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Erschienen in:
2006 | OriginalPaper | Buchkapitel
UnitExpressions: A Rational Normalization Scheme for DNA Microarray Data
verfasst von : Alfred Ultsch
Erschienen in: From Data and Information Analysis to Knowledge Engineering
Verlag: Springer Berlin Heidelberg
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A new normalization scheme for DNA microarray data, called UnitExpresion, is introduced. The central idea is to derive a precise model of unexpressed genes. Most of the expression rates in a typical microarray experiment belong to this category. Pareto probability density estimation (PDE) and EM are used to calculate a precise model of this distribution. UnitExpressions represent a lower bound on the probability that a gene on a microarray is expressed. With UnitExpressions experiments from different microrarrays can be compared even across different studies. UnitExpressions are compared to standardized LogRatios for distance calculation in hierarchical clustering.