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01.06.2021 | Research paper

Traceable metallic antigen release for enhanced cancer immunotherapy

verfasst von: Fangfang Lv, Yan Jin, Xiaochen Feng, Miao Fan, Cui Ren, Xinyue Dai, Jinchao Zhang, Zhenhua Li, Yi Jin, Huifang Liu

Erschienen in: Journal of Nanoparticle Research | Ausgabe 6/2021

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Abstract

Tumor vaccine has shown outstanding advantages and good therapeutic effects in tumor immunotherapy. However, antigens in tumor vaccines can be easily cleared by the reticuloendothelium system in advance, which leads to poor therapeutic effect of tumor vaccines. Moreover, it was still hard to monitor the fate and distribution of antigens. To address these limitations, we synthesized a traceable nanovaccine based on gold nanocluster-labeled antigens and upconversion nanoparticles (UCNPs) for the treatment of melanoma in this study. PH-sensitive Schiff base bond is introduced between UCNPs and gold nanocluster-labeled ovalbumin antigens for monitoring antigens release. Our studies demonstrated that UCNPs conjugated metallic antigen showed excellent biocompatibility, pH-sensitive and therapeutic effect.

Vorheriger Artikel Supramolecular poly(vinyl alcohol)-folate structure as functional layer and colloidal stabilizer of poly(vinyl acetate) nanoparticles with potential use as nanocarrier for hydrophobic antitumor agents

Nächster Artikel Dynamic magnetic properties of Ni2FeGa Heusler alloy nanoparticles

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Titel: Traceable metallic antigen release for enhanced cancer immunotherapy
verfasst von: Fangfang Lv
Yan Jin
Xiaochen Feng
Miao Fan
Cui Ren
Xinyue Dai
Jinchao Zhang
Zhenhua Li
Yi Jin
Huifang Liu
Publikationsdatum: 01.06.2021
Verlag: Springer Netherlands
Erschienen in: Journal of Nanoparticle Research / Ausgabe 6/2021
Print ISSN: 1388-0764
Elektronische ISSN: 1572-896X
DOI: https://doi.org/10.1007/s11051-021-05256-8

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