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01.02.2014 | Original Paper

Topical caffeine delivery using biocellulose membranes: a potential innovative system for cellulite treatment

verfasst von: Nuno H. C. S. Silva, Inês Drumond, Isabel F. Almeida, Paulo Costa, Catarina F. Rosado, Carlos Pascoal Neto, Carmen S. R. Freire, Armando J. D. Silvestre

Erschienen in: Cellulose | Ausgabe 1/2014

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Abstract

In this study, biocellulose (BC) membranes have been investigated as caffeine topical delivery systems, for the potential treatment of cellulite. BC-caffeine membranes were prepared by a simple approach and the permeation of caffeine through human epidermis, from BC or from conventional formulation systems (solution and gel), was compared in vitro to assess their therapeutic applicability. Diffusion studies with Franz cells showed that the incorporation of caffeine in BC membranes provided lower permeation rates than those obtained with the conventional formulations. These results combined with the possibility of producing BC membranes with different shapes demonstrate that these materials are promising biosystems for topical delivery of caffeine, showing reproducibility and an extended and predictable caffeine release over time, leading to their potential use for cellulite attenuation.

Vorheriger Artikel Characterization of sugarcane bagasse by autofluorescence microscopy

Nächster Artikel Rheological behavior of cellulose/silk fibroin blend solutions with ionic liquid as solvent

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Akhter SA, Barry BW (1985) Absorption through human skin of ibuprofen and flurbiprofen; effect of dose variation, deposited drug films, occlusion and penetration enhancer N-methyl-2-pyrrolidone. J Pharm Pharmacol 37(1):27–37CrossRef

Almeida IF, Pereira T, Silva NHCS, Gomes FP, Silvestre AJD, Freire CSR, Costa PC (2013) Bacterial cellulose membranes as drug delivery systems: an in vivo skin compatibility study. Eur J Pharm Biopharm. doi:10.1016/j.ejpb.2013.08.008

Andrade FK, Silva JP, Carvalho M, Castanheira EMS, Soares R, Gama M (2011) Studies on the hemocompatibility of bacterial cellulose. J Biomed Mater Res A 98A(4):554–566CrossRef

A-sasutjarit R, Sirivat A, Vayumhasuwan P (2005) Viscoelastic properties of Carbopol 940 gels and their relationships to piroxicam diffusion coefficients in gel bases. Pharm Res 22(12):2134–2140CrossRef

Avram MM (2004) Cellulite: a review of its physiology and treatment. J Cosmet Laser Ther 6(4):181–185CrossRef

Bodhibukkana C, Srichana T, Kaewnopparat S, Tangthong N, Bouking P, Martin GP, Suedee R (2006) Composite membrane of bacterially-derived cellulose and molecularly imprinted polymer for use as a transdermal enantioselective controlled-release system of racemic propranolol. J Control Release 113(1):43–56CrossRef

Boonme P, Amnuaikit T, Chusuit T, Raknam P (2011) Effects of a cellulose mask synthesized by a bacterium on facial skin characteristics and user satisfaction. Med Device Evid Res 4(1):77–81CrossRef

Budhiono A, Rosidi B, Taher H, Iguchi M (1999) Kinetic aspects of bacterial cellulose formation in nata-de-coco culture system. Carbohydr Polym 40(2):137–143CrossRef

Czaja W, Krystynowicz A, Bielecki S, Brown RM Jr (2006a) Microbial cellulose—the natural power to heal wounds. Biomaterials 27(2):145–151CrossRef

Czaja W, Young D, Kawecki M, Brown RM (2006b) The future prospects of microbial cellulose in biomedical applications. Biomacromolecules 8(1):1–12CrossRef

Czaja W, Krystynowicz A, Kawecki M, Wysota K, Sakiel S, Wróblewski P, Glik J, Nowak M, Bielecki S (2007) Biomedical applications of microbial cellulose in burn wound recovery. In: Brown RM, Saxena IM (eds) Cellulose: molecular and structural biology. Springer, Netherlands, pp 307–321CrossRef

Diezsales O, Copovi A, Casabo VG, Herraez M (1991) A modelistic approach showing the importance of the aqueous layers in in vitro diffusion studies and in vitro–in vivo correlations. Int J Pharm 77(1):1–11CrossRef

Fontana JD, de Souza AM, Fontana CK, Torriani IL, Moreschi JC, Gallotti BJ, de Souza SJ, Narcisco GP, Bichara JA, Farah LFX (1990) Acetobacter cellulose pellicle as a temporary skin substitute. Appl Biochem Biotechnol 24–25(4):253–264CrossRef

Garnier Bodytonic (2013) http://www.garnier.pt/_pt/_pt/our_products/product.aspx?tpcode=OUR_PRODUCTS^PRD_BODYCARE^ANTI_CELLULITE^ANTI_CELLULITE_DISCOVER^ANTI_CELLULITE_RTN3&prdcode=P21024. Retrieved 30 May 2013

Helenius G, Bäckdahl H, Bodin A, Nannmark U, Gatenholm P, Risberg B (2006) In vivo biocompatibility of bacterial cellulose. J Biomed Mater Res A 76A(2):431–438CrossRef

Hestrin S, Schramm M (1954) Synthesis of cellulose by Acetobacter xylinum. II. Preparation of freeze-dried cells capable of polymerizing glucose to cellulose. Biochem J 58(2):345–352

Hirai A, Tsuji M, Horii F (2002) TEM study of band-like cellulose assemblies produced by Acetobacter xylinum at 4 °C. Cellulose 9(2):105–113CrossRef

Hu Y, Catchmark JM (2010) Formation and characterization of spherelike bacterial cellulose particles produced by Acetobacter xylinum JCM 9730 strain. Biomacromolecules 11(7):1727–1734CrossRef

Hu Y, Catchmark JM (2011) In vitro biodegradability and mechanical properties of bioabsorbable bacterial cellulose incorporating cellulases. Acta Biomater 7(7):2835–2845CrossRef

Kamel S, Ali N, Jahangir K, Shah SM, El-Gendy AA (2008) Pharmaceutical significance of cellulose: a review. Express Polym Lett 2(11):758–778CrossRef

Klemm D, Schumann D, Udhardt U, Marsch S (2001) Bacterial synthesized cellulose—artificial blood vessels for microsurgery. Prog Polym Sci 26(9):1561–1603CrossRef

Klemm D, Schumann D, Kramer F, Heßler N, Hornung M, Schmauder H-P, Marsch S (2006) Nanocelluloses as innovative polymers in research and application. Adv Polym Sci 2005:49–96CrossRef

Kligman AM, Christophel E (1963) Preparation of isolated sheets of human stratum corneum. Arch Dermatol 88(6):702–705CrossRef

Lupi O, Semenovitch IJ, Treu C, Bottino D, Bouskela E (2007) Evaluation of the effects of caffeine in the microcirculation and edema on thighs and buttocks using the orthogonal polarization spectral imaging and clinical parameters. J Cosmet Dermatol 6(2):102–107CrossRef

Martínez H, Brackmann C, Enejder A, Gatenholm P (2012) Mechanical stimulation of fibroblasts in micro-channeled bacterial cellulose scaffolds enhances production of oriented collagen fibers. J Biomed Mater Res A 100A(4):948–957CrossRef

Mayall RC, Mayall ACDC, Mayall LCDG, Rocha HC, Marques LCB (1990) Tratamento das úlceras tróficas dos membros com um novo substituto da pele. Rev Bras Cir 4:257–283

Meftahi A, Khajavi R, Rashidi A, Sattari M, Yazdanshenas M, Torabi M (2010) The effects of cotton gauze coating with microbial cellulose. Cellulose 17(1):199–204CrossRef

Nair L, Laurencin C (2006) Polymers as biomaterials for tissue engineering and controlled drug delivery. In: Lee K, Kaplan D (eds) Advances in biochemical engineering/biotechnology. Springer, Berlin, pp 47–90

Peltonen L, Solberg VM (1984) A comparison of 0.1 % hydrocortisone cream (milliderm 0.1 %;AL) and 1 % hydrocortisone cream (hydrocortisone cream 1 % orion) in patients with non-infected eczemas. Curr Ther Res Clin Exp 35:78–82

Pires-de-Campos MSM, Leonardi GR, Chorilli M, Spadari-Bratfisch RC, Polacow MLO, Grassi-Kassisse DM (2008) The effect of topical caffeine on the morphology of swine hypodermis as measured by ultrasound. J Cosmet Dermatol 7(3):232–237CrossRef

Rawlings AV, Harding CR, Watkinson A, Chandar P, Scott IR (2002) Humectants. Skin Moisturization 25:245–266

Rinaudo M (2008) Main properties and current applications of some polysaccharides as biomaterials. Polym Int 57(3):397–430CrossRef

Sanchavanakit N, Sangrungraungroj W, Kaomongkolgit R, Banaprasert T, Pavasant P, Phisalaphong M (2006) Growth of human keratinocytes and fibroblasts on bacterial cellulose film. Biotechnol Prog 22(4):1194–1199CrossRef

Shoda M, Sugano Y (2005) Recent advances in bacterial cellulose production. Biotechnol Bioprocess Eng 10(1):1–8CrossRef

Siddons S (2013) Cellulite causes and treatments. Discov Fit Health. http://health.howstuffworks.com/skin-care/problems/beauty/cellulite2015.htm. Retrieved on July 22, 2013

Siqueira G, Bras J, Dufresne A (2010) Cellulosic bionanocomposites: a review of preparation, properties and applications. Polymers 2(4):728–765CrossRef

Trovatti E, Serafim LS, Freire CSR, Silvestre AJD, Neto CP (2011a) Gluconacetobacter sacchari: an efficient bacterial cellulose cell-factory. Carbohydr Polym 86(3):1417–1420CrossRef

Trovatti E, Silva NHCS, Duarte IF, Rosado CF, Almeida IF, Costa P, Freire CSR, Silvestre AJD, Neto CP (2011b) Biocellulose membranes as supports for dermal release of lidocaine. Biomacromolecules 12(11):4162–4168CrossRef

Trovatti E, Freire CSR, Pinto PC, Almeida IF, Costa P, Silvestre AJD, Neto CP, Rosado C (2012) Bacterial cellulose membranes applied in topical and transdermal delivery of lidocaine hydrochloride and ibuprofen: in vitro diffusion studies. Int J Pharm 435(1):83–87CrossRef

Velasco MVR, Tano CTN, Machado-Santelli GM, Consigleri VO, Kaneko TM, Baby AP (2008) Effects of caffeine and siloxanetriol alginate caffeine, as anticellulite agents, on fatty tissue: histological evaluation. J Cosmet Dermatol 7(1):23–29CrossRef

Wang J, Zhu Y, Du J (2011) Bacterial cellulose: a natural nanomaterial for biomedical applications. J Mech Med Biol 11(2):285–306CrossRef

Wiegand C, Hipler U-C (2010) Polymer-based biomaterials as dressings for chronic stagnating wounds. Macromol Symp 294(2):1–13CrossRef

Yang C, Gao C, Wan Y, Tang T, Zhang S, Dai K (2011) Preparation and characterization of three-dimensional nanostructured macroporous bacterial cellulose/agarose scaffold for tissue engineering. J Porous Mater 18(5):545–552CrossRef

Titel: Topical caffeine delivery using biocellulose membranes: a potential innovative system for cellulite treatment
verfasst von: Nuno H. C. S. Silva
Inês Drumond
Isabel F. Almeida
Paulo Costa
Catarina F. Rosado
Carlos Pascoal Neto
Carmen S. R. Freire
Armando J. D. Silvestre
Publikationsdatum: 01.02.2014
Verlag: Springer Netherlands
Erschienen in: Cellulose / Ausgabe 1/2014
Print ISSN: 0969-0239
Elektronische ISSN: 1572-882X
DOI: https://doi.org/10.1007/s10570-013-0114-1

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