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Journal of Materials Science

Erschienen in:

02.01.2019 | Materials for life sciences

TiN nanoparticles: synthesis and application as near-infrared photothermal agents for cancer therapy

verfasst von: Wenqi Jiang, Qingge Fu, Hengyong Wei, Aihua Yao

Erschienen in: Journal of Materials Science | Ausgabe 7/2019

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Abstract

We have developed TiN nanoparticles (NPs) as a novel near-infrared-activated photothermal agent. The effect of nitridation temperature on the optical property and photothermal performance of the TiN NPs were investigated. The nanoparticles nitrided at 1000 °C presented a significant absorption along the whole biological spectral range (i.e., for wavelengths above 700 nm). After coated with polystyrene sulfonate (PSS) and poly(diallyldimethylammonium chloride) (PDDA), they exhibited well-defined spherical morphology with average size of ~ 50 nm. We also demonstrated their therapeutic efficacy against SW1990 pancreatic cancer cells. The results indicated that the PSS/PDDA-coated TiN NPs offered several advantages including high photothermal conversion efficiency (44.6%), high photothermal stability, broad spectral tunability, low cytotoxicity and facile synthesis process. These features make TiN NPs promising alternative for use as a photothermal agent in cancer photothermal treatment.

Vorheriger Artikel Facile synthesis of exfoliated graphitic carbon nitride for photocatalytic degradation of ciprofloxacin under solar irradiation

Nächster Artikel Effect of 0.4 wt% yttrium addition and heat treatment on the high-temperature compression behavior of cast AZ80

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Titel: TiN nanoparticles: synthesis and application as near-infrared photothermal agents for cancer therapy
verfasst von: Wenqi Jiang
Qingge Fu
Hengyong Wei
Aihua Yao
Publikationsdatum: 02.01.2019
Verlag: Springer US
Erschienen in: Journal of Materials Science / Ausgabe 7/2019
Print ISSN: 0022-2461
Elektronische ISSN: 1573-4803
DOI: https://doi.org/10.1007/s10853-018-03272-z

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