis. Probiotic treatments that help to improve mood, anxiety and strengthen memory using them in the form of food or supplements to alter the gut microbiota and treat psychiatric conditions are considered as psychobiotics. Dietary ingestion such as prebiotics, probiotics and polyphenol can influence gut microbiota composition. Dysbiosis of the gut microbiota is associated with brain dysfunctions. Regulation of microbiota by probiotics and prebiotics may help to restore gut equilibrium. The impact of nutrients on microbiota composition strengthens the reports that regulating a therapeutic microbiota is essential for a healthy brain. They could be useful as novel therapeutics to protect the brain from neurodegeneration. But research is still needed, mainly clinical and translational studies to determine pharmacokinetics and pharmacodynamics of probiotics.

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

über 102.000 Bücher
über 537 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Finance + Banking
Management + Führung
Marketing + Vertrieb
Maschinenbau + Werkstoffe
Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Jetzt informieren

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

über 67.000 Bücher
über 390 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Maschinenbau + Werkstoffe

Jetzt Wissensvorsprung sichern!

Jetzt informieren

Springer Professional "Wirtschaft"

Online-Abonnement

Mit Springer Professional "Wirtschaft" erhalten Sie Zugriff auf:

über 67.000 Bücher
über 340 Zeitschriften

aus folgenden Fachgebieten:

Bauwesen + Immobilien
Business IT + Informatik
Finance + Banking
Management + Führung
Marketing + Vertrieb
Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Jetzt informieren

Vorheriges Kapitel Critical Inspection of the Gut–Brain–Skin Triangle and Its Modulation Through Probiotics

Nächstes Kapitel Pathophysiological Role of Gut Microbiota Affecting Gut–Brain Axis and Intervention of Probiotics and Prebiotics in Autism Spectrum Disorder

Allen AP, Hutch W, Borre YE, Kennedy PJ, Temko A, Boylan G, Murphy E, Cryan JF, Dinan TG, Clarke G (2016) Bifidobacterium longum 1714 as a translational psychobiotic: modulation of stress, electrophysiology and neurocognition in healthy volunteers. Transl Psychiatry 6(11):1–7CrossRef

Alonso C, Vicario M, Santos J, Azpiroz F (2011) Stress, intestinal inflammation, and irritable bowel syndrome. Ann Gastroenterol Hepatol:1–10

Arborelius L, Owens MJ, Plotsky PM, Nemeroff CB (1999) The role of corticotropin-releasing factor in depression and anxiety disorders. J Endocrinol 160(1):1–2PubMedCrossRef

Barrett E, Ross RP, O’Toole PW, Fitzgerald GF, Stanton C (2012) Gamma-aminobutyric acid production by culturable bacteria from the human intestine. J Appl Microbiol 113(2):411–417PubMedCrossRef

Bermúdez-Humarán LG, Salinas E, Ortiz GG, Ramirez-Jirano LJ, Morales JA, Bitzer-Quintero OK (2019) From probiotics to psychobiotics: live beneficial bacteria which act on the brain-gut axis. Nutrients 11(4):890PubMedCentralCrossRef

Borre YE, O’Keeffe GW, Clarke G, Stanton C, Dinan TG, Cryan JF (2014) Microbiota and neurodevelopmental windows: implications for brain disorders. Trends Mol Med 20(9):509–518PubMedCrossRef

Bravo JA, Forsythe P, Chew MV, Escaravage E, Savignac HM, Dinan TG, Bienenstock J, Cryan JF (2011) Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proc Natl Acad Sci 108(38):16050–16055PubMedPubMedCentralCrossRef

Butts KA, Phillips AG (2013) Glucocorticoid receptors in the prefrontal cortex regulate dopamine efflux to stress via descending glutamatergic feedback to the ventral tegmental area. Int J Neuropsychopharmacol 16(8):1799–1807PubMedCrossRef

Chyun YS, Kream BE, Raisz LG (1984) Cortisol decreases bone formation by inhibiting periosteal cell proliferation. Endocrinology 114(2):477–480PubMedCrossRef

Codling C, O’Mahony L, Shanahan F, Quigley EM, Marchesi JR (2010) A molecular analysis of fecal and mucosal bacterial communities in irritable bowel syndrome. Dig Dis Sci 55(2):392–397PubMedCrossRef

Corpuz HM, Ichikawa S, Arimura M, Mihara T, Kumagai T, Mitani T, Nakamura S, Katayama S (2018) Long-term diet supplementation with Lactobacillus paracasei K71 prevents age-related cognitive decline in senescence-accelerated mouse prone 8. Nutrients 10(6):762PubMedCentralCrossRef

Desbonnet L, Garrett L, Clarke G, Kiely B, Cryan JF, Dinan TG (2010) Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression. Neuroscience 170(4):1179–1188PubMedCrossRef

Dinan TG, Stanton C, Cryan JF (2013) Psychobiotics: a novel class of psychotropic. Biol Psychiatry 74:720–726PubMedCrossRef

Dowlati Y, Herrmann N, Swardfager W, Liu H, Sham L, Reim EK, Lanctot KL (2010) A meta-analysis of cytokines in major depression. Biol Psychiatry 67:446–457PubMedCrossRef

El-Ansary A, Al-Ayadhi L (2014) Relative abundance of short chain and polyunsaturated fatty acids in propionic acid-induced autistic features in rat pups as potential markers in autism. Lipids Health Dis 13(1):140PubMedPubMedCentralCrossRef

Elsenbruch S, Rosenberger C, Enck P, Forsting M, Schedlowski M, Gizewski ER (2010) Affective disturbances modulate the neural processing of visceral pain stimuli in irritable bowel syndrome: an fMRI study. Gut 59(4):489–495PubMedCrossRef

Feenstra MG, Kalsbeek A, Van Galen H (1992) Neonatal lesions of the ventral tegmental area affect monoaminergic responses to stress in the medial prefrontal cortex and other dopamine projection areas in adulthood. Brain Res 596(1–2):169–182PubMedCrossRef

Floyd RA (1999) Antioxidants, oxidative stress, and degenerative neurological disorders. Proc Soc Exp Biol Med 222(3):236–245PubMedCrossRef

Ganesh BP, Hall A, Ayyaswamy S, Nelson JW, Fultz R, Major A, Haag A, Esparza M, Lugo M, Venable S, Whary M (2018) Diacylglycerol kinase synthesized by commensal Lactobacillus reuteri diminishes protein-kinase C phosphorylation and histamine-mediated signaling in the mammalian intestinal epithelium. Mucosal Immunol 11(2):380–393PubMedCrossRef

Gao C, Major A, Rendon D, Lugo M, Jackson V, Shi Z, Mori-Akiyama Y, Versalovic J (2015) Histamine H2 receptor-mediated suppression of intestinal inflammation by probiotic Lactobacillus reuteri. Microbiology 6(6):e01358–e01315

Gautam M, Agrawal M, Gautam M, Sharma P, Gautam AS, Gautam S (2012) Role of antioxidants in generalised anxiety disorder and depression. Indian J Psychiatry 54(3):244PubMedPubMedCentralCrossRef

Gayathri D, Rashmi BS (2017) Mechanism of development of depression and probiotics as adjuvant therapy for its prevention and management. Mental Health Prevent 5:40–51CrossRef

Gill SR, Pop M, Deboy RT, Eckburg PB, Turnbaugh PJ, Samuel BS, Jeffrey IG, David AR, Claire MF, Karen EN (2006) Metagenomic analysis of the human distal gut microbiome. Science 312:1355–1359PubMedPubMedCentralCrossRef

Grunewald M, Johnson S, Lu D, Wang Z, Lomberk G, Albert PR, Stockmeier CA, Meyer JH, Urrutia R, Miczek KA, Austin MC (2012) Mechanistic role for a novel glucocorticoid-KLF11 (TIEG2) protein pathway in stress-induced monoamine oxidase A expression. J Biol Chem 287(29):24195–24206PubMedPubMedCentralCrossRef

Hansen MB (2003) Neurohumoral control of gastrointestinal motility. Physiol Res 52(1):1–30PubMed

Hauger RL, Risbrough V, Brauns O, Dautzenberg FM (2006) Corticotropin releasing factor (CRF) receptor signaling in the central nervous system: new molecular targets. CNS Neurologic Disord Drug Targets 5(4):453–479CrossRef

Hellström PM (1987) Mechanisms involved in colonic vasoconstriction and inhibition of motility induced by neuropeptide Y. Acta Physiol Scand 129(4):549–556PubMedCrossRef

Hooper LV, Littman DR, Macpherson AJ (2012) Interactions between the microbiota and the immune system. Science 336:1268–1273PubMedPubMedCentralCrossRef

Jang HM, Lee KE, Kim DH (2019) The preventive and curative effects of Lactobacillus reuteri NK33 and Bifidobacterium adolescentis NK98 on immobilization stress-induced anxiety/depression and colitis in mice. Nutrients 11(4):819PubMedCentralCrossRef

Janik R, Thomason LA, Stanisz AM, Forsythe P, Bienenstock J, Stanisz GJ (2016) Magnetic resonance spectroscopy reveals oral Lactobacillus promotion of increases in brain GABA, N-acetyl aspartate and glutamate. NeuroImage 125:988–995PubMedCrossRef

Kim GY, Lim JS, Lee SP (2018) Fortification of γ-aminobutyric acid and bioactive compounds in whey by co-fermentation using Bacillus subtilis and Lactobacillus plantarum. Kr J Food Sci Technol 50(6):572–580

Ko CY, Lin HT, Tsai GJ (2013) Gamma-aminobutyric acid production in black soybean milk by Lactobacillus brevis FPA 3709 and the antidepressant effect of the fermented product on a forced swimming rat model. Process Biochem 48(4):559–568CrossRef

de LeBlanc AM, Del Carmen S, Zurita-Turk M, Santos Rocha C, Van de Guchte M, Azevedo V, Miyoshi A, LeBlanc JG (2011) Importance of IL-10 modulation by probiotic microorganisms in gastrointestinal inflammatory diseases. ISRN Gastroenterol 2011:892971PubMedPubMedCentral

Liang S, Wang T, Hu X, Luo J, Li W, Wu X, Duan Y, Jin F (2015) Administration of Lactobacillus helveticus NS8 improves behavioral, cognitive, and biochemical aberrations caused by chronic restraint stress. Neuroscience 310:561–577PubMedCrossRef

Liu J, Sun J, Wang F, Yu X, Ling Z, Li H, Zhang H, Jin J, Chen W, Pang M, Yu J (2015) Neuroprotective effects of Clostridium butyricum against vascular dementia in mice via metabolic butyrate. Biomed Res Int 2015:1–12

Logan AC, Katzman M (2005) Major depressive disorder: probiotics may be an adjuvant therapy. Med Hypotheses 64(3):533–538PubMedCrossRef

Logan AC, Rao AV, Irani D (2003) Chronic fatigue syndrome: lactic acid bacteria may be of therapeutic value. Med Hypotheses 60(6):915–923PubMedCrossRef

Lu Y, Christian K, Lu B (2008) BDNF: a key regulator for protein synthesis-dependent LTP and long-term memory? Neurobiol Learn Mem 89:312–323PubMedCrossRef

Lutgendorff F, Akkermans L, Soderholm JD (2008) The role of microbiota and probiotics in stress-induced gastrointestinal damage. Curr Mol Med 8(4):282–298PubMedCrossRef

MacFabe DF (2012) Short-chain fatty acid fermentation products of the gut microbiome: implications in autism spectrum disorders. Microb Ecol Health Dis 23(1):19260

Maehata H, Kobayashi Y, Mitsuyama E, Kawase T, Kuhara T, Xiao JZ, Tsukahara T, Toyoda A (2019) Heat-killed Lactobacillus helveticus strain MCC1848 confers resilience to anxiety or depression-like symptoms caused by subchronic social defeat stress in mice. Biosci Biotechnol Biochem 83(7):1239–1247PubMedCrossRef

Maes M, Meltzer HY, Scharpè S, Bosmans E, Suy E, De Meester I, Calabrese J, Cosyns P (1993) Relationships between lower plasma L-tryptophan levels and immune-inflammatory variables in depression. Psychiatry Res 49(2):151–165PubMedCrossRef

Marin IA, Goertz JE, Ren T, Rich SS, Onengut-Gumuscu S, Farber E, Wu M, Overall CC, Kipnis J, Gaultier A (2017) Microbiota alteration is associated with the development of stress-induced despair behavior. Sci Rep 7:43859PubMedPubMedCentralCrossRef

Marrone MC, Coccurello R (2020) Dietary fatty acids and microbiota-brain communication in neuropsychiatric diseases. Biomolecules 10(1):12CrossRef

McVey Neufeld KA, Kay S, Bienenstock J (2018) Mouse strain affects behavioral and neuroendocrine stress responses following administration of probiotic Lactobacillus rhamnosus JB-1 or traditional antidepressant fluoxetine. Front Neurosci 8(12):294CrossRef

Messaoudi M, Lalonde R, Violle N, Javelot H, Desor D, Nejdi A, Bisson JF, Rougeot C, Pichelin M, Cazaubiel M, Cazaubiel JM (2011) Assessment of psychotropic-like properties of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects. Br J Nutr 105(5):755–764PubMedCrossRef

Misra S, Mohanty D (2019) Psychobiotics: a new approach for treating mental illness? Crit Rev Food Sci Nutr 59(8):1230–1236PubMedCrossRef

Miyaoka T, Kanayama M, Wake R, Hashioka S, Hayashida M, Nagahama M, Okazaki S, Yamashita S, Miura S, Miki H, Matsuda H (2018) Clostridium butyricum MIYAIRI 588 as adjunctive therapy for treatment-resistant major depressive disorder: a prospective open-label trial. Clin Neuropharmacol 41(5):151–155

Nguyen TT, Kosciolek T, Eyler LT, Knight R, Jeste DV (2018) Overview and systematic review of studies of microbiome in schizophrenia and bipolar disorder. J Psychiatr Res 99:50–61PubMedPubMedCentralCrossRef

Novik G, Savich V (2020) Beneficial microbiota, probiotics and pharmaceutical products in functional nutrition and medicine. Microbes Infect 22(1):8–18PubMedCrossRef

Ogawa N, Ito M, Yamaguchi H, Shiuchi T, Okamoto S, Wakitani K, Minokoshi Y, Nakazato M (2012) Intestinal fatty acid infusion modulates food preference as well as calorie intake via the vagal nerve and midbrain-hypothalamic neural pathways in rats. Metabolism 61(9):1312–1320PubMedCrossRef

Oleskin AV, Zhilenkova OG, Shenderov BA, Amerhanova AM, Kudrin VS, Klodt PM (2014) Lactic-acid bacteria supplement fermented dairy products with human behavior-modifying neuroactive compounds. J Pharm Nutr Sci 4:199–206CrossRef

Owada Y (2008) Fatty acid binding protein: localization and functional significance in the brain. Tohoku J Exp Med 214(3):213–220PubMedCrossRef

Pompei A, Cordisco L, Amaretti A, Zanoni S, Matteuzzi D, Rossi M (2007) Folate production by bifidobacteria as a potential probiotic property. Appl Environ Microbiol 73(1):179–185PubMedCrossRef

Rasheed N, Alghasham A (2012) Central dopaminergic system and its implications in stress-mediated neurological disorders and gastric ulcers: short review. Adv Pharmacol Sci 2012:1–11

Réus GZ, Jansen K, Titus S, Carvalho AF, Gabbay V, Quevedo J (2015) Kynurenine pathway dysfunction in the pathophysiology and treatment of depression: evidences from animal and human studies. J Psychiatr Res 68:316–328PubMedPubMedCentralCrossRef

Roy CC, Kien CL, Bouthillier L, Levy E (2006) Short-chain fatty acids: ready for prime time? Nutr Clin Pract 21(4):351–366PubMedCrossRef

Saduakhasova S, Kushugulova A, Kozhakhmetov S, Shakhabayeva G, Tynybayeva I, Nurgozhin T, Zhumadilov Z (2013) Antioxidant activity of the probiotic consortium in vitro. Centr Asian J Glob Health 2:115

Sarkar A, Lehto SM, Harty S, Dinan TG, Cryan JF, Burnet PWJ (2016) Psychobiotics and the manipulation of bacteria-gut-brain signals. Trends Neurosci 39:763–781PubMedPubMedCentralCrossRef

Savignac HM, Kiely B, Dinan TG, Cryan JF (2014) Bifidobacteria exert strain-specific effects on stress-related behavior and physiology in BALB/c mice. Neurogastroenterol Motil 26(11):1615–1627

Selhub EM, Logan AC, Bested AC (2014) Fermented foods, microbiota, and mental health: ancient practice meets nutritional psychiatry. J Physiol Anthropol 33(1):1–12CrossRef

Smith SM, Vale WW (2006) The role of the hypothalamic-pituitary-adrenal axis in neuroendocrine responses to stress. Dialogues Clin Neurosci 8(4):383–395PubMedPubMedCentralCrossRef

Soderholm JD, Perdue MH II (2001) Stress and intestinal barrier function. Am J Physiol Gastrointest Liv Physiol 280(1):G7–G13CrossRef

Sudo N, Chida Y, Aiba Y, Sonoda J, Oyama N, Yu XN et al (2004) Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice. J Physiol 558:263–275PubMedPubMedCentralCrossRef

Sullivan RM, Dufresne MM (2006) Mesocortical dopamine and HPA axis regulation: role of laterality and early environment. Brain Res 1076(1):49–59PubMedCrossRef

Sun J, Wang F, Hu X, Yang C, Xu H, Yao Y, Liu J (2018) Clostridium butyricum attenuates chronic unpredictable mild stress-induced depressive-like behavior in mice via the gut-brain axis. J Agric Food Chem 66(31):8415–8421

Tache Y, Bonaz B (2007) Corticotropin-releasing factor receptors and stress-related alterations of gut motor function. J Clin Invest 117(1):33–40PubMedPubMedCentralCrossRef

Taverniti V, Guglielmetti S (2011) The immunomodulatory properties of probiotic microorganisms beyond their viability (ghost probiotics: proposal of paraprobiotic concept). Genes Nutr 6(3):261–274PubMedPubMedCentralCrossRef

Thomas CM, Hong T, Van Pijkeren JP, Hemarajata P, Trinh DV, Hu W, Britton RA, Kalkum M, Versalovic J (2012) Histamine derived from probiotic Lactobacillus reuteri suppresses TNF via modulation of PKA and ERK signaling. PLoS One 7(2):e31951PubMedPubMedCentralCrossRef

Tian P, Wang G, Zhao J, Zhang H, Chen W (2019) Bifidobacterium with the role of 5-hydroxytryptophan synthesis regulation alleviates the symptom of depression and related microbiota dysbiosis. J Nutr Biochem 66:43–51

Tsilingiri K, Rescigno M (2013) Postbiotics: what else? Benefic Microbes 4(1):101–107CrossRef

Wei CL, Wang S, Yen JT, Cheng YF, Liao CL, Hsu CC, Wu CC, Tsai YC (2019) Antidepressant-like activities of live and heat-killed Lactobacillus paracasei PS23 in chronic corticosterone-treated mice and possible mechanisms. Brain Res 1711:202–213PubMedCrossRef

Titel: Therapeutic Mechanisms of Gut Microbiota and Probiotics in the Management of Mental Disorders
verfasst von: Monu Yadav
Anil Kumar
Amarjeet Shandil
Verlag: Springer Nature Singapore
Buch: Probiotic Research in Therapeutics
Print ISBN: 978-981-16-6759-6

Electronic ISBN: 978-981-16-6760-2

Copyright-Jahr: 2022
DOI: https://doi.org/10.1007/978-981-16-6760-2_3

Springer Professional

Abstract

Bitte loggen Sie sich ein, um Zugang zu Ihrer Lizenz zu erhalten.

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Springer Professional "Technik"

Springer Professional "Wirtschaft"

Premium Partner