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Erschienen in:
An In-Silico Structural Analysis of the Interactions of SoxY and SoxZ from Moderately Thermophilic Betaproteobacterium, Hydrogenophilus thermoluteolus in the Global Sulfur Oxidation Cycle Kapitel lesen Erstes Kapitel lesen

2015 | OriginalPaper | Buchkapitel

Understanding the Interaction of Human Formin Binding Protein 4 with Formin FMN1

verfasst von : Amit Das, Simanti Bhattacharya, Angshuman Bagchi, Rakhi Dasgupta

Erschienen in: Information Systems Design and Intelligent Applications

Verlag: Springer India

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Abstract

The proline rich formin homolog 1 (FH1) region of mouse formin FMN1 was initially reported to bind to WW domains and mediate its interaction with formin binding protein 4 (FNBP4) via the WW domain of FNBP4. However further structural, biochemical and functional details about this interaction have never been reported. The nature of the study that first reported this interaction, along with lack of further information, later created doubt about the possibility of this interaction under cellular environment. In this context, this computational study confirms the binding of mouse formin FMN1 FH1 with the 1st WW domain of FNBP4. Combined with our previous reports, this study concludes that only the 1st WW domain of FNBP4 is able to mediate its interaction with formins FH1 regions and its binding is stronger to the PPXXPP motif compared to the PPXP or PPXPP motifs, all of which are found in formin FH1 region.

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Vorheriges Kapitel HHT Based Features for Discrimination of EMG Signals
Nächstes Kapitel In-Silico Structural Analysis of SoxF Protein Through Molecular Modelling and Protein-Protein Docking from Hydrogenophilus thermoluteolus: An Approach to Understand the Molecular Mechanism of Thiosulfate Oxidation
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Metadaten
Titel
Understanding the Interaction of Human Formin Binding Protein 4 with Formin FMN1
verfasst von
Amit Das
Simanti Bhattacharya
Angshuman Bagchi
Rakhi Dasgupta
Copyright-Jahr
2015
Verlag
Springer India
Buch
Information Systems Design and Intelligent Applications

Print ISBN: 978-81-322-2246-0

Electronic ISBN: 978-81-322-2247-7

Copyright-Jahr: 2015

DOI
https://doi.org/10.1007/978-81-322-2247-7_12

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