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Journal of Polymer Research

Erschienen in:

01.03.2021 | ORIGINAL PAPER

Thermal-responsive magnetic hydrogels based on Tragacanth gum for delivery of anticancer drugs

Erschienen in: Journal of Polymer Research | Ausgabe 3/2021

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Abstract

Thermal-responsive magnetic hydrogels (Hydrogel 1 and Hydrogel 2) were synthesized through the copolymerization of maleic anhydride-functionalized Tragacanth gum macromonomer (MATGM), N-isopropylacrylamide (NIPAAm) monomer, and 3-(trimethoxysilyl) propylmethacrylate-modifed magnetic nanoparticles (MPS-MNPs) in the presence of N,N´-methylene-bis(acrylamide) (MBAm) and N,N,N´,N´-tetramethylethylenediamine (TEMED) as crosslinker and accelerator, respectively, using a free radical polymerization approach. The scanning electron microscopy (SEM) images were revealed that the fabricated hydrogels had porous microstructure without microphase separation. The synthesized magnetic hydrogels were loaded with methotrexate (MTX) as an anticancer drug, and their drug loading and encapsulation efficiencies as well as thermal-triggered drug release behaviors were investigated. The biocompatibilities of the fabricated hydrogels were confirmed using MMT assay. The MTX loaded hydrogels were exhibited better anticancer performance than those of the free MTX. Since the biological as well as physicochemical results, the fabricated magnetic hydrogels have high potential for cancer chemotherapy.

Vorheriger Artikel Dual-curable anticorrosion coatings based on epoxymethacrylate/reduced graphene oxide composites

Nächster Artikel The effect of microspheres surface morphology on the enhanced microwave absorbing properties of MWCNTs

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Titel: Thermal-responsive magnetic hydrogels based on Tragacanth gum for delivery of anticancer drugs
Publikationsdatum: 01.03.2021
Erschienen in: Journal of Polymer Research / Ausgabe 3/2021
Print ISSN: 1022-9760
Elektronische ISSN: 1572-8935
DOI: https://doi.org/10.1007/s10965-020-02355-3

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